ID A0A1I8MX43_MUSDO Unreviewed; 788 AA.
AC A0A1I8MX43;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Spondin-1 {ECO:0000256|ARBA:ARBA00019594};
DE AltName: Full=F-spondin {ECO:0000256|ARBA:ARBA00030964};
GN Name=101894809 {ECO:0000313|EnsemblMetazoa:MDOA009319-PA};
GN Synonyms=LOC101894809 {ECO:0000313|RefSeq:XP_005181918.1,
GN ECO:0000313|RefSeq:XP_005181919.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA009319-PA};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA009319-PA}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA009319-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005181918.1, ECO:0000313|RefSeq:XP_005181919.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_005181918.1,
RC ECO:0000313|RefSeq:XP_005181919.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR RefSeq; XP_005181918.1; XM_005181861.3.
DR RefSeq; XP_005181919.1; XM_005181862.3.
DR STRING; 7370.A0A1I8MX43; -.
DR EnsemblMetazoa; MDOA009319-RA; MDOA009319-PA; MDOA009319.
DR EnsemblMetazoa; MDOA009319-RB; MDOA009319-PB; MDOA009319.
DR EnsemblMetazoa; MDOA009319-RC; MDOA009319-PC; MDOA009319.
DR GeneID; 101894809; -.
DR KEGG; mde:101894809; -.
DR VEuPathDB; VectorBase:MDOA009319; -.
DR eggNOG; KOG3539; Eukaryota.
DR OrthoDB; 5404502at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00109; Kunitz-type; 1.
DR CDD; cd08544; Reeler; 1.
DR Gene3D; 2.60.40.2130; F-spondin domain; 1.
DR Gene3D; 4.10.410.10; Pancreatic trypsin inhibitor Kunitz domain; 1.
DR Gene3D; 2.60.40.4060; Reeler domain; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 4.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR InterPro; IPR002861; Reeler_dom.
DR InterPro; IPR042307; Reeler_sf.
DR InterPro; IPR009465; Spondin_N.
DR InterPro; IPR038678; Spondin_N_sf.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR044004; TSP1_spondin_dom.
DR NCBIfam; NF038123; NF038123_dom; 1.
DR PANTHER; PTHR11311; SPONDIN; 1.
DR PANTHER; PTHR11311:SF23; SPONDIN-1; 1.
DR Pfam; PF00014; Kunitz_BPTI; 1.
DR Pfam; PF02014; Reeler; 1.
DR Pfam; PF06468; Spond_N; 1.
DR Pfam; PF19028; TSP1_spondin; 1.
DR Pfam; PF00090; TSP_1; 3.
DR PRINTS; PR00759; BASICPTASE.
DR SMART; SM00131; KU; 1.
DR SMART; SM00209; TSP1; 4.
DR SUPFAM; SSF57362; BPTI-like; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 4.
DR PROSITE; PS00280; BPTI_KUNITZ_1; 1.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 1.
DR PROSITE; PS51019; REELIN; 1.
DR PROSITE; PS51020; SPONDIN; 1.
DR PROSITE; PS50092; TSP1; 4.
PE 4: Predicted;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..788
FT /note="Spondin-1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014271629"
FT DOMAIN 12..186
FT /note="Reelin"
FT /evidence="ECO:0000259|PROSITE:PS51019"
FT DOMAIN 183..373
FT /note="Spondin"
FT /evidence="ECO:0000259|PROSITE:PS51020"
FT DOMAIN 641..691
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
SQ SEQUENCE 788 AA; 88322 MW; 1FDFCB5D22A2CB0A CRC64;
MLLAKRSAGL FYFCLIAVIC VTCVNACTRA PTHLPHGRRT RGDNGYRLIV ADGPNGYVPG
KTYNILLLGS RTHMKVQHFT HFSITAEAHI GGRRPIPANP QRVGRFQLFS DSLTKFSDRC
VNTVAEADDL PKTEIQVMWV APEAGSGCVS LSAMVYEGPR SWFSDDGQLT QVICERKVDH
TTVQKECCAC DEAKYSFVFE GIWSNETHPK DYPFAVWLTH FSDIIGASHE TNFSFWGENH
IATDGFKSLA EFGSPSALEA ELRSKGPRLR TLIKAAGLWY PNVNANTSST FRVDRKHNKV
SMVSMFGPSP DWVVGISGVD LCTADCSWKE SMDFDLYPWD AGTDSGITYM SPNLETQPRE
RMYRITPMYP EDPRAPFYNP QTKTMVPLAK LYLRREKIIS RNCDDDFLQA LQLEVSDDTE
DQDTRAECQV TDYSPWAPCS VTCGKGIRMR TRQYVNPEKA EMAKCARQLV SKEMCAAAIP
ECGAQQDDDD EGENLANSSS LVNENGEGTG ICQTTPWSGW SDCSASCGIG ITMRTRTFLN
HLGRKRCPHI TVVEKQKCMR PECTFEEVEL PDPMCPTTQW SDWSPCSATC GKGVTIRTRV
LLLEEGSVKE ECTKRMDLNQ QKECTLAQDC NINFEMAKEI CASRFDSGPC RGSYMRYGYN
KDTGRCETFT YGGCRGNRNN FLTENDCMNT CGRLANNQPT QITTSRPAPL LNIPSYRPYN
TGIITANNDD SIPEGCIMSE WSNWSECSVR CGLGYSERYR YVISEPKNGG QPCPKRTVKK
RRCTMTDC
//
