ID A0A1I8MV06_MUSDO Unreviewed; 4340 AA.
AC A0A1I8MV06;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:MDOA008710-PB};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA008710-PB};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA008710-PB}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA008710-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR STRING; 7370.A0A1I8MV06; -.
DR EnsemblMetazoa; MDOA008710-RB; MDOA008710-PB; MDOA008710.
DR VEuPathDB; VectorBase:MDOA008710; -.
DR eggNOG; KOG3595; Eukaryota.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 2.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF352; CYTOPLASMIC DYNEIN 2 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 184..633
FT /note="Dynein heavy chain tail"
FT /evidence="ECO:0000259|Pfam:PF08385"
FT DOMAIN 1076..1483
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1621..1968
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 2639..2881
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 2894..3227
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 3253..3480
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3722..3831
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 3868..4002
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
SQ SEQUENCE 4340 AA; 495365 MW; 9B2C9653BEF41935 CRC64;
MTQKTKFILN TSVEYFSGRL PTGLALDEQT ARILEFLDND ELTVISAVHN KAEDTIKFQH
RIPNDEVSLL FYKIPQVGST AKQTSSTTAG MDNHQPLGIL TLEGGLVKSI YNSVSRVFSP
HANVRKTEYS PELSGLLENL HVSLGSTLGL PQSGITSIKD EIKYWKQKLN QKNSSRIERE
AAQMFISVLE NIDQQISSIN TNGGMSIEEF LDAAHNNFDE LWRLPYQFPQ NRMADMMDVI
GNTLIEACLE QLLAEDIWSL NNSHVNSLMS QCIDTAESWL QLCDSLTRLF WPNYVKHPWV
GDAHIPKRPQ QFKERMLEIR NIKNLYKQIS TLLNDNEMKE MLLADSPFRE FNIFDTSAMG
QTKWNKALQN FEQLLQPIDE RIAAALKAQL HHHLSNPRQV IFIFSKYETL IQRPTVLELL
TIEREQFMQS LQILLHDLRK AMTDTNMEPD TGHLSVICNE CRWLKVVQYQ IQEIEKVSHL
ISGREGFEKI NKAVQEIKEE TESLLRTNFE IWCGQHTTAV KSGDLRLRDD QPVVKFEKEG
RQLMRVTFNP KLVTFCQDVR EFENMGYSVP AELRTAATHA AKYMCYARRL QQIATFHNTI
GDRMIPCQRP IMLKNAMELS KLVHSETVAW NDEESVLRYV NMLQAAVSKL STDNTLLVGY
HEQAKRTVAK LMNTDLFTQS QIWKDEMRHL RELVAHLERQ CFTNLDAFKL HWDHQLYKVL
EYQYIIGLVD MNNKLPDIHI KIAFRQRQLC FMPAEEEIRE RYYTQLRRFI ERPCGFRGLS
EKGPELFKTM VENNRHYFGP LYEKAEELFE KLGKFKKIWL PWVALGCVDI EELCGIHLQT
ADDWERNFKK CKSFSQKIAK IQSNEESIDC IVIDILPLRS DIEQISRRYW EALSNSLRSA
ILNDIAIIQD FLQNAIQFLE NIPMDESSIT ESGMKYEKIM TELPKVTETL EMVKAKDTCL
AGWCKERVSS LAGILSQWEK LQPLLENHAV ILQRQVDMIK EQAQTQIQNL RNEAEKFVLR
WESTLAELQA NEDATLEIFK ERQDHWHEIL KKKDQLLEEC GKFNMIFPED FLKPFDEIDA
KMNEQSKEWI VYDEYLTELN SIMDEEWAIY RRRPYILNEF ISKWEGSVHA SIDLPSKRIR
GSVEKLQSLL PLLQQLQSDS LTERHWARIF SLLKRDDIKN LHTFTLKNLL ENQTLLQQNS
QEISQIVRQA SSEQVVRQAL TEIDQWSVTA QLKLINQNDS SGQPISLIKD YQEVLNKIGD
NQSLLQSAKN SAAFEAFSDQ AELWESRLNT LDTILTSLNQ SQRRWVYLEP VFEAGTLKNE
EALFKRIDKD FRYIMREIQM DPRVVSLIKI NNITTIVKSL ETQLTRCQNN LMSYIMEKRN
SFPRFYFLGD DDLLEILGQA SKDPEVIQKH IKKLFPGCHQ LGIVQGNSLD DQRILYTIES
LKSAEGDVLK LRTPIEMKGP IENWLNSLVN TIQLTLREQI VQCCSTYPAD GFNENILKNY
VAQVLSTTRA IHFTRQCEKA IQTMALQKLQ QTLNAEIAKY SLWKHQTSDT LLQIKLRSLL
FDLVHYVTIV EELIDNNTMH LNDWHWLAQL KFYLSDGSGG SNIASSNATV IIRMVYAEFE
YSYEFLGNPN KLVSTRLTHK CYLILTQAMH MGLGGNPFGP AGTGKTECVK ALGAMLGRLV
LVFNCDENVD TESMALILTG LARCGAWGCF DEFNRLQEAT LSAISMLIQP IQCSLKDKLD
VVQIAGKNIK LNQHCGIFVT LNPAGADYGG RQKLPGNIQA LFRPIVMQQP EPGEIARVML
FVEGFKQPTE IAQRVVELFD MCAKILTQQR HYDWGLRELK TILLACGEGL RSITMNSAAS
QGSDGDDMEM LVVVQCLRTS TMSKLALHDV SRFEMLLHNV FPEISNVPGA YESSSSALSP
LQHAIREAFA ALGLCFNEMQ MIKCLQLYEQ LQKRMGVVVM GPPGCGKSTV ISVLRQALIT
QTSKSAPASL QQQQQQIRIH TISPKSMSRV QLLGRLDPDT RQWLDGVLTH TAVVVNAEPP
HIRSWIVCDG SIDPEWIEAL NSVLDDNKLL TLPSGWRIQF GNNVNFIFET DDVRNASPAT
ISRMGIVNMN NEDYPLKSIL EHQLSKYEFG DLLQSYIEEL YEPAMEWLEK EYAHSPLPCL
TRSWMLRALL LKLGDYTAVQ NRDAFTIAGC HAAREFLPVE RHNEFANWFY EKANLYVTNP
NQAELMYYNE ARNSVDVYES NTATDGGDFG DLVPTAAVKM YLDQLKGFLQ APDALPFLIV
GPPGSAKTLL IEHAVDDMSG YDLVIINCST QLTPAYIIHC IKQNCLAVSG VRGREYRPKQ
TRLVIYLKNL DLCYVDAWGC CEIVELLLQL VQRQGFYNDN LEWINVSGLQ ICGSISQQTT
TAATANASLV KIAPRYLAIN HMLHVGYPSQ QDMLAVIQRH LEHLLLGRGY GDRAAAHFKG
LNIQNVQYIS EGLMEFYAKT FVCVCVRSTP LQLQLSFGQT RGASGKTTET GNGSAGTGGG
GGVATLNTHY QFSPKLIIKT LTNLKYYPED AFNEALYCEL VSMFKDRLVC EEDADKFETI
LRHSLKKIAG KDKIFFVPKS TKHNVELQAL QHDEWLDEVQ KQVTICNSES FIIDAPTTKE
MLEQTAKIAR LLARNSSHIL LVGEAGSRQM DAIFAAATMQ QAKVQMLQGG CNYGLIDFYN
DLKLAMQMAS LENQCTCLVI EHCWLTYVPD IMKPIEAILE DSEILDLFGD DLESIASSLK
HSAQLEGFQE SLGSYFMKRA RENLHLIICL DPSSSNVDEY FQKYPALYRN MEMLYLRTMS
NETLNMLPKK YVETLCDMSM GSQQAKGKIS VSSYFSEILD IVFGRQAPLR FYQLIKSYYY
IYGNLSQEIS KRLEKLQHGV DKLASAHAVV DTLKSNASKQ ETALAEKRKL ANEALEMISS
TMKNANEQKT NMLELKKQTQ ISSEKLKERQ KEIQEELAEV EPILAEASTA VGQIKSEALS
EIRSLRAPPE TIRDILEGVL RLMGIRDTSW NSMKTFLAKR GVKEDIRSLD PARINPENCE
AVEKLLANKA ESFEMKNAKR ASAAAAPLAA WVKASVRYSK VIQSIKPLER EQKELQRNLD
AAEGEMQSLM TGLDDVDNRV KQLSAKLNSY TQEAAVLELK LEEARNTLKA AEILVQQLSS
EYQTWNLQLD EYKGAFKTLD SKSLMMALAL NYFAHMSLKQ RSSSLQQLST ELQLKDTFDL
EKTLLTEQEQ IIWESMGLAR DAQIIQNAAL LRQMLDLPFA SYPIPLLIDP TETAVNWLGE
YLKSKEKPYE IISQNNQKLN YNLELAIRFG KIFIVEDCQE LRPPLMQLLS YKVYMKFNKR
QIEVGTKLVD LHEQFQLVLV TKTPKLNIQP ETATYLNCIP FTVTAVGLSD QLMSKAIIMK
NPSLEQKRVE LLRNEGVLLK QRIELEDKLL EELSFAQGDI LKNEKLLKTL NEVKESSTVI
DNSLKESSAV KETLLADYTQ LKELCNKASV FYVNFLASYE LSSLVFIKLF LSALELHDIG
GTARTSGQME KEFYGQLVKG TFQYLARSIP KDRHLSLALF ICRTAYSDRI KDDEWELFVT
NFMSGADGSG ISSAGGMGRL QFSETFGKEA TMKLNILLRQ KPEMEDKLQL HNSNMWRQFI
EGQTQEVPVT TISNFEKLLL TLILRPDLVT YYMKLTSEEI LGLSIESIQQ PTIEQLVEES
SSAKPILMIT QTENDPASEI LSVALRLKGK DKYEELSIGK GMERKTMEVI RQMAELGKWV
CVKNVHLVPE WLIELEREYG EMKKTNDFRL WLICESTQGF SEAVMYKFIK VLYEYPMGIR
QKCKKMLQNY AIMEQDRNIL KEPKLMKIRV VLFLLMSVIQ ERRRFIPQGW SQKYEFGEAD
LKAALQIVRW LDSITLGGRV DWSIMQKLNE NVAFGGRINN LRDLRVLQNY LQTFFNNDSL
SSRWSPFDDK VIIPTSSQWS DYMNALSKLP AQDAPELFKL SKKSNASREI VYGMEILKEL
RMSFYGGSGG SLDDADPQNY QQLEKQIKPI LALWRKLAQN CSIDVTAQEL SDDQKSSKPW
IVFLYSELKT GGQGYQKIHT TLSQAYNATK ERQTNRNNNA GKSLNILALN QVPLEWQRIW
SGPANALDYI KAFMHRAMAT ETRYRTTQHL DFIDEIDLST VYNCQTLISS LKLINSHKQQ
KSCKNLQIAS HAIQSNSAYN QRNDGANDIQ VQLKVKPLRV NGATFSYGKL QITNNNDTSA
AATTENEQSP EFLITFKEKD EKNMQDLRTV SRGSTSGNTT LLPVYTNAKR EQLLCEFEVA
TTENVDTVLL SGAALIVGDY
//
