ID A0A1I8MYG8_MUSDO Unreviewed; 671 AA.
AC A0A1I8MYG8;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=SPARC-related modular calcium-binding protein 2 isoform X1 {ECO:0000313|RefSeq:XP_011292633.1, ECO:0000313|RefSeq:XP_011292649.1};
GN Name=101901120 {ECO:0000313|EnsemblMetazoa:MDOA009721-PF};
GN Synonyms=LOC101901120 {ECO:0000313|RefSeq:XP_011292633.1,
GN ECO:0000313|RefSeq:XP_011292649.1, ECO:0000313|RefSeq:XP_011292680.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA009721-PF};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA009721-PF}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA009721-PF};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_011292633.1, ECO:0000313|RefSeq:XP_011292649.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_011292633.1,
RC ECO:0000313|RefSeq:XP_011292649.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
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DR RefSeq; XP_011292633.1; XM_011294331.2.
DR RefSeq; XP_011292649.1; XM_011294347.2.
DR RefSeq; XP_011292680.1; XM_011294378.2.
DR STRING; 7370.A0A1I8MYG8; -.
DR EnsemblMetazoa; MDOA009721-RC; MDOA009721-PC; MDOA009721.
DR EnsemblMetazoa; MDOA009721-RE; MDOA009721-PE; MDOA009721.
DR EnsemblMetazoa; MDOA009721-RF; MDOA009721-PF; MDOA009721.
DR GeneID; 101901120; -.
DR KEGG; mde:101901120; -.
DR VEuPathDB; VectorBase:MDOA009721; -.
DR OrthoDB; 5388426at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd16234; EFh_SPARC_SMOC; 2.
DR CDD; cd00104; KAZAL_FS; 1.
DR CDD; cd00191; TY; 2.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 4.10.800.10; Thyroglobulin type-1; 2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR019577; SPARC/Testican_Ca-bd-dom.
DR InterPro; IPR000716; Thyroglobulin_1.
DR InterPro; IPR036857; Thyroglobulin_1_sf.
DR PANTHER; PTHR12352:SF3; NIDOGEN-2; 1.
DR PANTHER; PTHR12352; SECRETED MODULAR CALCIUM-BINDING PROTEIN; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF10591; SPARC_Ca_bdg; 2.
DR Pfam; PF00086; Thyroglobulin_1; 2.
DR SMART; SM00280; KAZAL; 1.
DR SMART; SM00211; TY; 2.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF57610; Thyroglobulin type-1 domain; 2.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS00484; THYROGLOBULIN_1_1; 1.
DR PROSITE; PS51162; THYROGLOBULIN_1_2; 2.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00500}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..671
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014271599"
FT DOMAIN 25..80
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 78..142
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT DOMAIN 438..505
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT REGION 143..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 317..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 636..671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 317..372
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 636..663
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 122..142
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
FT DISULFID 475..482
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
SQ SEQUENCE 671 AA; 76681 MW; 74EE7BBF7A2156A3 CRC64;
MILRSVFLFA ICMRFVYGGN VKRPELTISE CAAKLGECDE SKGRPVCGTD DQTYPTRCHL
LRVQCSGHQV SLKYRGPCKA CAEAREYALR HRNKYPPKFI PRCKSDGTYA PIQCLMDKGC
WCSDSMGTPI NDTTVRTGKP KCREFSKANV RRSPSRNNGG NRKRPCTQED RATFNSHLIR
VFQSEYIRSK STQYQREMAS GSRSKASSLD TFNPPSETEV MDWKFSNLDV NRNQMLDKNE
YRELKKLVKR AVKPKRCGRA FGKFCDVDSD ERLSRLEWNS CLSKDGSNRH LLIMGQKHNN
TTTTKNNTKH RKNNIIHSNT ANTNNNNSNQ QQHHHQQQQQ FTSTSSQQQQ PHHHLNNNIP
HHHNNNNNHQ NRLRPDSYED NESNAAADND EDSSSQHLDY EDGDDYEETD DDGSSTKFPS
IYILKPPTEI STKESDIESD CLADQAAALE EKKLGNTFYY VPDCTIDGRY QRIQCYNSTP
YCWCVNEDTG KTIPGTWVKH RRPQCDSLYT VTRAMKGCPE ERKVVFLKDL KEFLKTKIIT
GSYAGVNTTN FSSEDERIAT LSFVILDKNK NSAWEKKEWK TFRELVNNVN NLRKCGRKMP
RYCDVNGDKK ITLNEWIGCL QATRLDITAT NVGAQNDAKQ QNTSTSDTNS SSSSKTPKLS
GSNPLEQYLK D
//
