ID A0A1I8N3F6_MUSDO Unreviewed; 2471 AA.
AC A0A1I8N3F6;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:MDOA011113-PB};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA011113-PB};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA011113-PB}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA011113-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EnsemblMetazoa; MDOA011113-RB; MDOA011113-PB; MDOA011113.
DR VEuPathDB; VectorBase:MDOA011113; -.
DR eggNOG; KOG4292; Eukaryota.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00041; CUB; 14.
DR CDD; cd22201; cubilin_NTD; 1.
DR CDD; cd00054; EGF_CA; 5.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 14.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR46908:SF4; CUBILIN HOMOLOG; 1.
DR PANTHER; PTHR46908; CUBILIN-LIKE PROTEIN; 1.
DR Pfam; PF00431; CUB; 14.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF07645; EGF_CA; 2.
DR SMART; SM00042; CUB; 14.
DR SMART; SM00181; EGF; 7.
DR SMART; SM00179; EGF_CA; 6.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 15.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS01180; CUB; 15.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DISULFID 6..15
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 230..239
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 268..277
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 284..311
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT DISULFID 801..828
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
SQ SEQUENCE 2471 AA; 277760 MW; 6C59E4A76A998F32 CRC64;
MLRCTCAKGF SGTHCRLSNT QCQLFQSAEL CGHGTCIPAN NQHGYTCLCD QGWSTNTTLA
TNSTASLVCD VDIDECEETK NPCHNGCINL PGSFKCGPCP AGYTGDGMNC YDIDECDSNN
GGCSSSPLVR CINTEGSYVC GKCPPGWIGD GHTCDLAPSN SCDAEKICHP QAKCEYISNI
ATCTCAHGMF GHGFGPEGCH TNPMTDSCEN HICQNNGTCL AMGRSTRCMC PLGYSGALCE
TKDACHPNPC ENEGTCKALG DESYKCSCPR GTTGKRCEVL RSVCSSIQRK PSGELSYPAD
GATEYAPLER CAWIIRTLPN RILRLNFLTF DVEPDPECSR DWLQIHDGNS LAAQLIGRFC
GNELPLNGTI LSSHNVLFFW FRSDNATQRS GFHMNWTSQV YVCGVTLEVA IGETGVIRSP
GYPGKVAAHR DCQWKFTAPM GYRFHLRIYD IEMGNSPNCT GDSLKPKEVQ TEVIVIVLIL
DKIGASNDNQ PQILSKNGGL ALQSVRDKNI HLRLNQGSSL IFNDTDILEE IHQLYTYEDK
STTFSRKSVS DEVHKLREGI SRLVQRFSHF ENSTRNTLKM RVMRQFLRRL NRLTMRLSVI
EENVSQNECT DGPCKNGGTC YDLYKGYHCE CPDGWQIYDA DLISKEYCQI TTPQTLRTSS
NELKLKLHTD GYGSDTSFQL HFEVESSIPH CGGVFTAASG IILGPSEPSI CLYSIKQPLN
MQVKITFAEL NLSDEENCNL HSIEIFDGKT DEDSRLLIAC GGTVVPPPVV SSGNSVLIRY
MNKFPTKGLE SPFKIKYTQD CEFRYFGPDN GIITTPNYPN PFTEHITCTY HIYGPAETMV
LANFTDISLP PTGGLDNAAN DAVAMQNDTL TYFEVHLSDT NRQCFYKAAS PMELYSELNK
MTIVFHATSN AARARGLRIE YSFEETECGG VYTEPSGIFM KGLHDGICKY IFEASEDKHI
HLSFTHYTLM DTKLSTEIYG RMPGEKNVLL KNISSSNQSV NETFHFNVIT VIPDLSVFLF
GGTYEFVNNT EACGGNYVAL YGVIKSPNWP RLYSAKLDCV WTISAPMGYK IELRVQNFTL
EPECTGDILE IRNGKFPDSP LIGRYCGQEI PSRIPSFGNS LYLRFTTDST VEAPGFHIIW
EQMETGCGGK LTSHKGSIHS PMVATFEEIG VKCDWLIHVA EGSGIQLKLT YLTNPEDFCR
RNNLHIYQGS TTSKPFDNQP CLRPMEKNEE LFFSSDNQML VVYTAFNVGE DYTDFVIDYE
TYCKTVLDHV QGIIESPNFP EPYPELLDCR WDIKAGLNNH IKLAFSHFSL ETSDLECEND
YVEVWDMKDE DILKKYHLCS RPNDVITSEG NQLRVRLVTD YSNNKNGFRA EYTRVGCGEV
LTNEFGTIAS PNYPFSGGLE CEWYIEVPAG KQIVFTVTEC QGDYEHVNCS LDSITVKESK
TSPYTLMHYC ISQQPITNIY SPMNRLYVQY QAGPSRGRKF FKAMYHTRDA TCGGVLRVTS
GWLYSPSYPR NTTEELSCKW DISVADANVI YLTIKELEFN QSENCEDNYL KIAEESSERT
VTNVSKICSL DRGLFMLNSS RVTIEYKNQK SLYGSRFMLL YRSMCGGKLE MDSGLIVAAS
NEDCFWTLSV AKGNSISLNI LELDCFCSKT ENGTKSCGTR GLGLSTNNEN PQTYTDLICE
KFQSHMIFES TQLYIYTNGI NFRATYSTTQ HSCGGTITAA RGILTSPNYP LPYAGNIECI
WTITAKLGNT IQIEFDDLDM AASEHCNEDF LEIRSWLGSK ALAIYCGNAV PEEILKSKDS
MWLKFRSSEG SSGKGFKLKW SYAHLTEYVN ETRGLIESPP TSLLRNEDET FAWRILVPRQ
QFVALYFKTY LDGLKLYDGY DSTALPIEIS DAPWRFVSSS NVLYFETDIE NPNYFQISWN
TTNVTVVDSN VTTSKCHVDR LIKPHASVMI YSPNYPSKYD NNLACDWIFK PFLSTQHVVC
EVYEVKLENV SACTSDYLKI STSSDLVQWH EEAKLCDSPD KTYTPYRIYN GTPNLKLDFV
TDVSIKGKGF AARIITKCGS NLTQSVGFIE GEKLLYETDC HWRIRVRPGK RILLQFDFAP
AIVKNPPECL DYVLIYDGID RHAPLLPPGK LCIPQNVSQI QMNSSSNYLA IQYKLALPRP
IMSRRWNLTY REYSTCNEEY RLIPEANSIN ITSPNYPNVP PPHTECEWRV MAPRGELIDI
KFFDDFHMNT KYCDREYVEL FDGATALAKS LGKYCRTPPP LKTTQNLLYI HYLTDVSEPR
AGFKVQLSIG KCGGTFTASS EIITSPGYPQ PGAYPAHSEC DYVISQPADT RIRLILLNIN
LPFNHNFPKS KDYLEIIPII PAEVNETIPS VFVFGNATRG TQIDLNVNKA IIRFHTSARA
TLYHGFQIKF NRFSGQCHQE MEGVSGPITL SFPRRSFYSS YCRWKMTVPK GLRVRLEFLN
MGDFEVQNES R
//
