ID   A0A1I8MYP9_MUSDO        Unreviewed;       904 AA.
AC   A0A1I8MYP9;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   SubName: Full=CD109 antigen {ECO:0000313|RefSeq:XP_005182172.1};
GN   Name=101894811 {ECO:0000313|EnsemblMetazoa:MDOA009775-PA};
GN   Synonyms=LOC101894811 {ECO:0000313|RefSeq:XP_005182172.1};
OS   Musca domestica (House fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC   Muscidae; Musca.
OX   NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA009775-PA};
RN   [1] {ECO:0000313|EnsemblMetazoa:MDOA009775-PA}
RP   IDENTIFICATION.
RC   STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA009775-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_005182172.1}
RP   IDENTIFICATION.
RC   STRAIN=Aabys {ECO:0000313|RefSeq:XP_005182172.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_005182172.1; XM_005182115.3.
DR   STRING; 7370.A0A1I8MYP9; -.
DR   EnsemblMetazoa; MDOA009775-RA; MDOA009775-PA; MDOA009775.
DR   GeneID; 101894811; -.
DR   KEGG; mde:101894811; -.
DR   VEuPathDB; VectorBase:MDOA009775; -.
DR   eggNOG; KOG1366; Eukaryota.
DR   OrthoDB; 2970602at2759; -.
DR   Proteomes; UP000095301; Unassembled WGS sequence.
DR   Proteomes; UP000694905; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   Gene3D; 1.50.10.20; -; 1.
DR   Gene3D; 2.20.130.20; -; 1.
DR   Gene3D; 2.60.120.1540; -; 1.
DR   Gene3D; 6.20.50.160; -; 1.
DR   Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR   InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR   InterPro; IPR011625; A2M_N_BRD.
DR   InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR   InterPro; IPR011626; Alpha-macroglobulin_TED.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR019742; MacrogloblnA2_CS.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   PANTHER; PTHR11412:SF176; GH01829P-RELATED; 1.
DR   PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF07703; A2M_BRD; 1.
DR   Pfam; PF07677; A2M_recep; 1.
DR   Pfam; PF07678; TED_complement; 1.
DR   SMART; SM01360; A2M; 1.
DR   SMART; SM01361; A2M_recep; 1.
DR   SMART; SM01419; Thiol-ester_cl; 1.
DR   SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR   PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW   Thioester bond {ECO:0000256|ARBA:ARBA00022966}.
FT   DOMAIN          172..262
FT                   /note="Alpha-2-macroglobulin"
FT                   /evidence="ECO:0000259|SMART:SM01360"
FT   DOMAIN          811..902
FT                   /note="Alpha-macroglobulin receptor-binding"
FT                   /evidence="ECO:0000259|SMART:SM01361"
SQ   SEQUENCE   904 AA;  102891 MW;  3AEC8E2A85DC46BB CRC64;
     MKYIPLPANT KSHIIKIKPA VDMIPRCYVY VHYIINGDLR YCELSLKFPN EFENTVSISA
     PSIAKPGQEV QLDLRAKPNS YVGLLAVDLS VYLENPDFNI DRERIFRELV YDLTFSGVDV
     IYPGQISGLI TLTNANYLYE TSIEKYERPR SKIEYDTFRT ERLKIRSKFP ETWIFMDFDN
     VSEMTQLTFN VPDTITTWLI TAFSVNDESG FGMMSEPTNL TVFKTFFIST NLPYSIKSGE
     VVKIPLVIFN YHNKDLDTRI TMNSLDGDYD FIDELTMQPM ASTTKSQDII ASANGGNTLH
     FFIKPKKLGV IRINIKATNY LYNDAILQQL LVEPTGTMEN HNKDLFINLK KSEQLFRSSI
     DIDVPENHVA DTEFLQLSVS SDILHTTLDN LDSLVQLPTG CAEQNMVNFA PNVLVLDHLR
     ATRKSSENSD LVKRATGHLE VGYQQELSYR HYNGAYSVFG PNAQTEESTW LTAYITRFFI
     KAQRYAGVEN RIIQSGLHFL ESKQLPSGEF QYTGYLFHSA HQDRYGFTAF VLMTFLESSK
     SSRNYKAVIQ KGVNYLVDNI NNINDTYALS LVSVALQMSK SEQANQVLAK LQQKSHSKKG
     LKWWQSSNAE HSNDVEITAY ALMALLGTNS LDNINIVKWI LEQRNKAGGF KTTHDTVVAL
     QALIRFNQKY PSNNDTLLKF NYAALDAQGL EVGNGFLGID PSNSKIWQKI ELPKTTRLLQ
     LKIEGEGNAL VQLAYHYYVP LETDVESITL DDDSITATTF AKSSSVIHRR ETPKQKSFAI
     SPMAKLTSNA VMELEVCFKF KPSKELKHRQ TNMVIMEINM PSGFVVSPES MHDLQEEEFV
     ARVEVKDSNT KCLAYFKHLQ ADDDEKCLSI QADNMHEVLQ LEPASIIMYD YYIPENRDTI
     AYQM
//