ID A0A1I8NCH2_MUSDO Unreviewed; 1210 AA.
AC A0A1I8NCH2;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=BK channel {ECO:0000256|ARBA:ARBA00029579};
GN Name=101896394 {ECO:0000313|EnsemblMetazoa:MDOA013788-PM};
GN Synonyms=LOC101896394 {ECO:0000313|RefSeq:XP_011291912.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA013788-PM};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA013788-PM}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA013788-PM};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_011291912.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_011291912.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_011291912.1; XM_011293610.2.
DR EnsemblMetazoa; MDOA013788-RM; MDOA013788-PM; MDOA013788.
DR GeneID; 101896394; -.
DR VEuPathDB; VectorBase:MDOA013788; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:UniProt.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003929; K_chnl_BK_asu.
DR InterPro; IPR047871; K_chnl_Slo-like.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR048735; Slowpoke-like_C.
DR PANTHER; PTHR10027; CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN; 1.
DR PANTHER; PTHR10027:SF33; CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1; 1.
DR Pfam; PF03493; BK_channel_a; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF21014; Slowpoke_C; 1.
DR PRINTS; PR01449; BKCHANNELA.
DR PRINTS; PR00169; KCHANNEL.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303,
KW ECO:0000313|RefSeq:XP_011291912.1};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 45..66
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 124..142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 162..181
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 246..267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 282..301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 308..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 124..339
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 491..579
FT /note="Calcium-activated potassium channel BK alpha
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF03493"
FT DOMAIN 1051..1170
FT /note="Ca2+-activated K+ channel Slowpoke-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21014"
FT REGION 695..753
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 772..793
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1180..1210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 696..751
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 772..788
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1188..1210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1210 AA; 134804 MW; 72FDEF3C80FF15D9 CRC64;
MANLTDLDQA FDGMSGCDQS TVESLAEDPT GSPFEVDDCL KVRKYYCFLL SSIFTFLAGF
LIVLLWRAFA FICCRKEPEL GPNDPKQKEQ KASRNKQEFE GTFMTEAKDW AGELISGQTT
TGRILVVLVF ILSIASLIIY FVDASNEEVE RCQPWSTNIT QQIDLAFNIF FMVYFFIRFI
AASDKLWFML EMYSFVDYFT IPPSFVSIYL DRTWIGLRFL RALRLMTVPD ILQYLNVLKT
SSSIRLAQLV SIFISVWLTA AGIIHLLENS GDPLDFNNAH RLSYWTCVYF LIVTMSTVGY
GDVYCETVLG RTFLVFFLLV GLAMFASSIP EIIELVGSGN KYGGELKREH GKRHIVVCGH
ITYESVSHFL KDFLHEDRED VDVEVVFLHR KPPDLELEGL FKRHFTTVEF FQGTIMNPID
LQRVKVHEAD ACLVLANKYC QDPDAEDAAN IMRVISIKNY SDDIRVIIQL MQYHNKAYLL
NIPSWDWKQG DDVICLAELK LGFIAQSCLA PGFSTMMANL FAMRSFKTSP DTQAWQNDYL
QGTGCEMYTE TLSPSFTGMT FPQASELCFS KLKLLLLAIE IKGNEDGADS KISINPRNAK
IQANTQGFFI AQSADEVKRA WFYCKACHED IKDETLIKKC KCKNLAVQPR NKFDDLDVGM
IMMQTGMVNQ GITSAINQME GDITRDREDM NLLNRHNRRP NGSTSLAPGN GTTGLHPSGT
VKQVNKVKPT VNRQQLEGQV MSPSQYNRPP ENEANPYAGY QLAYEVKKLM PTSRSTGTGS
QNPNGSVSLP AGIADDQSKD FDFEKTEMKY DSTGMFHWSP AKSLEDCILD RNQAAMTVLN
GHVVVCLFAD PDSPLIGLRN LVMPLRASNF HYHELKHVVI VGSVDYIRRE WKMLQNLPKI
SVLNGSPLSR ADLRAVNVNL CDMCCILSAK VPSNDDPTLA DKEAILASLN IKAMTFDDTI
GVLSQRGPEF DNLSAAAGSP IVLQRRGSVY GANVPMITEL VNDSNVQFLD QDDDDDPDTE
LYLTQPFACG TAFAVSVLDS LMSTTYFNQN ALTLIRSLIT GGATPELELI LAEGAGLRGG
YSTPESLSNR DRCRVGQISL YDGPLAQFGE CGKYGDLFVA ALKSYGMLCI GLYRFRDTSS
SCDASSKRYV ITNPPDDFSL LPTDQVFVLM QFDPGLEYKP PAVRAPTGGR NANTQGSGVG
GGGSNKDDNS
//
