ID A0A1I8MUF2_MUSDO Unreviewed; 1083 AA.
AC A0A1I8MUF2;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Ral guanine nucleotide dissociation stimulator-like 1 isoform X1 {ECO:0000313|RefSeq:XP_005183528.1};
GN Name=101891529 {ECO:0000313|EnsemblMetazoa:MDOA008539-PA};
GN Synonyms=LOC101891529 {ECO:0000313|RefSeq:XP_005183528.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA008539-PA};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA008539-PA}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA008539-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005183528.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_005183528.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_005183528.1; XM_005183471.3.
DR STRING; 7370.A0A1I8MUF2; -.
DR EnsemblMetazoa; MDOA008539-RA; MDOA008539-PA; MDOA008539.
DR GeneID; 101891529; -.
DR KEGG; mde:101891529; -.
DR VEuPathDB; VectorBase:MDOA008539; -.
DR eggNOG; KOG3629; Eukaryota.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00153; RA_RalGDS_like; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF312; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE, ISOFORM E; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905}.
FT DOMAIN 388..526
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 565..827
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT DOMAIN 962..1054
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 163..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 275..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 821..862
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 891..946
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1054..1083
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 111..138
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 163..194
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 205..220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..256
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 834..862
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1083 AA; 122710 MW; CFF432C73D0848AE CRC64;
MNFSNTTSSS SSSYMCPTKS NKKIAVKVLK SPQNPTYQTT AKNQDFHLYQ TVDQLQQQQQ
PLQQKALMPP LDHATHIISH QHHCKHHHKH HLPQQPQSLP LYHQYEYQPS YETQAQRLSQ
AASELQHQKQ QLQQELQQHF HYNEYTNQNS FFYFDRKLSS TALSSPDSPL TSVTTPTNQT
PLHQKFSCHS SPQTPKHYHQ HHTAPKCLTQ RQSSTPCCMR SASPPPAPTG GRQSKATSTP
DRMAKTPTSS LTKPKKWRRP FSSYHSCDDL DATNNATNLN KSKNSTNDHH HSSPHQNSNE
KMVVASLKYL CACTGATLRN LSKRTKDLHK KNCYSYVKPT WRVWGEEKDT DIIYTVYLKK
VCYHRPTPSA ANPDSEDDIS YLEWEMVRVR FVKAATLERL VEALATDDGE LESTFINVFL
NTYRTFSTSK EVLGLFIKRF NTLTEKQRIE DIKHKDDVDY DPSATVHEQH KKTLVSVWKM
WLNGFPEDWN EENLRYLITF TSKHLPNSDL HSRALNQLEM ILRQQVYSKK SLPPWLGDQF
ADLYLAPEFQ RRACFLETYR FPRIDVRHFA EQLTRMDCDL FKKVISHQCL GATWSRRSQG
CCETVVATVT QFNEVLYRVI TSILIERALE PQERAVYIAV WIDIAQELRL LKNFSSLKAI
VTGLNSSAIY RLSKIWSVLP KEKLEIFQEL ARICSEDNNA SVQRELLIRE GTAKFAETVG
ENDRHMQKII QKQSTHTSHG TIPYLGTFLT DLTMIHQANP DTVGEDNLIN FEKKRKEFEV
LAKIKLLQGA ANTYNLEEDP LFNRWFYSMP VLTEEDAHTL SYQLEPPPPT APRKSNTSSN
MSSANSSILG HRKTDSIASN SSSGAGSQFY CEISSHNSSR HNSLDREAHN NHMSATSSVS
NLSLDSSNSG GGLNKSKMIH SQSSNGLLRS SHGSTSGSHT PTHVGSPLIN AQVVNSPGAN
ADFYIVKITL ESETMPQDGI VVYKSMMVKN NERTPQVIRN ALMKLGIEDD ADNYTLAQRL
PDKDVDLPRN ANVFYAVVVN KNFELRFILK PNPERMTNGG GSGVGGGIHG SSGGSRSSRS
SNS
//
