ID A0A1I8N8P3_MUSDO Unreviewed; 3256 AA.
AC A0A1I8N8P3;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=histone acetyltransferase {ECO:0000256|ARBA:ARBA00013184};
DE EC=2.3.1.48 {ECO:0000256|ARBA:ARBA00013184};
GN Name=101894311 {ECO:0000313|EnsemblMetazoa:MDOA012726-PA};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA012726-PA};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA012726-PA}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA012726-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EnsemblMetazoa; MDOA012726-RA; MDOA012726-PA; MDOA012726.
DR VEuPathDB; VectorBase:MDOA012726; -.
DR eggNOG; KOG1778; Eukaryota.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0140297; F:DNA-binding transcription factor binding; IEA:UniProt.
DR GO; GO:0004402; F:histone acetyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:UniProt.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR CDD; cd05495; Bromo_cbp_like; 1.
DR CDD; cd15557; PHD_CBP_p300; 1.
DR CDD; cd15802; RING_CBP-p300; 1.
DR CDD; cd02337; ZZ_CBP; 1.
DR Gene3D; 2.10.110.40; -; 1.
DR Gene3D; 3.30.60.90; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 1.10.246.20; Coactivator CBP, KIX domain; 1.
DR Gene3D; 1.20.1020.10; TAZ domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR031162; CBP_P300_HAT.
DR InterPro; IPR013178; Histone_AcTrfase_Rtt109/CBP.
DR InterPro; IPR003101; KIX_dom.
DR InterPro; IPR036529; KIX_dom_sf.
DR InterPro; IPR010303; RING_CBP-p300.
DR InterPro; IPR038547; RING_CBP-p300_sf.
DR InterPro; IPR035898; TAZ_dom_sf.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR000197; Znf_TAZ.
DR InterPro; IPR000433; Znf_ZZ.
DR InterPro; IPR043145; Znf_ZZ_sf.
DR PANTHER; PTHR13808; CBP/P300-RELATED; 1.
DR PANTHER; PTHR13808:SF1; HISTONE ACETYLTRANSFERASE; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF08214; HAT_KAT11; 1.
DR Pfam; PF02172; KIX; 1.
DR Pfam; PF06001; RING_CBP-p300; 1.
DR Pfam; PF02135; zf-TAZ; 2.
DR Pfam; PF00569; ZZ; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM01250; KAT11; 1.
DR SMART; SM00551; ZnF_TAZ; 2.
DR SMART; SM00291; ZnF_ZZ; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF47040; Kix domain of CBP (creb binding protein); 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF57933; TAZ domain; 2.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS51727; CBP_P300_HAT; 1.
DR PROSITE; PS50952; KIX; 1.
DR PROSITE; PS50134; ZF_TAZ; 2.
DR PROSITE; PS01357; ZF_ZZ_1; 1.
DR PROSITE; PS50135; ZF_ZZ_2; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00203}; Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00203};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00228}.
FT ZN_FING 495..581
FT /note="TAZ-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00203"
FT ZN_FING 2499..2580
FT /note="TAZ-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00203"
SQ SEQUENCE 3256 AA; 340052 MW; 87FC7BA2BB37F4DE CRC64;
MMADHMEEPP QKRMKVDDLY MLEENLPDEL VSTWGDQLGG GGPGSGPVSG GGPPNHGMAV
NVGGVGGPNK PPAQGPGPGG AGGPQLNGSV DDVNSAGGGP GGNPLRQMQH HQHLQHLLQQ
QGNKNPGMVG NTMGAAVMNQ LGSKSPNLQS PNAGGMQMCA IVNSMPMSIS NNGTQMNSMS
GMNTIAQGNM GNMVLTNSGM GGMGVGGAGM IKQQIGAGPG GMMNAGPGGV GPVGPGNMGP
AVGGPQQGMH MGGPGGHPQV MQNGPMMRMV GQHMLRGQNP HLMGGNGPGG IGGGPRMQNP
NMQMGQMNNM VGGGVGPNGP YGGGVGVGNV GNYGGPGGPQ GGINVNANNP QQQMLAQQIA
AQHGGVPPNM TAAMQQGQRG PGGVPLGMGG AGVGGGDGNG AGLVGGPQQQ QMNNAQMNPN
QQQNPQGGLM GGIRPPQTGP GGPQQNSMML SQQQQQQQQQ QQPGTSQQGG NAGGGGNAGA
GSGAGGGGTG SQPITEERKK QIQQQLMLLL HAHKCNRRES LNPNREKCNV PYCKPMQDVL
THMANCKQSR DCTVQHCISS RQILMHYKQC QRTDCIICFP FRQNHAFQNN NPNAAGGNAG
GGGGSNANQQ VGQPNANDKQ VPGGVGGPQQ VGGPQQSGGV GGVQPGGGGV APNVTAGAGG
MPVGAGVVGQ GQMNMKPNAG DMQQQMQNAP QNPNQEIRRF DSMGMQGAVG NAGGPNNMMQ
GNAVNVQQQQ MQGIRMTGVP PTARVMSTAV GGPGGGGVAV GPSSGGSNDQ AGMRQVVNNL
LISGGGNGPG TDGGIQNQQQ QMLLQGGPGG PNKFQMSAPP TPRLSDLLKP GLKVTTDPTQ
VQSNALNQQQ QQQQQQSNIP LSVNVHNNFN NSNINNLLGG GGGGNAGDMM GAGGPVGGAP
PNKQLTPQEL AKMKMQAQAS GGAGGLVGGP NNTASNNNVT GNQNATGGPG MQGGGVASVS
GGANNAGAGG APTTSQNTGG VAGGGTGGTG STSGGGGGDE NKDWREIITD DLRKHLVHKL
VQSIFPTFDP ATILDKRLHY LVSYAEKVER DMYEMAKCRS EYYHLLAEKI YKIQKELEEK
RIKKKEQQLL QMQQQQQQQQ GVGAGGVGAG PSNAAGGGVN VGGVGSGPSS ASGLPGQQIP
PGHPGQQQIR PMVSPMGGGG VGPGGPVGPN QGGGMPMGGG SMMQLRGQAP GNVGGGGLMP
GQNMGGMRSH SPGGNMLAMQ QQQQQQQRMQ FPQQGNMLVG PPGPSPGGNS MGGGISASQQ
SMVVPNPVLS PFTGQAMQGQ PGTGGVAGVL TSPIPGQQQQ FINANGGTGA FTAQQLIDNL
KRERMMQQQQ QQQQQQSGML MPQSPFNNSN NNNAGNTQMS QQSNAFTSPM SQQQQQQKPN
MMANAGGGNM GNMPPTPTSM ESLSAVIGGG TSASGPTSVT STASAGTVGA AGGMVAAPSP
SPSFTTNGPI GTPINNNPPS VPSSLMQTIG GDRGNTPPPA TSVNPSSPAS ANATPAATTA
SSTGTVGLQP SSTPSNTTPT SSAPATVASS SSSATITTTT TTATLSSSST TSASATTSVV
STSAGTCPTA ITSSMSSSSS TTTTAVTETS VASNGLAQNQ QQTTSMGKGN TGGTSTTTTT
TSAISSALPS TRPVSSSNSL SSQMAALEAA ARDNDDDPPN SPNSDSQNAG KSCKGKLDSI
KQEDDLKKEF MDDGSAGENS QQESSAGVGK NVNNDGTAKV EVKTEDCDVK IKLEPMEVDD
AAGAGSGANS TYTTSGEAAK AVGTGDSKDG VKPMTDGNSA AGSDVKVKSE TKPVAPEPLM
PNAGDKKKKC VFDPEELKQA LLPTLEKLLR HEPESVPFRN PVDPQALGIP DYFEIIKKPM
DLGSIRNNLM NGKYNDPWEY VDDVWLMFDN AWLYNRKSSK VYKYCTKLSE VFEQEIDPVM
QTLGYCCGRK YTFNPQVLCC YGKQLCTIPR DAKYYSYQNR YTFCQKCFND IQGDTVTLGD
DPLQSQTQIK KDQFKEMKND HLELEPFVDC QECGRKQHQI CVLWLDSIWP GGFVCNRCLE
KKDSKRKENK FNAKRLPTTK LGIYIETRVN NFLKKKEAGA GEVHIRVVSS SDKCVEVKPG
MRRRFVENGD MSAEFPYRAK ALFAFEEVDG IDVCFFGMHV QEYGSECPPP NTRRVYIAYL
DSVHFFRPRQ YRTAVYHEIL LGYMDYVKQL GYTMAHIWAC PPSEGDDYIF HCHPTDQRIP
KPKRLQEWYK KMLDKGMIER TIQDYKDIMK QAVEDKLSSA AELPYFEGDF WPNVLEESIK
ELDQEEEEKR KQAEAAEAAA AAAANIFSIE DNDVSGDGKK KGQKKAKKSN KSKAAQRKNN
KKSNEQQAGN DLSTKIYATM EKHKEVFFVI RLHSAQSAAS LAPIQDPDPL LQCDLMDGRD
AFLTLARDKH YEFSSLRRAQ FSTLCMLYEL HNQGQDKFVY TCNNCKTAVE TRFHCTVCDD
FDLCTLCYEK IGHPHKMEKL GFDLDDGSSP ADLKQANPQE ARKQSIQRCI QSLVHACQCR
DANCRLPSCQ KMKRVVQHTK NCKRKTNGGC PICKQLIALC CYHAKHCQEQ KCPVPFCPNI
KHKLKQQQLQ QKLQQQQLLR RRVALMSRTV TAPAALPGPA AVSNPVVVPS GVPVPNVAMV
TPMVIGGQPA IMPAGAAGAM SPSTVPVPSP VAAPIGGGMT SPHAHQPGMG MKPGGGHSPS
PNVLQVVKQV QEEAARQQVP HGGGFGKGGA MAPPVMQRHH MGGLPNQPNP GMVGNVGNVP
VGTVGPMGPG GNNVMGNNLL PMDQWGNRYP NNNVNQGMRQ PNQNQVMQPN AMQQQGMMGG
MVSAAGSQQM PGSSGNMPGN AQGIGGIGGN TTGMVGMGGA GPMGGGPGAG IRPQGQHPNA
GGVGGTGQMP NGPRNKQLNT QQLDQVMEKI KTDPTNEGHL QILQVLKQNP QIMAELIKRQ
QRQNNANAGG RQQSAGGGAG GSGVGSAVNG PQQQQQQQQL QQQQVMQQQQ QMQHMMSQQQ
QMPQQQQVMM QQQQQNVGQH QRMPGMQNPM MMQQQQQGQA TNAQWYKMRQ MPNYPPPYRQ
RAPQQMGGVG GPGQQFGGVG SFGGPGGGAP TGGPVDQYAA MQQGLKPSPQ QQMAGMPGVQ
QQQIMQGAGG MVGGPNVMGP PTPHTLQQQL MQQSSRASPP IRSPQPTPSP RSAPSPRAGP
SASPRAQPSP HHAMSHSPAP QTSHDGLHNH GGMHPHQSPL PGVPQDVVGG VGGVVGGPGG
PVSDASDQLT KFVEQL
//
