ID A0A1I8N608_MUSDO Unreviewed; 1128 AA.
AC A0A1I8N608;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Integrin alpha-PS3 {ECO:0000313|RefSeq:XP_005192055.1};
GN Name=101890516 {ECO:0000313|EnsemblMetazoa:MDOA011908-PA};
GN Synonyms=LOC101890516 {ECO:0000313|RefSeq:XP_005192055.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA011908-PA};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA011908-PA}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA011908-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005192055.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_005192055.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR RefSeq; XP_005192055.1; XM_005191998.3.
DR STRING; 7370.A0A1I8N608; -.
DR EnsemblMetazoa; MDOA011908-RA; MDOA011908-PA; MDOA011908.
DR VEuPathDB; VectorBase:MDOA011908; -.
DR eggNOG; KOG3637; Eukaryota.
DR OrthoDB; 4246085at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; IEA:UniProt.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF83; INTEGRIN ALPHA-PS3-RELATED; 1.
DR Pfam; PF01839; FG-GAP; 3.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 2.
DR PROSITE; PS51470; FG_GAP; 5.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 26..1128
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5041477360"
FT TRANSMEM 1068..1090
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 114..175
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 278..335
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 336..397
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 398..453
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 462..522
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 509..644
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 647..758
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
SQ SEQUENCE 1128 AA; 124809 MW; 03FB2FB4D01B9239 CRC64;
MLPLKLMWPN IGILLLLLLT THVNCFNISP KPNIVVKDPG FVTDMPKYQS SYFGFALNLR
PLGIIVGAPR AQSTLEEQRA VNETGAIYRC TLTGTPKCNT YVFDDRGNIN VPVSEYSYDS
EMKDHQWLGA SIDGGRTDTD KLIVCAPRFI TPATNDYLMH GICYWINNTL TQNPVNVTRI
SPLRGKQEQV TDENGKRIYY YMLGEQGISA HVTPDNEEFL IGAPGIHTWK GSVIRYRKVV
DTDEPSLSRR DTSSVSRTRI TRQADVQPAP FTRYEVDIPN PKNFDQPDDS YFGYSVASGY
FDSNDRKKLL YVASAPQDNQ QSGLAYIFDF ARNSLNKLYV FRGTQFGEYF GYAVLAEDVN
GDGLTDVIVS APQHSISGSF DDGAIYVFLN EGNMNFERNT ILSPIRGKAR FGSTLTALGD
INHDGFNDIA VSAPFAKDGS VFVYLGSERG LRERHSQRFD FNSAQKSAYG QAMFGHGLSK
GSDIDGNGFN DFAIGAPNAE TVFVYRSYPV VSIKASISSA TREIKPEQTS FRVKVCYSII
TTSPKTQSQE LNMHVILDPQ VKRVQIASTN SNEMKFKSTA TTKEQCTEID CNVRFNVETI
FKPIEMELRY GLANGIPNTE EFCETCAAVD PAEPSSHTEK IIFSTGCASE ICVADLQVKS
NLENKFVLGS SRTFSVSYDV SNNGETAYLP QINITSSNRM PFAKIPSNCK TNNQDVSLIC
DLNRGQPMAK GSKDTVTVIF DTSNISGQSM TIVAKVFSTG RELNDRDNIA SDVITLTEFT
EIVAVGKPIT EHINLEKAGN TAEVINLYDI KSVGPSNIGS MKVVFDIPVA YINSGNNKNI
PIIDLSNITM QAVYDSQIKD VQFYQNTTQI LMNAVEKTSS YSTQFTGKIA SIGDGAGNNN
GMHYDSTNMG HINEFNIREE SFGDSFMSGS ASRRRRRREA ATLTVNKENY ARIANPKSYE
LLGEDLKGTL PVNRTIVFNC NDPETTICVQ AVIPLYDFKP NKPLTVTMKY HVDLKAVNQI
LIEPWEFFVV VVGLNVQKTG DPLGTTLAVA KNIEYNIISK HQLYGTPIWV IIVSVIGGLL
VLALITYGMY KAGFFKRATK EEMDKLMHQA TLSTDGVTEA SNLNTAGN
//
