ID A0A1I8N9I9_MUSDO Unreviewed; 917 AA.
AC A0A1I8N9I9;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=DNA mismatch repair protein spellchecker 1 {ECO:0000313|RefSeq:XP_011294478.1};
GN Name=101891948 {ECO:0000313|EnsemblMetazoa:MDOA012977-PB};
GN Synonyms=LOC101891948 {ECO:0000313|RefSeq:XP_011294478.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA012977-PB};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA012977-PB}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA012977-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_011294478.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_011294478.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|RuleBase:RU003756}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|RuleBase:RU003756}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_011294478.1; XM_011296176.2.
DR STRING; 7370.A0A1I8N9I9; -.
DR EnsemblMetazoa; MDOA012977-RB; MDOA012977-PB; MDOA012977.
DR GeneID; 101891948; -.
DR KEGG; mde:101891948; -.
DR VEuPathDB; VectorBase:MDOA012977; -.
DR eggNOG; KOG0219; Eukaryota.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF35; DNA MISMATCH REPAIR PROTEIN MSH2; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003756};
KW DNA repair {ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003756};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003756}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905}.
FT DOMAIN 739..755
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
SQ SEQUENCE 917 AA; 103527 MW; 6DE606D08580D168 CRC64;
MDKQAPQLNM DTNSRRNFIR FFKSLGEKPS TTVRFFDHSD CYTVHGKDDA NLIARMVYKS
TAYITEMIPD DATSIPHVTL YKNKFESAVR ELLLVRNYRV EVYVRSATGN ANWNLEYRGS
PGNLLQFEDI IFTNKEELVG NSILSLQMRM NNNARNIGVV AVEQNDCLFQ VLEFVDDDFL
TELEATVVLL GPKECLLPSQ EGEYEAVKNL LERNGIMVTV ASKSQMASEK NDLIQDLNKL
LRFNKGQQED ATGLPELTFT IAMEALKLAI KYLALMSDSS NLGHYTLQQL NLKRFVHMDA
AAVSALNILP KPGTHPSSPA YRWQSVLGVL DRCNTPQGHR LMAQWVKQPL RSREILNDRH
DIVQCFIESP NSLNSLYEDF LKRIPDILML TKKLLRKKAN LQDIFRIYQV LLRTPKIINL
LKSLENSTVK NVICEPMQNF LEDLSGLKQM VEQVMDFDAI ENGEYLVKAS FDSDLLDMKE
RMDHLLEKME RCQDKANRDL DLDKNSVKLV NVPNVGYTLR ITLKDDTVLR KNKEYKIIDV
LRGGIRFTTD KLSSINDEFV TLRSQYEEQQ KTIVEEIIKV AVGYASPLTS LNNEFAQLDC
LVSFAIAAQS APIPYIRPQI LEEGSGELVL KDIRHPCLEL QEHISFIANS VEFKKDVCNM
FIITGPNMGG KSTYIRSVGT AVLMAHVGSF VPCSEATISM VDSILGRVGA SDNIIKGLST
FMVEMIETSG IIRSATEKSL VIIDELGRGT STYEGCGIAW SIAEHLAKET KCFTLFATHF
HEITNLSETV PTVKNCHMAA VADNDNFTLL YQVRPGVMEK SFGIQVARLA NFPEKVVHHA
QQVYNEFEDE HADKQSCDDK VLLEKINKAI ENLSTTGNNV DINESDLSKL VEQFTQDIRK
LDSEYFKCVL ATAGATE
//
