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Database: UniProt
Entry: A0A1I8MZR4_MUSDO
LinkDB: A0A1I8MZR4_MUSDO
Original site: A0A1I8MZR4_MUSDO 
ID   A0A1I8MZR4_MUSDO        Unreviewed;       512 AA.
AC   A0A1I8MZR4;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   18-SEP-2019, entry version 22.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|VectorBase:MDOA010060-PB};
GN   Name=101900907 {ECO:0000313|VectorBase:MDOA010060-PB};
OS   Musca domestica (House fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Muscoidea; Muscidae; Musca.
OX   NCBI_TaxID=7370 {ECO:0000313|Proteomes:UP000095301, ECO:0000313|VectorBase:MDOA010060-PB};
RN   [1] {ECO:0000313|Proteomes:UP000095301, ECO:0000313|VectorBase:MDOA010060-PB}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Aabys {ECO:0000313|Proteomes:UP000095301,
RC   ECO:0000313|VectorBase:MDOA010060-PB};
RX   PubMed=25315136; DOI=10.1186/s13059-014-0466-3;
RA   Scott J.G., Warren W.C., Beukeboom L.W., Bopp D., Clark A.G.,
RA   Giers S.D., Hediger M., Jones A.K., Kasai S., Leichter C.A., Li M.,
RA   Meisel R.P., Minx P., Murphy T.D., Nelson D.R., Reid W.R.,
RA   Rinkevich F.D., Robertson H.M., Sackton T.B., Sattelle D.B.,
RA   Thibaud-Nissen F., Tomlinson C., van de Zande L., Walden K.K.,
RA   Wilson R.K., Liu N.;
RT   "Genome of the house fly, Musca domestica L., a global vector of
RT   diseases with adaptations to a septic environment.";
RL   Genome Biol. 15:466-466(2014).
RN   [2] {ECO:0000313|VectorBase:MDOA010060-PB}
RP   IDENTIFICATION.
RC   STRAIN=Aabys {ECO:0000313|VectorBase:MDOA010060-PB};
RG   VectorBase;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   VectorBase; MDOA010060-RB; MDOA010060-PB; MDOA010060.
DR   Proteomes; UP000095301; Whole Genome Shotgun Assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 2.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000095301};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095301};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM      6     24       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     74     97       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    160    184       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       40    189       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      196    369       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION      401    421       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      461    512       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    461    503       Polar. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   512 AA;  58383 MW;  B28DFFF6F8F2BC84 CRC64;
     MFLIVAFVFL IIFTYFIVQT LFWYRQTRFS SRRIRKRVIF KHGDCNVVQG NVAKRRRRYL
     QDIFTTLVDA QWRWTLLVFA CSFLISWAFF GLIWWTIAYA HGDLEWIDNR DNRPELIQNM
     THTMCVTEVR SFISAFLYSI ETQHTIGYGN RFVTEECPEA IFTICLQCIT GVFIQAFMVG
     IVFAKLSRPK KRAQTLLFSR NAVICHRDGV PCLMFRVGDM RKSHIIEAHV RAQLIRKKVT
     KEGEVLPFYQ QELKVGADGG EDRLMFIWPT TIVHKIDRHS PLYMLSASDM LKERFEVVCM
     LEGVIESTGM TTQARSSYLP SEILWGHRFV NVVSFRKETG EYEVDYTLFN NTYDVDTPLC
     SSKELDDLKE EYSKNHKAGL DRALSAGLLK HISSVASVDH MDPASDESLD SGRLHTRSNS
     IPNGALATEL EPLNNNTPSF TVGGSSILPS ITTNFQSINE KINSTNGSST HNNNNNNSGS
     NINHSSSNTS LKAKSSRRLS IKQDQLPVDS LC
//
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