ID A0A1I8MWS8_MUSDO Unreviewed; 2724 AA.
AC A0A1I8MWS8;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 13 {ECO:0000256|ARBA:ARBA00019618, ECO:0000256|RuleBase:RU364134};
GN Name=101887516 {ECO:0000313|EnsemblMetazoa:MDOA009237-PA};
GN Synonyms=LOC101887516 {ECO:0000313|RefSeq:XP_005187018.2};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA009237-PA};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA009237-PA}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA009237-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005187018.2}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBUNIT: Component of the Mediator complex.
CC {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364134}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 13 family.
CC {ECO:0000256|ARBA:ARBA00009354, ECO:0000256|RuleBase:RU364134}.
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DR RefSeq; XP_005187018.2; XM_005186961.3.
DR STRING; 7370.A0A1I8MWS8; -.
DR EnsemblMetazoa; MDOA009237-RA; MDOA009237-PA; MDOA009237.
DR VEuPathDB; VectorBase:MDOA009237; -.
DR eggNOG; KOG3600; Eukaryota.
DR OrthoDB; 9289at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR009401; Med13_C.
DR InterPro; IPR041285; MID_MedPIWI.
DR PANTHER; PTHR48249; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR PANTHER; PTHR48249:SF3; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR Pfam; PF06333; Med13_C; 1.
DR Pfam; PF18296; MID_MedPIWI; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364134};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364134};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364134};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364134};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364134}.
FT DOMAIN 1957..2264
FT /note="MID"
FT /evidence="ECO:0000259|Pfam:PF18296"
FT DOMAIN 2302..2713
FT /note="Mediator complex subunit Med13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06333"
FT REGION 233..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 404..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 430..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 520..581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 617..858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1000..1020
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1036..1066
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1283..1382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2058..2159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..296
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 617..651
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 688..705
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 712..731
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 772..801
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 813..828
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 842..858
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2064..2115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2121..2148
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2724 AA; 293855 MW; B4DD1C6D220953C3 CRC64;
MTHQSHQTNG ASLEDCHTNF FALTDLCGIK WRKFVNSERP NASSDPLDDP ILRSYSRCMQ
ADILCVWRRV QSTRQDNSDP NAIFEVVNTS KVHPPLSLAA AKELWLFWYG EEPDLTDLVD
AELLKVAGNQ MLWNGTWERG LTYECRSLLF KALHNLMERF VLTKDIVRFG KWFVQPCTSN
ERIFCRSSQH LSFSFTFFVH GDTVCASIDL REHPAVRPLT KEHLAEAAAA FNAAASNANS
PEQTSPNSPN GATEVGAKEN AGSNSPAVAN NAAGGNSSSG SGNNSTTSNN ANGSGGTPKP
RKVILAPFGM AATLTGNSYK HNDPMAEKIL EDWASFFPLC NKENSEVPPV VEVIAGGHKM
YHPSIYVLVT DLDDMEEMEA AASQKSSLGS TSSAEAAAAI AALSSSANSH TNDTRKPLTE
SVTNNNKLAS SAANAMTTSS SSPTSNAATT KSSLAHMIER LKIDHTKVQQ YYDTQTQNFT
CNTTNTHAPP QAACEMPERV WQDCVTNTLH LQNGTICNTA TSSSGTTTSA STSNPNNNTS
SVSPSLNTMM GSGNDNNSTT IPMNTDAGDQ TDNASNMMDI KPNLNTTTTA LSQSQQQQIW
GFVDPTQKST CICTKSSQTS TSLSGQTPGN GTPLQGGISS YSRNSIMDCM QIPSVGSPGT
PAPSPHPNSA LSQPTSVPPA DQLLMSPRAP TSVPNLQQPT TPIDHLLDKN TPAPTPTDQH
DNKSITASPY IHPTPSVEAP PSVEGMHCGN LGGGNGGMGP ASVGAQPPSV GRCTPTLHQQ
QQQHQSSQPT QAQQQCGSIS VKKFDVQPGT PLLLGSGGNN NSSNPVAGGV VPTDDKPDSV
KTMPNSRTAL PNNNFSRNNT APSATNAMHD FYNLCKPPKI SVKDIDAIAN EDCLKLENLY
DFPTQDIWAN HPAKRFKPNE ISKHNRVPRT KALYERHTHI KPLLLSPRSL YGDQLLAIDP
TAAAAAGTGS SGMEGSGGAG NCGMVGTGLV GIAPNPMANN KINNNENSGG GMMNSTTTAS
GGSIFEELDI KTEVPPAVGA SSISPSKDSK SGIGGNLFTV EGLNPSPNDL EQLFETSSND
ECGSVQIHTP PDSNNPSNGC AVTTNTIDEL KRSTNSGLVG AVNVQGNSAA VMAALQNCNS
VVNATTSGMA SLNNSGGSLT GGGPGGLGVG PNTIQAEDLT KMFPTPPSHE QHHPNSSPCQ
MDIQMTDLNV MTSTNIMGGQ TLDTGLGISA MTKVKQEYSS ELGSPIEGPI EDWTYVYRPP
AQAIFVGSSK YAPLTNLPSQ SMAPLSMPSN CRYKPSWQQP RSAHQQQQQQ QQQQQHMQQQ
QQQQLQQQQQ HQQLHELLSA APRTPLQQQP RTPLGPMSSS PMHNTTVPTP LSSGGGGSSS
LLLNQLNCPQ AALTNNPLTM QHIMQRPGMS PISPATHVPF PHTSPMMQQH RQTPIHPPPP
YEVAVASPAL STASSTPAYL NKQYHSQEPP QTPQSVPNHI QTIGGPPSVQ GNNRESSNMG
FYAPANNINS IIQELPEVSS VIVNILLYDT ALNVFRDHNF DSSTVCVCNA DNQRIGNIRG
SDSGVYVPLP GTSFNPTAPS LSTANAMRAL SAFGGGGSSM GVALGSTAGG GSILGSVSAA
GIANSLDSPA SLAGAGSSSS TTPSTATPAN NAQQYITGYV DDDAVECTCG FSAVINRRLA
CKAGLFYEDE MEITGIAEDP GRHKKHSLLT LLINLSSKAN NNSSNNNNTN SNGIVDKTAE
QVAYSLFDLL LEQCSIIQTS SSAIHRALQR HRRRLSKRSQ KPQSVAGIVN VLEYIDANDI
IALALEQARL AYDSSNRMDI MEQQMIPFSS HRKTSNNTQV ALALTGRINV HKWPYIPVGF
SRSNKDIVST MKSIQPMLQN AFHVKSRTAG SRDATYTVSG PLTWRQFHRL AGRASGQCEP
QPIPSVIVGH DKDWISVAPP AIHYWDKFLL EPYSYARDVV YLVMAPDNDY VLSKTKSYFK
ELSTIYEMCK LGRHTPICGW NGLLAVQQRP ANDKAFSTNM DNWLKSLDDA RLAEQLRLYA
HAFQHQLAPY LNRVPGDKTL LNPPETSARC SQGYSTATSS STNSSSSSSS SFMMGGVNNS
NTTGGMDNTG QGAGAADHSQ PMDTNEHSQH ATGTNSSSDS QGNSSGDAKP TDLKPDVKPP
LVLGDPLGVA DCLEEVNPSA IVLYVVEPFT FGSDSPELER LACIALLRMY SELLKMIPDS
VKAHINIQII SLESILELGR SRSRKRTSDE IKCLALNIFS QCKRHMVHAQ SVKSLTGFGT
AANVEAFLKT KDEKNRRPYK MYTPPYILAP MHEKNEKTDF SRAAWGGMRG SPNEQKYSVM
YCNYCLSEDQ SWLLATVTDD RGEMLEKVCI NIDVPNRTKR RRAPARRIGL NKLMDFILGL
ISQTTQTWRL VVGRIGRIGH NELKSWSYLL GKQNLQKATK QLRDMCKQCQ LMYPPTILSA
CLVTLEPDAK LRVMPDQFTP DERFSIQNPL STPQDVTCTH ILVFPTSAVC LSFTRQFPNE
PQVDLDEDFI NFGNDEDEND VFKDADLMDD LLGQWDGGGT ARGMSNHNSP DRMEDNRSWQ
SVGGNNFNTN QHQDIEEVGS INQQPLAVGY MVSTAPTGRM PAWFWAACPH LEDVCPVFLK
TALHLHVPNI QTTDDILNST NAHSSATDHP LDSTLTADVL RYVLEGYNAL SWLALDSNTH
DRLSCLPINV QTLMDLYYLT AAIT
//
