ID A0A1I8N7F0_MUSDO Unreviewed; 598 AA.
AC A0A1I8N7F0;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Beta-hexosaminidase {ECO:0000256|PIRNR:PIRNR001093};
DE EC=3.2.1.52 {ECO:0000256|PIRNR:PIRNR001093};
GN Name=101896517 {ECO:0000313|EnsemblMetazoa:MDOA012345-PC};
GN Synonyms=LOC101896517 {ECO:0000313|RefSeq:XP_005182019.1,
GN ECO:0000313|RefSeq:XP_011291863.1, ECO:0000313|RefSeq:XP_011291864.1,
GN ECO:0000313|RefSeq:XP_011291865.1, ECO:0000313|RefSeq:XP_019891771.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA012345-PC};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA012345-PB}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA012345-PB};
RX PubMed=25315136; DOI=10.1186/s13059-014-0466-3;
RA Scott J.G., Warren W.C., Beukeboom L.W., Bopp D., Clark A.G., Giers S.D.,
RA Hediger M., Jones A.K., Kasai S., Leichter C.A., Li M., Meisel R.P.,
RA Minx P., Murphy T.D., Nelson D.R., Reid W.R., Rinkevich F.D.,
RA Robertson H.M., Sackton T.B., Sattelle D.B., Thibaud-Nissen F.,
RA Tomlinson C., van de Zande L., Walden K.K., Wilson R.K., Liu N.;
RT "Genome of the house fly, Musca domestica L., a global vector of diseases
RT with adaptations to a septic environment.";
RL Genome Biol. 15:RESEARCH0466.1-RESEARCH0466.16(2014).
RN [2] {ECO:0000313|EnsemblMetazoa:MDOA012345-PC}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA012345-PC};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_005182019.1, ECO:0000313|RefSeq:XP_011291863.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_005182019.1,
RC ECO:0000313|RefSeq:XP_011291863.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine
CC residues in N-acetyl-beta-D-hexosaminides.; EC=3.2.1.52;
CC Evidence={ECO:0000256|ARBA:ARBA00001231,
CC ECO:0000256|PIRNR:PIRNR001093};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
CC {ECO:0000256|ARBA:ARBA00006285, ECO:0000256|PIRNR:PIRNR001093}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_005182019.1; XM_005181962.3.
DR RefSeq; XP_011291863.1; XM_011293561.2.
DR RefSeq; XP_011291864.1; XM_011293562.2.
DR RefSeq; XP_011291865.1; XM_011293563.2.
DR RefSeq; XP_019891771.1; XM_020036212.1.
DR STRING; 7370.A0A1I8N7F0; -.
DR EnsemblMetazoa; MDOA012345-RA; MDOA012345-PA; MDOA012345.
DR EnsemblMetazoa; MDOA012345-RB; MDOA012345-PB; MDOA012345.
DR EnsemblMetazoa; MDOA012345-RC; MDOA012345-PC; MDOA012345.
DR EnsemblMetazoa; MDOA012345-RD; MDOA012345-PD; MDOA012345.
DR EnsemblMetazoa; MDOA012345-RE; MDOA012345-PE; MDOA012345.
DR GeneID; 101896517; -.
DR KEGG; mde:101896517; -.
DR VEuPathDB; VectorBase:MDOA012345; -.
DR eggNOG; KOG2499; Eukaryota.
DR OrthoDB; 178991at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd06562; GH20_HexA_HexB-like; 1.
DR Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR025705; Beta_hexosaminidase_sua/sub.
DR InterPro; IPR015883; Glyco_hydro_20_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR029018; Hex-like_dom2.
DR InterPro; IPR029019; HEX_eukaryotic_N.
DR PANTHER; PTHR22600; BETA-HEXOSAMINIDASE; 1.
DR PANTHER; PTHR22600:SF42; BETA-N-ACETYLHEXOSAMINIDASE; 1.
DR Pfam; PF00728; Glyco_hydro_20; 1.
DR Pfam; PF14845; Glycohydro_20b2; 1.
DR PIRSF; PIRSF001093; B-hxosamndse_ab_euk; 1.
DR PRINTS; PR00738; GLHYDRLASE20.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF55545; beta-N-acetylhexosaminidase-like domain; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|PIRNR:PIRNR001093};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR001093};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..598
FT /note="Beta-hexosaminidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014271646"
FT DOMAIN 73..189
FT /note="Beta-hexosaminidase eukaryotic type N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14845"
FT DOMAIN 214..556
FT /note="Glycoside hydrolase family 20 catalytic"
FT /evidence="ECO:0000259|Pfam:PF00728"
FT ACT_SITE 379
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001093-1"
SQ SEQUENCE 598 AA; 68677 MW; 1B8D6E9D229B59CC CRC64;
MIWKYAVVSL IFVQQLVTIS AFGSPAIEPD TSNQWICTST ELCQLDDAAN IGDAKRYESQ
HDCRMSCGKY GAIWPMPTGS CSLAQERIHF DPWKVRFNVV APSPASTQFI RETNRIFVSN
IIKECLRNCT LEQSKEVLVK ATVNSSDLTL DWSTDESYQL VIRTTGTATF VDIKAPTVYG
ARHAFETLSN LITGCKDNGL LMVSSARVTD RPIYPHRGVL LDTARNFMPL KQIRNTIDAM
AASKMNVFHW HVVDTHSFPL EITRVPEMQR FGAYGAGNTY SRIETSNMIK YARLRGIRVL
IEIDGPSHAG NGWQWGPMAG MGNMAVCINQ KPWRNYCIQP PCGQLNPLNS NMYSIMKEIY
EDLAEVGPPE ETIHMGGDEV YISCWNNTQE ITKKMREMGY DLSLDSFYKL WSQFHEKNLE
SWDEVNQRQY PHLKVPKSTI VWSSHLTDPE HIEKYLPKER FIIQTWVSAD DPLNPVLLRK
GYRVIVSTKD AWYLDHGFWG RTQYYNWAKV YNNKMENNSN ILGGEVCMWS EYVDQNSVEA
RIWPRAGAAA ERLWSNPKTN SLQAQYRFYR YRDRLISRGI RPDAVVPKWC ILNEGHCF
//
