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Database: UniProt
Entry: A0A1I8MZS0_MUSDO
LinkDB: A0A1I8MZS0_MUSDO
Original site: A0A1I8MZS0_MUSDO 
ID   A0A1I8MZS0_MUSDO        Unreviewed;       490 AA.
AC   A0A1I8MZS0;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   18-SEP-2019, entry version 22.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|VectorBase:MDOA010060-PH};
GN   Name=101900907 {ECO:0000313|VectorBase:MDOA010060-PH};
OS   Musca domestica (House fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Muscoidea; Muscidae; Musca.
OX   NCBI_TaxID=7370 {ECO:0000313|Proteomes:UP000095301, ECO:0000313|VectorBase:MDOA010060-PH};
RN   [1] {ECO:0000313|Proteomes:UP000095301, ECO:0000313|VectorBase:MDOA010060-PH}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Aabys {ECO:0000313|Proteomes:UP000095301,
RC   ECO:0000313|VectorBase:MDOA010060-PH};
RX   PubMed=25315136; DOI=10.1186/s13059-014-0466-3;
RA   Scott J.G., Warren W.C., Beukeboom L.W., Bopp D., Clark A.G.,
RA   Giers S.D., Hediger M., Jones A.K., Kasai S., Leichter C.A., Li M.,
RA   Meisel R.P., Minx P., Murphy T.D., Nelson D.R., Reid W.R.,
RA   Rinkevich F.D., Robertson H.M., Sackton T.B., Sattelle D.B.,
RA   Thibaud-Nissen F., Tomlinson C., van de Zande L., Walden K.K.,
RA   Wilson R.K., Liu N.;
RT   "Genome of the house fly, Musca domestica L., a global vector of
RT   diseases with adaptations to a septic environment.";
RL   Genome Biol. 15:466-466(2014).
RN   [2] {ECO:0000313|VectorBase:MDOA010060-PH}
RP   IDENTIFICATION.
RC   STRAIN=Aabys {ECO:0000313|VectorBase:MDOA010060-PH};
RG   VectorBase;
RL   Submitted (NOV-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   VectorBase; MDOA010060-RH; MDOA010060-PH; MDOA010060.
DR   Proteomes; UP000095301; Whole Genome Shotgun Assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 2.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000095301};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000095301};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     52     75       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    138    162       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       18    167       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      174    347       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION      379    399       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      439    490       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    439    481       Polar. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   490 AA;  55659 MW;  32BD116F86780928 CRC64;
     MYRQTRFSSR RIRKRVIFKH GDCNVVQGNV AKRRRRYLQD IFTTLVDAQW RWTLLVFACS
     FLISWAFFGL IWWTIAYAHG DLEWIDNRDN RPELIQNMTH TMCVTEVRSF ISAFLYSIET
     QHTIGYGNRF VTEECPEAIF TICLQCITGV FIQAFMVGIV FAKLSRPKKR AQTLLFSRNA
     VICHRDGVPC LMFRVGDMRK SHIIEAHVRA QLIRKKVTKE GEVLPFYQQE LKVGADGGED
     RLMFIWPTTI VHKIDRHSPL YMLSASDMLK ERFEVVCMLE GVIESTGMTT QARSSYLPSE
     ILWGHRFVNV VSFRKETGEY EVDYTLFNNT YDVDTPLCSS KELDDLKEEY SKNHKAGLDR
     ALSAGLLKHI SSVASVDHMD PASDESLDSG RLHTRSNSIP NGALATELEP LNNNTPSFTV
     GGSSILPSIT TNFQSINEKI NSTNGSSTHN NNNNNSGSNI NHSSSNTSLK AKSSRRLSIK
     QDQLPVDSLC
//
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