ID A0A1I8MS75_MUSDO Unreviewed; 493 AA.
AC A0A1I8MS75;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Programmed cell death protein 4 {ECO:0000313|RefSeq:XP_005179552.1};
GN Name=101892144 {ECO:0000313|EnsemblMetazoa:MDOA007912-PB};
GN Synonyms=LOC101892144 {ECO:0000313|RefSeq:XP_005179552.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA007912-PB};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA007912-PB}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA007912-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005179552.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_005179552.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PDCD4 family.
CC {ECO:0000256|ARBA:ARBA00005497}.
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DR RefSeq; XP_005179552.1; XM_005179495.3.
DR STRING; 7370.A0A1I8MS75; -.
DR EnsemblMetazoa; MDOA007912-RB; MDOA007912-PB; MDOA007912.
DR GeneID; 101892144; -.
DR KEGG; mde:101892144; -.
DR VEuPathDB; VectorBase:MDOA007912; -.
DR eggNOG; KOG0403; Eukaryota.
DR OrthoDB; 1217702at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.180; -; 2.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR InterPro; IPR039778; PDCD4.
DR PANTHER; PTHR12626; PROGRAMMED CELL DEATH 4; 1.
DR PANTHER; PTHR12626:SF0; PROGRAMMED CELL DEATH PROTEIN 4; 1.
DR Pfam; PF02847; MA3; 2.
DR SMART; SM00544; MA3; 2.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR PROSITE; PS51366; MI; 2.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 182..303
FT /note="MI"
FT /evidence="ECO:0000259|PROSITE:PS51366"
FT DOMAIN 346..469
FT /note="MI"
FT /evidence="ECO:0000259|PROSITE:PS51366"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 40..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 110..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 493 AA; 54544 MW; 31505F4C690C73E0 CRC64;
MEVEAARQNG YASAESRESS VERELNGDIK AVEINGTAAA IAHSPKGQNG IIKKPHNVSA
DAHDQRIKRK GKRLIQRQNS RGESGSSSNG GAIGGIPIVM NGSAKDYVVP QRRWKNSRRS
RSGYGRGLPK KGGAGGKGVW GLPGSEALEE LYEDENDPNY DSETNDQNIV LSEVIPELTP
EEFFKLAEPI VLEYYEHGDT HEVAVNFDEI LTGNLRPYVT SVIVEIALDH KDSQREMTSV
LISDLYGRVI TAKDIEKGFE ILLANLPDLT LDTPDAPNLL GNFLARAVAD DCLPPKFVTK
PSEHGELNDH AMTAIRRADT LLHMKQGWAH LDNVWGMGGP LRPVKTITKQ MTLLLKEYLS
SRDIQEAHHC LRALEVPHFH HELVYEAVVM TLESLSQTTE EAMCELLASL DKACLVLPAG
MEQGFLRVFD DMADIVLDVP LAYIILDRFV ERCNRAGFIT DKILNNMPSR GRKRFVSEGD
GGLIKPPTLP LRD
//
