UniProt: A0A1I8MNT6

Database: UniProt
Entry: A0A1I8MNT6_MUSDO

LinkDB:  A0A1I8MNT6_MUSDO 
Original site:  A0A1I8MNT6_MUSDO

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Ontology (2)   
   GO (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1)   
   NCBI-Gene (1)   
Protein sequence (2)   
   RefSeq(pep) (2)   
Protein domain (3)   
   InterPro (1)   
   Pfam (1)   
   PROSITE (1)   
All databases (9)   

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ID   A0A1I8MNT6_MUSDO        Unreviewed;       398 AA.
AC   A0A1I8MNT6;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   RecName: Full=Palmitoyltransferase {ECO:0000256|RuleBase:RU079119};
DE            EC=2.3.1.225 {ECO:0000256|RuleBase:RU079119};
GN   Name=101892332 {ECO:0000313|EnsemblMetazoa:MDOA006937-PB};
GN   Synonyms=LOC101892332 {ECO:0000313|RefSeq:XP_011292586.1,
GN   ECO:0000313|RefSeq:XP_019892347.1};
OS   Musca domestica (House fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC   Muscidae; Musca.
OX   NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA006937-PB};
RN   [1] {ECO:0000313|EnsemblMetazoa:MDOA006937-PB}
RP   IDENTIFICATION.
RC   STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA006937-PB};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_011292586.1, ECO:0000313|RefSeq:XP_019892347.1}
RP   IDENTIFICATION.
RC   STRAIN=Aabys {ECO:0000313|RefSeq:XP_011292586.1,
RC   ECO:0000313|RefSeq:XP_019892347.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-
CC         hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-
CC         COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151;
CC         EC=2.3.1.225; Evidence={ECO:0000256|RuleBase:RU079119};
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- DOMAIN: The DHHC domain is required for palmitoyltransferase activity.
CC       {ECO:0000256|RuleBase:RU079119}.
CC   -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
CC       {ECO:0000256|RuleBase:RU079119}.
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DR   RefSeq; XP_011292586.1; XM_011294284.2.
DR   RefSeq; XP_019892347.1; XM_020036788.1.
DR   STRING; 7370.A0A1I8MNT6; -.
DR   EnsemblMetazoa; MDOA006937-RB; MDOA006937-PB; MDOA006937.
DR   GeneID; 101892332; -.
DR   VEuPathDB; VectorBase:MDOA006937; -.
DR   eggNOG; KOG1311; Eukaryota.
DR   OrthoDB; 4152777at2759; -.
DR   Proteomes; UP000095301; Unassembled WGS sequence.
DR   Proteomes; UP000694905; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR001594; Palmitoyltrfase_DHHC.
DR   PANTHER; PTHR22883:SF471; PALMITOYLTRANSFERASE ZDHHC23; 1.
DR   PANTHER; PTHR22883; ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN; 1.
DR   Pfam; PF01529; DHHC; 1.
DR   PROSITE; PS50216; DHHC; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW   ECO:0000256|RuleBase:RU079119};
KW   Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW   Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU079119};
KW   Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW   Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU079119};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU079119};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU079119}.
FT   TRANSMEM        115..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   TRANSMEM        141..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   TRANSMEM        167..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   TRANSMEM        298..322
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   TRANSMEM        349..371
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   DOMAIN          245..375
FT                   /note="Palmitoyltransferase DHHC"
FT                   /evidence="ECO:0000259|Pfam:PF01529"
SQ   SEQUENCE   398 AA;  45364 MW;  521635D03EE57593 CRC64;
     MTNYDYIAVA QKAGEEESQI DSSLCCCEYI DRDKQRFHTL GCCCNCVDLD TAFTDCITCN
     KVDASNKRNM LLTFQDRLRL PWRGGAKRIS MEAIIPGAVY PLVLGLAALN EVTSYIMLGS
     IIVFLGYAHQ YIKRNNVKTR FFYMWLWWSV VYMVAGLQFA VPLLELLPEE NCILVLMGCA
     SVYFMWQTKK HAAACHDIPS RSTDDDLADI TEATAAEEEE EAAAHTALLI DNDSPIRSQK
     NRANSHQTNM CHVCRKYVSA RTIHCHVCNA CIMMQSHHSY WLDCCVGQYN LRYYNAGMVF
     SICTLFFGVY LTLTAICHPQ LIGRIWNIPL MMPDDCSEVF DEYTLGTSYV LSLYAIIMIV
     YQLISLILQV IKCTRGPMFF IFGDMSQPFS KFYKKLST
//

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