ID A0A1I8N4L1_MUSDO Unreviewed; 601 AA.
AC A0A1I8N4L1;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Autophagy-related protein 16 isoform X2 {ECO:0000313|RefSeq:XP_005190988.1};
GN Name=101901279 {ECO:0000313|EnsemblMetazoa:MDOA011478-PB};
GN Synonyms=LOC101901279 {ECO:0000313|RefSeq:XP_005190988.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA011478-PB};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA011478-PB}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA011478-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005190988.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_005190988.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WD repeat ATG16 family.
CC {ECO:0000256|ARBA:ARBA00009271}.
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DR RefSeq; XP_005190988.1; XM_005190931.3.
DR EnsemblMetazoa; MDOA011478-RB; MDOA011478-PB; MDOA011478.
DR VEuPathDB; VectorBase:MDOA011478; -.
DR OrthoDB; 458014at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0000045; P:autophagosome assembly; IEA:InterPro.
DR CDD; cd22887; Atg16_CCD; 1.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR045160; ATG16.
DR InterPro; IPR013923; Autophagy-rel_prot_16_dom.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19878; AUTOPHAGY PROTEIN 16-LIKE; 1.
DR PANTHER; PTHR19878:SF8; AUTOPHAGY-RELATED 16, ISOFORM F; 1.
DR Pfam; PF08614; ATG16; 1.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 12..203
FT /note="Autophagy-related protein 16"
FT /evidence="ECO:0000259|Pfam:PF08614"
FT REPEAT 303..344
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 347..388
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 389..430
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 447..472
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 220..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 79..197
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 250..264
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 601 AA; 66768 MW; 719598DDBE891C19 CRC64;
MAQEDQEYRQ TIINRLRERN RRDVLPFKEI IQQNNRLLDS VAQLKADNLK ISVENEQLRT
AISTGGGGGK DSTAAQLAIA ALEKKLLAQQ EELTALHKRK GENSQLIVDL NLKMEKQQQI
IASKEQSLAE QKNTNASLKA EVQMLKSSLE ELKNLNTTLR DEYTALQLAF SALEDKLRNV
QDENRRLLDR LMHYKAKDAD KLNEENESFI RKRSDKLKRE LEDAVREPNS SFTHHRNSSG
SSIHGGAGGD AYDDSDRDTL SGDHNIETGC DAEMYGSPQD PFHIGGMGSY MKSANPTNIY
MKFEAHETES HAVRWSPIER VIATGGADRK VKLWDVGKGS SEPRSVLGGS SAGINSVDFD
STGTYIIGTS NDYGARVWTV GDNRLRHTLT GHSGKVMAAK YIQEPVKVVT GSHDRTLKIW
DLRSIACIET KFAGSSCNDL VTTDSLGSTI ISGHYDKKIR FWDIRTEKQA DDILMNAKIT
SLDLSKDCNY LICSVRDDTI KLLDLRKNQV ISTFSNEHFK LSCDWARASF NMNATKIACG
SSDGVIYIWN VMGNLECELK GHASGSGLFH SSAVNAVSWS PNFNALASVG KGKKCLIYTE
S
//
