ID A0A1I8MRB0_MUSDO Unreviewed; 1970 AA.
AC A0A1I8MRB0;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Myosin heavy chain, non-muscle {ECO:0000313|RefSeq:XP_005183384.1};
GN Name=101892851 {ECO:0000313|EnsemblMetazoa:MDOA007664-PB};
GN Synonyms=LOC101892851 {ECO:0000313|RefSeq:XP_005183384.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA007664-PB};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA007664-PB}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA007664-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005183384.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_005183384.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR RefSeq; XP_005183384.1; XM_005183327.3.
DR STRING; 7370.A0A1I8MRB0; -.
DR EnsemblMetazoa; MDOA007664-RB; MDOA007664-PB; MDOA007664.
DR VEuPathDB; VectorBase:MDOA007664; -.
DR eggNOG; KOG0161; Eukaryota.
DR OrthoDB; 2877572at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0030017; C:sarcomere; IEA:UniProt.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd14911; MYSc_Myh2_insects_mollusks; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 2.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.30.70.1590; -; 1.
DR Gene3D; 6.10.250.2420; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 4.10.270.10; Myosin, subunit A; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF71; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR Pfam; PF00612; IQ; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00015; IQ; 1.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000694905}.
FT DOMAIN 32..82
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 86..781
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 659..681
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1038..1057
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1331..1357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1657..1678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1691..1724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1911..1970
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1695..1715
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1930..1944
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 179..186
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1970 AA; 227196 MW; EB7D835E5A52384F CRC64;
MAEEVDRNDP ELKYLSVERN QFNDPATQAE WTQKRLVWVP HENQGFCAAS IKREHGDEVE
VELTETGKRV MVLRDDIQKM NPPKFDKVED MAELTCLNEA SVLHNIKDRY YSGLIYTYSG
LFCVVVNPYK KLPIYTEKIM ERYKGIKRHE VPPHVFAITD TAYRSMLQDR EDQSILCTGE
SGAGKTENTK KVIQYLAYVA ASKPKGSGAG PHPALIIGEL EQQLLQANPI LEAFGNAKTV
KNDNSSRFGK FIRINFDASG YISGANIETY LLEKSRAIRQ AKDERTFHIF YQLLAGASPE
QREKFILDDI KTYPFLSNGN LPVPGVDDFA EYQATVKSMN IMGMTAEDFN SIFRIVSAVL
LFGCMKFRQE RNNDQATLPD NTVAQKIAHL LGLSVTDMTR AFLTPRIKVG RDFVTKAQTK
EQVEFAVEAI SKACYERMFK WLVNRINRSL DRTKRQGASF IGILDMAGFE IFELNSFEQL
CINYTNEKLQ QLFNHTMFIL EQEEYQREGI EWKFIDFGLD LQPTIDLIDK PGGIMALLDE
ECWFPKATDK TFVEKLVSAH SMHPKFMKTD FRGVADFAIV HYAGKVDYSA AKWLMKNMDP
LNENIVSLLQ NSQDPFVVNI WKDAEIVGMA HQALTDTQFG ARTRKGMFRT VSHLYKEQLA
KLMDTLRNTN PNFVRCIIPN HEKRAGKIDA PLVLDQLRCN GVLEGIRICR QGFPNRIPFQ
EFRQRYELLT PNVIPKGFMD GKKACEKMIQ ALELDSNLYR VGQSKIFFRA GVLAHLEEER
DYKITDLIVN FQAFCRGFLA RRNYQKRLQQ LNAIRIIQRN CAAYLKLRNW QWWRLYTKVK
PLLEVTKQEE KLVQKEDELK QVREKLETLA KSTQEYERKY QQALEEKTSL AEQLQAEIEL
CAEAEESRSR LMARKQELED MMQELETRIE EEEERVLALG VEKKKLELNI QDLEEQLEEE
EAARQKLQLE KVQLDGKIKK YEEELALTED QNQKLLKEKK ILEERANDLS QTLAEEEEKA
KHLAKLKTKH EATIAELEER MHKDQQQRQE TDRSKRKIET EMADLKEQLN ERRIQVEELQ
VQLGKREEEL TQTLMRIDEE SAAKAAAQKA QREIESQLAE LQEDLEAEKA ARAKAEKIRR
DLGEELEALK NELLDSLDTT AAQQELRSKR EQELASLKKS LEEETVNHEA SIAEMRHKHV
QELNGINEQL ENLRKAKAVL EKAKSTLEAE NADLATELRS VNSSRQENDR RRKQAESQIA
ELQVKLAEVE RARSELQEKC TKLQQESEYI TNQLEEAELK ASAAVKSAGN MESQLAETQQ
LLEEETRQKL SLSSKLRQLE SEKEALQEQL EEDEETKKNY ERKLAELSAT MQEIKKKAEE
DADAVKELEE GKKRLNKSIE DLERQVKELT AQNDRLDKSK KKIQSELEDA TIELEAQRTK
VLELEKKQKN FDKILAEEKA ISEQYAQERD TAEREAREKE TKVLSLSREL DEAYDKIDDM
ENKRKALQNE LDDLVNTQGT ADKNVHELEK AKRALESQLA ELKAQNEELE DDLQLTEDAK
LRLEVNMQAL RSQFERDLQA KEEQAEEKRR GLVKQLRDLE AELDEERKQR TAAVAAKKKL
EGDLKEMETT MEMHNKVKED ALKHAKKLQV QVKDALREAE EAKAAKEELQ AASKEAERKV
KALEAEVMQL TEDLASSERA RRAAETERDE LAEEMAANAS KGTLMIDEKR RLEARIAALE
EELEEEQSNS EVLLDRSRKA QLLNEQLSTE LATEKSNSQK NENARALLER QNKELKAKLA
EIETAQRTKI KATIATLEAK IANLEEQLDN EGKERLLQQK ANRKMEKKIK ELGLNIEDER
RHADQYKEQI DKLNSRMKLL KRNLDETEEE LQKEKTQKRK YQRECEDMIE SQEAMNREIN
SLKTKLRRTG GMGLSSSRLT GTPSSKRGGG GGGDDSSVQD ESLDGEDSGN
//
