ID A0A1I8MRI4_MUSDO Unreviewed; 801 AA.
AC A0A1I8MRI4;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=[histone H4]-lysine(20) N-methyltransferase {ECO:0000256|ARBA:ARBA00012187};
DE EC=2.1.1.361 {ECO:0000256|ARBA:ARBA00012187};
GN Name=101900242 {ECO:0000313|EnsemblMetazoa:MDOA007714-PD};
GN Synonyms=LOC101900242 {ECO:0000313|RefSeq:XP_005176064.1,
GN ECO:0000313|RefSeq:XP_011294754.1, ECO:0000313|RefSeq:XP_019894478.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA007714-PD};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA007714-PD}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA007714-PD};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005176064.1, ECO:0000313|RefSeq:XP_011294754.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_005176064.1,
RC ECO:0000313|RefSeq:XP_011294754.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) +
CC N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:60344, Rhea:RHEA-COMP:15554, Rhea:RHEA-COMP:15555,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.361;
CC Evidence={ECO:0000256|ARBA:ARBA00000350};
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_005176064.1; XM_005176007.3.
DR RefSeq; XP_011294754.1; XM_011296452.2.
DR RefSeq; XP_019894478.1; XM_020038919.1.
DR STRING; 7370.A0A1I8MRI4; -.
DR EnsemblMetazoa; MDOA007714-RA; MDOA007714-PA; MDOA007714.
DR EnsemblMetazoa; MDOA007714-RD; MDOA007714-PD; MDOA007714.
DR GeneID; 101900242; -.
DR KEGG; mde:101900242; -.
DR VEuPathDB; VectorBase:MDOA007714; -.
DR eggNOG; KOG1085; Eukaryota.
DR OrthoDB; 11811at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0140944; F:histone H4K20 monomethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd10528; SET_SETD8; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR016858; KMT5A-like.
DR InterPro; IPR047266; KMT5A-like_SET.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR PANTHER; PTHR46167; N-LYSINE METHYLTRANSFERASE KMT5A; 1.
DR PANTHER; PTHR46167:SF1; N-LYSINE METHYLTRANSFERASE KMT5A; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51571; SAM_MT43_PR_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 665..786
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 53..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 135..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 229..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 424..523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 579..598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..75
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 497..512
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 801 AA; 87798 MW; 95F0A04F8B81ADE0 CRC64;
MVRRRTRACA NSKAPVELMT NGGSAAAALA NAAQLLEEQY FASPKRKDCK VEESACDEGG
RSSASSSPTN IQTEDANAHR TKHKSISPNK VKGGINGRTI GVPLATRSQT RTIENFFKAN
AAKQNKITNY MNGHDDSINS TDTPKTIQQP TLSASVTPPQ MTQQQQQHIE QQKRQINGDH
NYQQQQHLPP VISRRSLDHI VVPQEFIFDL SEDTNDSEHT DISDEAAMLH SGNDDDCAGH
MTNGLDFTTH RSSQRSDSHS SSHSSSNTSG TDNIFLQEPV LTLNVDKSPN QASSIVINKT
LEVQPKFSSP NQVNKSLEVQ AKFPSPTTLS ASVLHGRFNQ IVSLNASPAK DPPGSYEKKS
MELSCHDYAL LMMPENDNSS CDSGVAFHTT VTTTPQCNGT SNTEGPVDGP INQSVASAIA
SPAVAATNRR RKPATPHRIV CCPSPIKSQP RVNSPAGSPS PRKMASALSP RKSQRHVTTT
AMAAAGGGAA VVTAPNKTRR RLNQSPPKEQ KSALDAETNR QDDEPVVVIV DDDVEVEDDH
DVECENMATN TVDMKLNNLP PPSLVNGGSA SKSILNSAKH PTNQQNATNN KGKSTKAHHK
TKYTVQRPQH TALKHQAPQP LAATNGNREI TDCFPVRRSV RKTKTAVKEE MMRNLEQAIL
EERCEGLKIA YFEGKGRGII SERRFQRGEF VIEYVGDLIS TAEAAEREKR YALDENAGCY
MYYFKHKNQQ YCIDATEDTG KLGRLVNHSR NGNLVTKIVV VKQKPHLVLI AKDDIEAGEE
LCYDYGDRSK ESLLHHPWLA F
//
