ID A0A1I8N323_MUSDO Unreviewed; 475 AA.
AC A0A1I8N323;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=TOM1-like protein 2 isoform X5 {ECO:0000313|RefSeq:XP_011293800.1};
GN Name=101893934 {ECO:0000313|EnsemblMetazoa:MDOA011029-PB};
GN Synonyms=LOC101893934 {ECO:0000313|RefSeq:XP_011293800.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA011029-PB};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA011029-PB}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA011029-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_011293800.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_011293800.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TOM1 family.
CC {ECO:0000256|ARBA:ARBA00007708}.
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DR RefSeq; XP_011293800.1; XM_011295498.2.
DR EnsemblMetazoa; MDOA011029-RB; MDOA011029-PB; MDOA011029.
DR GeneID; 101893934; -.
DR KEGG; mde:101893934; -.
DR VEuPathDB; VectorBase:MDOA011029; -.
DR OrthoDB; 609735at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd14233; GAT_TOM1_like; 1.
DR CDD; cd03565; VHS_Tom1_like; 1.
DR Gene3D; 1.20.58.160; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR004152; GAT_dom.
DR InterPro; IPR038425; GAT_sf.
DR InterPro; IPR014645; TOM1.
DR InterPro; IPR002014; VHS_dom.
DR PANTHER; PTHR13856:SF137; GH05942P; 1.
DR PANTHER; PTHR13856; VHS DOMAIN CONTAINING PROTEIN FAMILY; 1.
DR Pfam; PF03127; GAT; 1.
DR Pfam; PF00790; VHS; 1.
DR PIRSF; PIRSF036948; TOM1; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF89009; GAT-like domain; 1.
DR PROSITE; PS50909; GAT; 1.
DR PROSITE; PS50179; VHS; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 23..156
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT DOMAIN 205..293
FT /note="GAT"
FT /evidence="ECO:0000259|PROSITE:PS50909"
FT REGION 172..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 443..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..200
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 443..463
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 475 AA; 52249 MW; 86A81450D8BF558E CRC64;
MASFLNLGTN PFSTPVGQRI EQATDGSMAT ENWALNMEIC DMINESSDTA RDAMKAIRKR
LQQNAGKNNQ VIMYTLTVLE TCVKNCGKAF HVLVAQKDFI QELVKLIGPK NDPPLIVQEK
VLNLIQVWAD AFKNQPDLNG VTQMYIELKN KGIEFPQTDI ENMAPIYTPQ RSVPEPPPPQ
AVTQQAVSPQ HSGMPNTASN QLTPEQIAKL HSELEIVSMN ISILGEMLTE LKPGQEDPDD
YQLLNDLTAT CKEMQSRIVD LIGRVTDDEL TAELLRINDE LNNMFLRHQR YEKNRATTTN
MTSPSAVLGA AMGVPTTNVP ASNLPASNEP KLLDFPDANK DDMLNNFNRL GLNSSTKPSN
KDADEFDMLA QSRTNGNNKS DLLKDIPTLD ATAGSVGSPF KRAGGNGLPV VSKKVIEGLE
ETVTSSEFDK FLEERAAAAE NLPTINATNN LDNSAQQTTN QQAKTKKPEE DLLLL
//
