ID A0A1I8N513_MUSDO Unreviewed; 1587 AA.
AC A0A1I8N513;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN Name=101888424 {ECO:0000313|EnsemblMetazoa:MDOA011615-PB};
GN Synonyms=LOC101888424 {ECO:0000313|RefSeq:XP_005182923.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA011615-PB};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA011615-PB}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA011615-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005182923.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_005182923.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC -!- SIMILARITY: Belongs to the SARM1 family.
CC {ECO:0000256|ARBA:ARBA00008291}.
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DR RefSeq; XP_005182923.1; XM_005182866.3.
DR EnsemblMetazoa; MDOA011615-RB; MDOA011615-PB; MDOA011615.
DR VEuPathDB; VectorBase:MDOA011615; -.
DR OrthoDB; 5475697at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0050135; F:NAD(P)+ nucleosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0061809; F:NAD+ nucleotidase, cyclic ADP-ribose generating; IEA:UniProtKB-EC.
DR GO; GO:0035591; F:signaling adaptor activity; IEA:InterPro.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0019677; P:NAD catabolic process; IEA:UniProt.
DR GO; GO:0034128; P:negative regulation of MyD88-independent toll-like receptor signaling pathway; IEA:InterPro.
DR GO; GO:0048678; P:response to axon injury; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd09501; SAM_SARM1-like_repeat1; 1.
DR CDD; cd09502; SAM_SARM1-like_repeat2; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR039184; SARM1.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR22998:SF1; NAD(+) HYDROLASE SARM1; 1.
DR PANTHER; PTHR22998; SARM1; 1.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF07647; SAM_2; 1.
DR Pfam; PF13676; TIR_2; 1.
DR SMART; SM00454; SAM; 2.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunity {ECO:0000256|ARBA:ARBA00022588};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 857..921
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 1004..1148
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 35..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 87..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 229..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1188..1283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1300..1326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1413..1570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..70
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1188..1219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1236..1253
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1261..1278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1300..1322
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1416..1446
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1454..1482
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1537..1570
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1587 AA; 170588 MW; D578CEFA0BCF22E3 CRC64;
MVVTSTRSHL VTSQPVANSA PTTVYRSKLI YPRSSGTTLH QHHHHQQSHS HHGHGNQMSD
FSDSSQSGVI SPASSFIENF HKKNGTVPGG ASSTSSSVTT SPSISIPSTI GGTTSPSING
GGGGNQIAIS GGGGGSTSRQ INASSSSSVK ETSSTSSSQQ VVNSSSSSST TTRVEKKSRL
HHITSSSSSS SSSTSTEMKA AALKRDMSEF KNSMSEINDL ALGRNASPAL SGSTGTLSHH
QPPSINDLNS LNSADAINKL KKKIRSSLEN IVDGNTEPSI TFPDDSDDND MNLNMDLVKA
SNQLSTNGLS GSKGTLVDTV KFEEKRTKTE SKTKVITDGF SSEQATSNLA ESKRLQTGDI
DYQQAKAAAA SRNRMEMDGV KTEENAAVIH EALSLRTGDI TQQASNNVAA ASIKVQSDTF
SADKKAISQS QQSQTMTSNG IISQEKHMSS AAQANYTMTS KGVSSSGGST MISSSSQMST
TNGSFFKLAD FKIDDLMSLS ANSGQREIEQ AISKYSNMLT NCVSTLQEKK ADSEATLFLD
KINEVIRRAW AVPTHGHELG YSLCNSLRSS GGLDLLMRNC VQSDMRIKFS SAKLLEQCLT
TENRTHVVEN GLDKVVNVAC VCTKNQSTEH SRVGTGILEH LFKHSEGTCS DVIKLGGLDA
VLFECRTSDV ETLRHCASAL ANLSLYGGAE NQEAMILRKV PMWLFPLAFH NDDNIKYYAC
LAIAVLVANK EIEAEVLKSG CLDLVEPFVT SHDPSEFAKS NLAHAHGQSK HWLQRLVPVL
SSNREEARSL AAFHFCMEAG IKREQGNTEI FREIGAIEAL KTVASCPNAI ASKFAAQALR
LIGETVPHKL SQQVPLWSVE DVQEWVKQIG FGQCVKQFEE SQVDGDLLLK LTDKNLRDDI
GIMNGILLKR FERELQNLKR MADYSSKDTA KLHQFLAEIG PEYCTYTYSM LNAGIDKNSL
PHLNEDMLIQ ECNITNSIHR LRILNAVKSL ENTLSSASED SMAKTLDVFV SYRRSNGSQL
ASLLKVHLQL RGFSVFIDVE RLEAGKFDNG LLNSIRQAKN FVLVLTPNAL ERCVDDNECK
DWVHREIVAA LNSNCNIIPI IDNQFSWPES ERLPEDMRSV CHFNGVTWIH DYQDACIDKL
ERFMRGEKNI DRIAAMTPGT PSSTVTYQRM HSNDSDYSVA GSNAGGSNCG GSGGNSGSSV
NGGGQAASHQ ANRYRQSASP ARQRLGPGGG GGSMISSTGK LGSTGSQLSV FGRGSKRNMF
PPYRTQPTSA QKPLVMGGSM QNVSPLAYKP PRRSSAVGIC NDSGDSKPPA TNYRSHSVDG
LLDSSESSER KIAEAAAIVS AGSMALTNAS STSTLQPNED YSVSTDDLVE NDVSANVSRR
DKSAHLPPIN PQHRKSRSLD HFLDEQTLAA IVVPPSPTDG TQSMQNLATP QTPEPMRSTN
VINGAIHSLP MRSASVRDSK SLTPDRVTAL RQSPSNRQSP EGISSAEDEH EDSQSVKSCQ
STKSSPAPPV PVAAKTNAAN KSQTRAAAHV HRGNGASRVP KTTSSSSLGS TPTKSGTTPT
AAAAAGDNNK TIFNRTIKKV RSLIKKP
//
