UniProt: A0A1I8N5P9

Database: UniProt
Entry: A0A1I8N5P9_MUSDO

LinkDB:  A0A1I8N5P9_MUSDO 
Original site:  A0A1I8N5P9_MUSDO

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Ontology (6)   
   GO (6)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (8)   
   InterPro (6)   
   Pfam (2)   
All databases (18)   

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ID   A0A1I8N5P9_MUSDO        Unreviewed;       393 AA.
AC   A0A1I8N5P9;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   RecName: Full=Mevalonate kinase {ECO:0000256|RuleBase:RU363087};
DE            Short=MK {ECO:0000256|RuleBase:RU363087};
DE            EC=2.7.1.36 {ECO:0000256|RuleBase:RU363087};
GN   Name=101901472 {ECO:0000313|EnsemblMetazoa:MDOA011818-PA};
GN   Synonyms=LOC101901472 {ECO:0000313|RefSeq:XP_005183768.1};
OS   Musca domestica (House fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC   Muscidae; Musca.
OX   NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA011818-PA};
RN   [1] {ECO:0000313|EnsemblMetazoa:MDOA011818-PA}
RP   IDENTIFICATION.
RC   STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA011818-PA};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_005183768.1}
RP   IDENTIFICATION.
RC   STRAIN=Aabys {ECO:0000313|RefSeq:XP_005183768.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+);
CC         Xref=Rhea:RHEA:17065, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:36464, ChEBI:CHEBI:58146, ChEBI:CHEBI:456216;
CC         EC=2.7.1.36; Evidence={ECO:0000256|RuleBase:RU363087};
CC   -!- PATHWAY: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis
CC       via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate:
CC       step 1/3. {ECO:0000256|ARBA:ARBA00029438,
CC       ECO:0000256|RuleBase:RU363087}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU363087}.
CC   -!- SIMILARITY: Belongs to the GHMP kinase family. Mevalonate kinase
CC       subfamily. {ECO:0000256|RuleBase:RU363087}.
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DR   RefSeq; XP_005183768.1; XM_005183711.3.
DR   STRING; 7370.A0A1I8N5P9; -.
DR   EnsemblMetazoa; MDOA011818-RA; MDOA011818-PA; MDOA011818.
DR   GeneID; 101901472; -.
DR   KEGG; mde:101901472; -.
DR   VEuPathDB; VectorBase:MDOA011818; -.
DR   eggNOG; KOG1511; Eukaryota.
DR   OrthoDB; 5472812at2759; -.
DR   UniPathway; UPA00057; UER00098.
DR   Proteomes; UP000095301; Unassembled WGS sequence.
DR   Proteomes; UP000694905; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004496; F:mevalonate kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019287; P:isopentenyl diphosphate biosynthetic process, mevalonate pathway; IEA:UniProtKB-UniPathway.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.70.890; GHMP kinase, C-terminal domain; 1.
DR   InterPro; IPR013750; GHMP_kinase_C_dom.
DR   InterPro; IPR036554; GHMP_kinase_C_sf.
DR   InterPro; IPR006204; GHMP_kinase_N_dom.
DR   InterPro; IPR006205; Mev_gal_kin.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR   NCBIfam; TIGR00549; mevalon_kin; 1.
DR   PANTHER; PTHR43290; MEVALONATE KINASE; 1.
DR   PANTHER; PTHR43290:SF2; MEVALONATE KINASE; 1.
DR   Pfam; PF08544; GHMP_kinases_C; 1.
DR   Pfam; PF00288; GHMP_kinases_N; 1.
DR   PRINTS; PR00959; MEVGALKINASE.
DR   SUPFAM; SSF55060; GHMP Kinase, C-terminal domain; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363087};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU363087};
KW   Kinase {ECO:0000256|RuleBase:RU363087, ECO:0000313|RefSeq:XP_005183768.1};
KW   Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516,
KW   ECO:0000256|RuleBase:RU363087};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098,
KW   ECO:0000256|RuleBase:RU363087};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU363087};
KW   Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW   Steroid biosynthesis {ECO:0000256|RuleBase:RU363087};
KW   Steroid metabolism {ECO:0000256|RuleBase:RU363087};
KW   Sterol biosynthesis {ECO:0000256|RuleBase:RU363087};
KW   Sterol metabolism {ECO:0000256|RuleBase:RU363087};
KW   Transferase {ECO:0000256|RuleBase:RU363087}.
FT   DOMAIN          146..220
FT                   /note="GHMP kinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00288"
FT   DOMAIN          299..370
FT                   /note="GHMP kinase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08544"
SQ   SEQUENCE   393 AA;  43382 MW;  E1B18AB340C6C611 CRC64;
     MLNFQVKSPG KIILHGEHAV VYHKPALAAV VGVGTTLKFQ NTTEDSSKVS FKLEALNTIF
     EIDIASFNAF LKRCRSKFSE YKLDNAVQLL EEVRLELAKQ QDETIDLGSP KKQQTQKAFI
     SIYYLLAGAI LSSPVKDLEL QQPFTITIDT ELNIGAGLGS SASYGAALAS AFLAYAQHFD
     LTNYKDEENQ QLISLWAFES ERVMHGTPSG IDNTVCTYGG MLRFVKGQGF QPVKILRPLH
     ILLVDSKVKR STADIVAKVR HLGETFPEVI NAIWNACEAL VNTAIPLYEN FGTCQDDSEK
     FEKLEQLFQI NNDLMKAIGV THPKLEQIFS IAFKRGFFSK ITGAGAGGYA IVLLPENYAS
     NEVYWKLKEE LEGAGFGVHA TTAGGEGLRM EPL
//

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