ID A0A1I8MZY5_MUSDO Unreviewed; 324 AA.
AC A0A1I8MZY5;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Cyclin-H {ECO:0000256|ARBA:ARBA00019496};
GN Name=101891621 {ECO:0000313|EnsemblMetazoa:MDOA010108-PA};
GN Synonyms=LOC101891621 {ECO:0000313|RefSeq:XP_005176814.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA010108-PA};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA010108-PA}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA010108-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005176814.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_005176814.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Regulates CDK7, the catalytic subunit of the CDK-activating
CC kinase (CAK) enzymatic complex. CAK activates the cyclin-associated
CC kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK
CC complexed to the core-TFIIH basal transcription factor activates RNA
CC polymerase II by serine phosphorylation of the repetitive C-terminal
CC domain (CTD) of its large subunit (POLR2A), allowing its escape from
CC the promoter and elongation of the transcripts. Involved in cell cycle
CC control and in RNA transcription by RNA polymerase II. Its expression
CC and activity are constant throughout the cell cycle.
CC {ECO:0000256|ARBA:ARBA00025343}.
CC -!- SUBUNIT: Associates primarily with CDK7 and MAT1 to form the CAK
CC complex. CAK can further associate with the core-TFIIH to form the
CC TFIIH basal transcription factor. {ECO:0000256|ARBA:ARBA00026042}.
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin C subfamily.
CC {ECO:0000256|ARBA:ARBA00008638}.
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DR RefSeq; XP_005176814.1; XM_005176757.3.
DR STRING; 7370.A0A1I8MZY5; -.
DR EnsemblMetazoa; MDOA010108-RA; MDOA010108-PA; MDOA010108.
DR GeneID; 101891621; -.
DR KEGG; mde:101891621; -.
DR VEuPathDB; VectorBase:MDOA010108; -.
DR eggNOG; KOG2496; Eukaryota.
DR OrthoDB; 5481790at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0070985; C:transcription factor TFIIK complex; IEA:InterPro.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd20524; CYCLIN_CCNH_rpt1; 1.
DR CDD; cd20525; CYCLIN_CCNH_rpt2; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 2.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR043198; Cyclin/Ssn8.
DR InterPro; IPR031658; Cyclin_C_2.
DR InterPro; IPR006671; Cyclin_N.
DR InterPro; IPR027081; CyclinH/Ccl1.
DR NCBIfam; TIGR00569; ccl1; 1.
DR PANTHER; PTHR10026; CYCLIN; 1.
DR PANTHER; PTHR10026:SF8; CYCLIN-H; 1.
DR Pfam; PF16899; Cyclin_C_2; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
PE 3: Inferred from homology;
KW Cyclin {ECO:0000256|RuleBase:RU000383};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905}.
FT DOMAIN 62..149
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
SQ SEQUENCE 324 AA; 38154 MW; C2EF061F623EE988 CRC64;
MYPLSSQKKY WTFSSPEQLN DLRLKRNQKF IETHGSHMDD QQRMEFFLDA NEEHLLLKQY
EIYLNDFCRR FEPMMPKCVV GTAIHYFKRF FLHNSPMDYH PKEILATCVY LACKVEEFNV
SIGQFVSNIK GDRNKAMDII LSNELLLMQH LNYYLTIHNP YRPVEGFLID IKTRSSMVNP
ERLRPHIDSF IEKTFFTDAC LLYAPSQIAL AAVLHAAGRE QENLDSYVTD NLLNGAREKL
PALIEAIRKI RIMVKQYEVP LRDRVKLIEK KLEKCRNQEN NPDSEIYKER MRKMYCDDDL
EVAEDNSYYI ADSSADMSAL NMSQ
//
