ID A0A1I8MMH0_MUSDO Unreviewed; 907 AA.
AC A0A1I8MMH0;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Survival of motor neuron-related-splicing factor 30 {ECO:0000256|ARBA:ARBA00041083};
DE AltName: Full=Survival motor neuron domain-containing protein 1 {ECO:0000256|ARBA:ARBA00042567};
DE AltName: Full=Tudor domain-containing protein 3 {ECO:0000256|ARBA:ARBA00013421};
GN Name=101901400 {ECO:0000313|EnsemblMetazoa:MDOA006503-PA};
GN Synonyms=LOC101901400 {ECO:0000313|RefSeq:XP_005177150.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA006503-PA};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA006503-PA}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA006503-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005177150.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_005177150.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in spliceosome assembly.
CC {ECO:0000256|ARBA:ARBA00037618}.
CC -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
CC -!- SIMILARITY: Belongs to the SMN family. {ECO:0000256|ARBA:ARBA00005371}.
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DR RefSeq; XP_005177150.1; XM_005177093.3.
DR STRING; 7370.A0A1I8MMH0; -.
DR EnsemblMetazoa; MDOA006503-RA; MDOA006503-PA; MDOA006503.
DR GeneID; 101901400; -.
DR KEGG; mde:101901400; -.
DR VEuPathDB; VectorBase:MDOA006503; -.
DR eggNOG; KOG3683; Eukaryota.
DR OrthoDB; 228723at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR CDD; cd14297; UBA2_spUBP14_like; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 2.40.50.770; RecQ-mediated genome instability protein Rmi1, C-terminal domain; 1.
DR InterPro; IPR042470; RMI1_N_C_sf.
DR InterPro; IPR013894; RMI1_OB.
DR InterPro; IPR010304; SMN_Tudor.
DR InterPro; IPR002999; Tudor.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR13681:SF26; SURVIVAL OF MOTOR NEURON-RELATED-SPLICING FACTOR 30; 1.
DR PANTHER; PTHR13681; SURVIVAL OF MOTOR NEURON-RELATED-SPLICING FACTOR 30-RELATED; 1.
DR Pfam; PF08585; RMI1_N_C; 1.
DR Pfam; PF06003; SMN_Tudor; 1.
DR Pfam; PF00627; UBA; 1.
DR SMART; SM01161; DUF1767; 1.
DR SMART; SM00333; TUDOR; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS50304; TUDOR; 1.
DR PROSITE; PS50030; UBA; 1.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW Spliceosome {ECO:0000256|ARBA:ARBA00022728}.
FT DOMAIN 249..288
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT DOMAIN 786..844
FT /note="Tudor"
FT /evidence="ECO:0000259|PROSITE:PS50304"
FT REGION 200..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 286..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 341..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 401..644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 659..683
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 715..738
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 880..907
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..221
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..363
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..416
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..499
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 500..520
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 521..538
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 547..644
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 715..736
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 907 AA; 99091 MW; 19BCBBA62B31322C CRC64;
MTLLQKLKDQ GWYLTQEGLK KLTTDVQTED VQKIIKAALD WDLKEIGGGA IPTKPESNGN
IPGRIVLQMQ KMRNISAPKA NEESTAAPRF LQLELTDGTN SILALELERI PNLNLKIPPG
TKLYFKAEKL QLMQGLLVLK EAEVQILGGN VEHMVEKWEI ARQMQKYARS NRRLSGSGGP
PPWIDFGKRL DAHRDALPQD RNFKSLQAAN EKDKNSKEND EFTASRTQAI AEAAKAGQKK
VFGGGQQNIL DHNVKKILEK GYSEEDAKYA LKATNNNLER ALYNLKRRNK GATESTTKAA
TTTVGNQRGR GSAKDEIAPA SKPQTNVSLF DFLTDKLPAT VTTEAPPPQA ASNSSQNNRN
PKELNKGKSN DSNAKPQSNT SGNKFENNMS SSFAANRIKP EEKFTPSQNQ QSQRSNYNQR
DERRSNPPNK QGNRGNERGG RSNVQNNERT SNSQSAPSNE MKAPPPSNNV NSSTSTSNGN
GNTNNNNNAS QNTNYRTNSS RRNDRNERPP APRKDQRDQT ARPTGNSGGN YQGNRRSQEY
RTNDSRPYQQ RDNNNRNTSE SKSASNYQSN QQNQPPKTSN ADVDKLVEST AKLTIQNKKE
TSYNSSQNRG GRHQYASTRS TNVSSNSSQS KSGGGNQGQQ GGAQFIGSLN FTNKITQNSS
PQVAANQQHQ PQPQPSYVSQ LPNGFAYDPS KIMGFQSKEA NEYAMNLLKS QGLLPQQSPV
AGPQAAAQAT QVPPPTQPQL LANPQAAPAV TYMTPSPNSG FVAAPPPPQQ GPIPQYGMLP
QGGGWNWNVG DLCLAKYWED GNYYDAKITA VSENTCVVFF LGYGNHEEVV KTDCLPLGDE
SHYPINAFQG GPPPTAVHAP MQQIPATFLA ANSAAGNGGI GGGGGNQRYR GERQMYVPPP
KRGANNN
//
