ID A0A1I8MMD5_MUSDO Unreviewed; 1586 AA.
AC A0A1I8MMD5;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Platelet-derived growth factor receptor beta isoform X2 {ECO:0000313|RefSeq:XP_011290905.1};
GN Name=101895886 {ECO:0000313|EnsemblMetazoa:MDOA006478-PG};
GN Synonyms=LOC101895886 {ECO:0000313|RefSeq:XP_011290905.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA006478-PG};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA006478-PG}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA006478-PG};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_011290905.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_011290905.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
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DR RefSeq; XP_011290905.1; XM_011292603.2.
DR EnsemblMetazoa; MDOA006478-RG; MDOA006478-PG; MDOA006478.
DR VEuPathDB; VectorBase:MDOA006478; -.
DR OrthoDB; 1614410at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProt.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0022008; P:neurogenesis; IEA:UniProt.
DR CDD; cd00096; Ig; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 6.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR PANTHER; PTHR24416:SF600; PDGF-AND VEGF-RECEPTOR RELATED, ISOFORM J; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 2.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PIRSF; PIRSF000615; TyrPK_CSF1-R; 4.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 5.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Magnesium {ECO:0000256|PIRSR:PIRSR000615-3};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR000615-3};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_011290905.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 864..886
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 348..446
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 664..760
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 769..857
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 940..1361
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 311..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1103..1125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1414..1485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1519..1586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1440..1474
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1551..1577
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1209
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000615-1"
FT BINDING 974
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
FT BINDING 1214
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR000615-3"
FT BINDING 1227
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR000615-3"
SQ SEQUENCE 1586 AA; 178888 MW; 1F691BE6887ED899 CRC64;
MNLIRPLRPS RSRRGSSNLH KMDLRFLLLL GLWISNSIIG CAAMPHPKPQ DASNRISKSN
DMDYERNYAV ELGAPLLIPL QDEVILEANT DFVLRCESNE DIVWKHPFES DVEESTYQPD
DPSRPFGRIL TLKMVSYSSV GSYYCIKESS VNVTHLLSIE DATLTDLANN NLASSIYVFV
NDTTNLLAPM PFPVIHVVQF EDAVIPCKPS MPDVDVLLTM PNGKTLASDS GVRYNPQLGF
VIEVRSMEEH GDYICRPKIP SPDNEAESTS VETILALQLD NGSITTTQSS TGIMGLTNSK
QLDINTITNF DTTPTTSPIP NSSTITSTLT TRPATNTVPT RTEKMERPTV TSTSKHHALV
GETFQLVCEI RTAHDVVVKI TWNMPEGVDP ERVTQVSRPT NKYTVHHTYT ESILTIRNAQ
LSDTGKYTCD VMDHSKHKNK DSYDMVIMEE GQSYIDMHEQ NNYYEIASTA NKTMQMVVLY
KGYPHPTLQW FRPDGTEIPQ GVSFNGKYNV TTLDHKSTLY IKNASLLDSG VYVVRAANGN
VRKEREFTVT VHDSPMVAID DVYVHEGEKA HVQCRVKSHV KAIVTWVFQP CSIEPRWPSC
DKKLIQDFNE TSSRNGDTFI DFVYDMYFVP PSPGIVYCTA ANAIDKVVHR GNAKAHVLVR
DIEENMTIYG INDTDIIARG DEVTITCAAV AYYFSDNIQW FDSKREPIKE SNDIKINRSK
SNYSYKSSLT FKKIKDEDQG IYECGAAHIN DSKIEYRIIN LIAHEPSSPQ MTYTNLGNNI
KLERKLGESL ELRCESHAIP KATVTWYKDD VELVNISSEY VGHMVIPYLK PDDQGQYKCV
VANRLGVVEQ TVNVKITNIP GLTLGWICGI VLLLLILIGL VIYLYIRVKR ERKLLRELKA
AGLANFEEGA LEHINPALTL DEQADLLPYD RCFEFPRDKL KLGKQLGAGA FGVVLKAHAE
GIRPEEKETV VAVKMVKRNA NNEVMRALVS ELKIMVHLGQ HLNVVNLLGA VTKNIAKREL
MVIVEFCRYG NVQNFLMRNR KRFINQINPH TGKIDANITT QRFSDNFELD RSGLKYVNLS
FSNHQYINHV NNMNNMNNYY SINNRRETDN DPRSGTRAGR PGSTGYISKS ELYEGQINTC
GTENTVMTTV PEDEDNIMSN NSVQPAWRSN YKSDSTEAMS ITTMDLISWS YQVACGMEYL
SSKKVLHGDL AARNILLCED NIIKICDFGL ARSMYKSDNY KKQGDAPLPI KWLALESLSD
HIFSTYTDVW SFGIVLWELF SLAKVPYPEI DANQSLYLKL KDGYRMDKPP YANDDLYEIM
LECWRTNPES RPLFNVLKER FGQMLGEEVA SHYMDLNEPY LRVNTEYMKR NQTDYLALMG
SPDEMAPPPP RYVNGHILPE IRIDLSSDDY LQMSPNGGSV IFSPTRPKDS PPICTEDNAD
HPPTISTTSF NFPDNAAEQH SPTLANNLDS PNNSKPPRVK KDGIDPLPEE IPMLDAVNHH
EDSPDQPRKY AQMLQQQTKN MPTPSPRHHI KETKLNGGGG GEDAENYINL KSPKKTINNN
GAKHPEAFSN PSYQILKPGT DNIDVK
//
