ID A0A1I8N0A6_MUSDO Unreviewed; 1133 AA.
AC A0A1I8N0A6;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=GTPase-activating protein isoform X1 {ECO:0000313|RefSeq:XP_011292425.1, ECO:0000313|RefSeq:XP_011292426.1};
GN Name=101893530 {ECO:0000313|EnsemblMetazoa:MDOA010226-PC};
GN Synonyms=LOC101893530 {ECO:0000313|RefSeq:XP_011292425.1,
GN ECO:0000313|RefSeq:XP_011292426.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA010226-PC};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA010226-PC}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA010226-PC};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_011292425.1, ECO:0000313|RefSeq:XP_011292426.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_011292425.1,
RC ECO:0000313|RefSeq:XP_011292426.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_011292425.1; XM_011294123.2.
DR RefSeq; XP_011292426.1; XM_011294124.2.
DR STRING; 7370.A0A1I8N0A6; -.
DR EnsemblMetazoa; MDOA010226-RB; MDOA010226-PB; MDOA010226.
DR EnsemblMetazoa; MDOA010226-RC; MDOA010226-PC; MDOA010226.
DR VEuPathDB; VectorBase:MDOA010226; -.
DR OrthoDB; 24454at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd08401; C2A_RasA2_RasA3; 1.
DR CDD; cd04010; C2B_RasA3; 1.
DR CDD; cd01244; PH_GAP1-like; 1.
DR CDD; cd05128; RasGAP_GAP1_like; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001562; Znf_Btk_motif.
DR PANTHER; PTHR10194:SF60; GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00779; BTK; 1.
DR Pfam; PF00168; C2; 3.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00107; BTK; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS51113; ZF_BTK; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00432}.
FT DOMAIN 9..133
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 230..394
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 479..673
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 742..843
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1050..1111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1050..1084
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1092..1111
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1133 AA; 129096 MW; 9D019029F633D8B4 CRC64;
MHLKKKHPIS YGSNMADNTR EVRIEEQLKV KIGEAKNLSS RNAANTSCST QGTRDVYCTI
ALDQEEICRT PTIERTLSPF FGEEYQFKIP RRFRYLSVYV WDRDRHMKQD KPIGKIAIKR
EELHMYNHKD HWFSLRPVDS DSEVQGMAHI EVQFEESPAH INEQRINMLR PSDYDRNNSE
IIEEFVQQHQ SLQNDYKENS ELSNIQRNNT NKHRSTGGTG GGSGSIFNLH HHQHQQSIED
GTNWKNTAAN GKHSRVTIRI PECTDLPKKN GTCDPYVMCT ATYSNKRQIS KRTKLRKKTV
NPEFDESMSF DLSIDGESSS SAKSAHFDSS SGGGTINSNK AYTIYPVGGA DLCEITVSVW
HDASGMSDKV FLGEVKLPMR NKQQQASIQP SAWYYLQPRS LSSAVRSVNP STRSCATPPG
TRLSGDSTIG SLRLKILYTA DHVFPLATYD DLMNLLLESV DQRPITLSSV FILGELVSCK
TDVSQPLVRL FTHTGRIAPI IKALADHEIS NLTDPTTIFR GNTLVSKMMD EAMRLSGLHY
LHQTLRPVLA QILAEKKPCE IDPSKVKDRS AVDTNLHHLQ DYVEKVFDAI TKSAVRCPKV
LCQIFHDLRE CAGRHFPHNR EVRYSVVSGF IFLRFFAPAI LGPKLFDLTT EPLDCQTNRT
LTLISKTIQS LGNLVSSRSS QQPCKEEYTG QLYKKFCTEK HVEAVKAFLE NISTPSIDEN
GSNHESGSLF PIGENSLEPV LLKEGEGMMT KYPQCRKRFG RRPFKQRYFR LTTQSLCYAK
SKGKQPICDI PLSEIERVEQ LNEKSFKMQN CFKIVRKDRS LIVQTTNCVE EREWIDLLHK
ICLTNSIRSQ YFHPSAFVNG VYSCCDRSDE NAPGCKNVSA EAMDYFQMDL ITALDPALDL
QRIHTLIMSH MTQLEAFLDQ VGVFHQLQQQ HNPLVATAMT LQQQSPHLYS KFKATIMQLR
EVAYVIDKDH RNYKQGISRE LKYGSRQAPI GDDNYLQMMR TAGHMDLQAQ QHQHQQQILP
QMQLVMAYPY HQQHSQQQSN MNAYFMHNLQ SSSSQQRQQQ LSLYQQQQQQ QQQQQQQNNQ
HSVRAAAMVH HHSSATPSSS NSSTTSSVAP TITPTSSIYL REKLSVERYA NKC
//
