ID A0A1I8MXL4_MUSDO Unreviewed; 2845 AA.
AC A0A1I8MXL4;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Kinesin-related protein 4 isoform X1 {ECO:0000313|RefSeq:XP_005183099.1};
GN Name=101887902 {ECO:0000313|EnsemblMetazoa:MDOA009450-PA};
GN Synonyms=LOC101887902 {ECO:0000313|RefSeq:XP_005183099.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA009450-PA};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA009450-PA}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA009450-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005183099.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_005183099.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR RefSeq; XP_005183099.1; XM_005183042.3.
DR STRING; 7370.A0A1I8MXL4; -.
DR EnsemblMetazoa; MDOA009450-RA; MDOA009450-PA; MDOA009450.
DR GeneID; 101887902; -.
DR KEGG; mde:101887902; -.
DR VEuPathDB; VectorBase:MDOA009450; -.
DR eggNOG; KOG0242; Eukaryota.
DR OrthoDB; 3456149at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0015630; C:microtubule cytoskeleton; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd01374; KISc_CENP_E; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47968; CENTROMERE PROTEIN E; 1.
DR PANTHER; PTHR47968:SF36; CENTROMERE-ASSOCIATED PROTEIN E; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000694905}.
FT DOMAIN 6..322
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT REGION 905..933
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1148..1176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1557..1577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2567..2598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 338..378
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 591..674
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 706..898
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 937..1009
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1682..2083
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2126..2327
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2363..2397
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2430..2488
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2514..2566
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2666..2696
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2767..2827
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 2567..2591
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 83..90
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 2845 AA; 330760 MW; F139DC640B96E4DE CRC64;
MSGKNSIQVG IKVRPLLKKE KDQQPLWRVV NNSIQQVDSQ SDPYYFDHIF DQDATNQQIF
DKMAKHIVHA AIKGFNGTIF AYGQTSSGKT YTMMGDEDNP GVMVLAAKDI FRELEQLSVH
RQFLLRVGYI EIYNEKIFDL LDKKNQDLKI HETGNGLITV NCEERIITSE EDLLYYLTQG
SKERTVGETN MNERSSRSHA IFRIIIESRK VDRSEDDAVI QSVLNLVDLA GSERADQTGA
RGTRLKEGGH INKSLLFLSN VIKRLSENED DKYISYRDSK LTRILQDSLG GNALTAIICT
IKPTAIEETQ STLSFAMRAK SIKNKPQVNE TVSDATMMKR LEREVKMLRL RLAEEQKKNE
SQIKVRQLEQ RIRNEDLKII SCNSLHRNRE KRRRTWCPSS NLNTSNIPSA LPVPSALPVP
SFHNGANNGG APPSRLQPPK SFYLTPLITC RPTEPPPAPM LSSGEIITEI DEEFAPAEMI
NFDRLSPLLT PKTNMPRCSM TPKVTSNSKL TLESVEQDLM ELQSFTNLED RYEVQHETDL
SLKQMVNSLT NRISLLESER IEYIQLKDEI TVTREHLTEY ETKCDALQIQ VSKLTSVNKS
ANEKIAKYET ELAVLKKTNE KLEMENREAV NIEFEFERHK NKAKLRENEL LEALKDKERE
VTQLEKSLKT VANEKFTNSK EELLQLSLTE SKIDENGKIC VKCEDLQRLL ADNEKVTQEF
TKLTLEYEQL RINYQEIEKD NQESKLKIEE LEELQRRERS ECEKLQNDLQ VLREKLQDIQ
REYEQVSSEN SSKTEECMAL NHQVELARQE MVVLQEKYNS LELSWQEQQQ SLKDIEQQYA
EIENKYKHLQ LEYEQLEESS KDQSSATKTD CERLQRENIE LQSEIVELKH KVQDVQQQLL
ERGVAAAAEE KEKEQQQEGG EEEEGEQIPN GNATMDTANL LKENEQLKSQ LLDLQTQFDG
LQREYDDLSN QLMDNLQESD TLKEQNTKLE QEVKVLKQNS EEVSKAEAEI CELKSQLERV
LSSERRSMLC TPSPGRNSSM RSSGVCIEEE YGEFEGSPCP EDDLLKKFQQ LSESLTQIEL
EHQNGQRRIF KTPKNQAGSS QTPNYKLYLR NISGVNKIQK NFLDEMENIQ LQGSFKQHSF
HIVEINAEQQ SEMDEEEKKG QEQSNEGART ANNCDDAETN GCENCMEFIV RLREQISQLQ
LLNDEERQSN KALLENTERT LCEMREQINQ LSAELLEKSI FVERCACKTY QQQIETLEKE
KADMTVVFEE LQEKVNNCTF DSSMLMMNCT LNGETKSAPP VVGDLRKELE QLQAKEREMS
ETLESQTIML EELTQRNLDL ESDMKAAQDQ YEEKEKEYKE RCNQLQLEML EKLEVSANEY
RDNMKKYNKE WEDRKDAYEA TIKEQEEQLQ QLKQEQEETT KRAQELQEQM EKVKNEYNQL
QSEYLQSKDE GGDGDHVRTM EELINLKAQY AELQNQREEA LQQLKLVEET CQSVKVELQQ
LTRNFEELQA QRLQLQEQCR QQEEALREYE AEQHNKDQLQ KLQDEYNTMH SQLQQALDEM
KEKEDISQKS KQELEEEREK LTQLQSEYHG IQEEKNLLEK EFENLQEHRT QLQLELDRAM
ETLKENEEMS TAVSQELVKM RQHFATMETQ NFDLENPPKS SSEIFKELQV YLDKGVVLLK
EKVELDQQLL QLREDYKQLN EKHNEIVKEK LTLCDEKEEI QLKLSQLEEK LNGNEAQKDV
LQQLTEEKDQ LAMERQQILQ KLQQAENQIQ EYCKEDSARE ELIQTFQAKI ATLEALQNEK
DDLDSQKSEL NGKLERLIEE KESLEKKLTE LQEANENQEK LSDMHLNTLR EEKSALEEQK
MQLEEQLKKL ESVVEEKTSL ENRLAELSEL EIEKALLEDK LQAMTTVIEE KTSLETKLAE
LSEEKSLLEE KLKTFEKVVE EKSSLEVELK ELQSQRIALE DQVKILECVM EEKSSLESKV
NELSEMEKQK MLLEGNVKNL EAVVKEKDAL EEQIQTLREI DEKHQEENQK LKSEYEELQQ
RTKSLEEQLQ LDQVEKEKLQ EELQILNGKI ASKNEELSAF NERESTQLKA YEDLQTALNT
LTTTSSSLEL EKCNLEQQLQ QCNTELQMLR GEQGALETQL NQLTEEKKSL SEKCCVLGEE
VATLKDQLKC LKEKEKVEEL LEQMIQEKAD LSQNLRLTNE KLEAKQQELD LLQQQFDANT
RQMEMLKSSL SSASKKNETL ELELQKYQQL AEEKSKLEAS IVDLKNAHAE RLCSLQQERD
TIQITISKYE RDISQYKQQE NTFSQKIEKL SQELHETRSK AKSYETLLVE HEEVERSLNV
AMQQTTDLSN EIKNLKSLMA SNAQLHEETN RKQTEQIQQL ELQLLQASNS ERELLSKLTT
LQEQLQSQQT SLQHETIELK NSLGELQLKY TSLQTSNEQL QSVNQQLEQQ LHEANLKLQE
GAMLQNQLAA LKTDYVEMQR KMEATVEEAG RCSRNLRDDL QHHKDLLDRQ LESYNALRTE
MDLKERAFDE EKQQLTNTIE TLQATTTSLE EKIREITINN LNLERQSLNT SGNTSMDVAN
TSSSSPRPRK SLDALNISDK RKNRRLSTFD ERRCGITQEK ETMTDPMVAC KCEELDRKLK
ECERNLFIRE SQVTALSMEL KNHPLKDEKA ALMKRLQEEQ EKLKRYKQKI YEQTQKTEKA
MAALAQVQAQ LQAQAAEKKA ATTSSESNNT PVIVVADTVN VETQTDGDIS TSFNTLQGKY
NDLINICRYR KDRIKELEER ISQKENTDGN SMNTLEATQM KMLKSQCDSM KKELNLLREK
YENAKIVLHT RREEIQRLRS QLGQS
//
