ID A0A1I8N209_MUSDO Unreviewed; 1207 AA.
AC A0A1I8N209;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=101889225 {ECO:0000313|EnsemblMetazoa:MDOA010723-PB};
GN Synonyms=LOC101889225 {ECO:0000313|RefSeq:XP_005178386.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA010723-PB};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA010723-PB}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA010723-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005178386.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_005178386.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family.
CC {ECO:0000256|ARBA:ARBA00007025}.
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DR RefSeq; XP_005178386.1; XM_005178329.3.
DR EnsemblMetazoa; MDOA010723-RB; MDOA010723-PB; MDOA010723.
DR GeneID; 101889225; -.
DR VEuPathDB; VectorBase:MDOA010723; -.
DR OrthoDB; 3269924at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006807; P:nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR GO; GO:0044238; P:primary metabolic process; IEA:UniProt.
DR CDD; cd11726; ADDz_ATRX; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR025766; ADD.
DR InterPro; IPR041430; ADD_ATRX.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46357; TRANSCRIPTIONAL REGULATOR ATRX; 1.
DR PANTHER; PTHR46357:SF1; TRANSCRIPTIONAL REGULATOR ATRX; 1.
DR Pfam; PF17981; ADD_ATRX; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS51533; ADD; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 51..189
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51533"
FT REGION 227..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 284..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 634..667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 786..812
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 900..1054
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1095..1117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1130..1207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 284..334
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 646..667
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 900..945
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 955..1054
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1142..1189
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1207 AA; 132945 MW; 4787693A3605C41B CRC64;
MSEAMAAIAG GSSSLEMASP SNVADGSKAV SYEFHSSISE EEKRFYLKAY PTVDIVRDRK
VHCTVCKTHI GTAPVQETGI KMHPILRVTH CLKCHDFYNS GEFSKGEDGS ELYCRWCGQG
GEVYCCSSCP YVFCKSCIVK NLSRGVVADI EQNENWNCFS CAPKILWPLR AQHWALMNYI
EQQKKEAYAM NLSEQELDQF LRRDRSKCCR LAKAKCGNMS DSMESLDSVL SKRSQGSSGS
AKKAAKHGTT PSPQQPNAKR PKNNDEVVCT PDLLSMLEPD CQITVSQKNN GGTPQRPLST
QSGPSPRIIS IQQSPNSFGG QSVSSSTPKT SAPPPLLLRN TAIKLRPATQ PPIVRRTVIG
PRAPAPGGNT APVYHTINGY RIDLNSAAQQ ETFRLPNGKL IQVKRQGPPP GSNQAPTTNW
QQMSQQQQQQ RVVPQTIASR PVQITAHPYP GPNAIQTPGQ PQVVRYHNNV IGSTTINAIA
HNGTPLQAIN GQIPAQAQVV PNAPQMAPGQ PIRPVMVRHI FPDTPIGQAR TQLQEQVFNA
MEICTHLTNK VQTLTNSNAY KQAKNYLEVK ELYIHLSYLL TYAIGRFKGL QDKCLADMRH
LGFGNDADCL ENGQLAADKQ ASDDEDNEIE IVEPKTDLIT LDSDDDEPTP TPTATPTAAS
KPTQTQPLIK IQKSIPATPP TSTTIAQSRV VITPLLLNQQ KTPSASNNIM SARGTYVPPT
AAKITPIKVG HSPAPMPLPP LVPVTTATTP TPTPPKGVPS EEEDNMDLMS MAQSFLASML
EVDVNDGSSL SSCDSTPHKK KQPRKKLTSK PNPTLIKQKA IMELERLEEM KRNDQKLKMK
CKVELSRAED EYPFVKNLLE AKKKNEEDMK VKSSPDGTTM MVNTGQETVE VHLVIEDDLL
NSSLEEKSSK EEENGNREKT KNEEHKRKEI TETNLEDEDG NGKKNTAMEV FEISDDVLAD
AKENSSESLR QKEAKTTIEE EKSIDEKAIE SSSKEPKENS EEFSVTETIE KLVKSKESVV
ETSEESKMEV DASPEEQSQR CEEETPAKIA ADSDDVDVYK EIAKVLQRKS SVEEQQQETE
DTVQEKITAA VANTMTTTEQ NAENNDNLTQ GDTEKDSNIE KCIDSAIEEV TDDILQKPST
PLVDETMESD DIQTDINQTP TTTREAEISC IDATSKEQNT AYPSVTEETQ PVTEEKEQQK
STSNGNV
//
