ID A0A1I8N0W5_MUSDO Unreviewed; 674 AA.
AC A0A1I8N0W5;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=glutamine--fructose-6-phosphate transaminase (isomerizing) {ECO:0000256|ARBA:ARBA00012916};
DE EC=2.6.1.16 {ECO:0000256|ARBA:ARBA00012916};
GN Name=101889985 {ECO:0000313|EnsemblMetazoa:MDOA010388-PH};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA010388-PH};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA010388-PH}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA010388-PH};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-
CC phosphate + L-glutamate; Xref=Rhea:RHEA:13237, ChEBI:CHEBI:29985,
CC ChEBI:CHEBI:58359, ChEBI:CHEBI:58725, ChEBI:CHEBI:61527; EC=2.6.1.16;
CC Evidence={ECO:0000256|ARBA:ARBA00001031};
CC -!- PATHWAY: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-
CC glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-
CC fructose 6-phosphate: step 1/1. {ECO:0000256|ARBA:ARBA00004775}.
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DR AlphaFoldDB; A0A1I8N0W5; -.
DR EnsemblMetazoa; MDOA010388-RH; MDOA010388-PH; MDOA010388.
DR VEuPathDB; VectorBase:MDOA010388; -.
DR UniPathway; UPA00113; UER00528.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR GO; GO:0004360; F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity; IEA:UniProtKB-EC.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006048; P:UDP-N-acetylglucosamine biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00714; GFAT; 1.
DR CDD; cd05008; SIS_GlmS_GlmD_1; 1.
DR CDD; cd05009; SIS_GlmS_GlmD_2; 1.
DR Gene3D; 3.60.20.10; Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1; 1.
DR InterPro; IPR017932; GATase_2_dom.
DR InterPro; IPR005855; GFAT.
DR InterPro; IPR047084; GFAT_N.
DR InterPro; IPR035466; GlmS/AgaS_SIS.
DR InterPro; IPR035490; GlmS/FrlB_SIS.
DR InterPro; IPR029055; Ntn_hydrolases_N.
DR InterPro; IPR001347; SIS_dom.
DR InterPro; IPR046348; SIS_dom_sf.
DR NCBIfam; TIGR01135; glmS; 1.
DR PANTHER; PTHR10937; GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING; 1.
DR PANTHER; PTHR10937:SF0; GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING); 1.
DR Pfam; PF13522; GATase_6; 1.
DR Pfam; PF01380; SIS; 2.
DR SUPFAM; SSF56235; N-terminal nucleophile aminohydrolases (Ntn hydrolases); 1.
DR SUPFAM; SSF53697; SIS domain; 1.
DR PROSITE; PS51278; GATASE_TYPE_2; 1.
DR PROSITE; PS51464; SIS; 2.
PE 4: Predicted;
KW Aminotransferase {ECO:0000256|ARBA:ARBA00022576};
KW Glutamine amidotransferase {ECO:0000256|ARBA:ARBA00022962};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
SQ SEQUENCE 674 AA; 75722 MW; 7925CFD670295971 CRC64;
MCGIFAYLNY MTPKSRAEVL ELLVNGLKRL EYRGYDSTGV AIDGPNTKDI VMIKSVGKVK
VLEDAIAKSC TGKEFEEPIT THVGISHTRW ATHGVPCERN SHPQRSDFDN SFVVVHNGII
TNYKDVKTYL ETRGYEFESD TDTEVIAKLV HHLWKKHPGY SFRELVEQAI QQLEGAFAIA
LKSKYFPGEC VASRRGSPLL VGIKTKTRLA TDHIPILYGK DDKKQQTEQV LPRSESTSEF
LPMEQKEVEY FFASDASAVI EHTNRVIYLE DDDVAAVRDG GLSIHRLKKS TDDPHAREIT
TLKMEIQQIM KGNYDYFMLK EIFEQPESVV NTMRGRVRFD SNTIVLGGIK DYIPEIKRCR
RLMLIGCGTS YHSAVATRQL LEELTELPVM IELASDFLDR NTPIFRDDVC FFISQSGETA
DTLMALRYCK QRGALIVGIT NTVGSSICRE SHCGVHINAG PEIGVASTKA YTSQFISLVM
FGLVMSEDRL SLQQRRLEII QGLSKLADQI REVLKLDSKV QELAKDLYQH KSLLIMGRGY
NFATCMEGAL KVKELTYMHS EGIMAGELKH GPLALVDDSM PVLMIVLRDP VYVKCMNALQ
QVTSRKGCPI IICEEGDEET KAFCSRSLEI PRTVDCLQGI LTVIPMQLLS YHIAVLRGCD
VDCPRNLAKS VTVE
//
