ID A0A1I8NDU1_MUSDO Unreviewed; 2399 AA.
AC A0A1I8NDU1;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=PH domain-containing protein {ECO:0000313|EnsemblMetazoa:MDOA014171-PN};
GN Name=101897407 {ECO:0000313|EnsemblMetazoa:MDOA014171-PN};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA014171-PN};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA014171-PN}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA014171-PN};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR STRING; 7370.A0A1I8NDU1; -.
DR EnsemblMetazoa; MDOA014171-RN; MDOA014171-PN; MDOA014171.
DR EnsemblMetazoa; MDOA014171-RO; MDOA014171-PO; MDOA014171.
DR VEuPathDB; VectorBase:MDOA014171; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR CDD; cd13248; PH_PEPP1_2_3; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR040392; PKHA4-7_PH.
DR PANTHER; PTHR12752:SF9; KRAMER, ISOFORM I; 1.
DR PANTHER; PTHR12752; PHOSPHOINOSITOL 3-PHOSPHATE-BINDING PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}.
FT DOMAIN 430..529
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 58..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 125..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 225..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 304..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 379..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 532..669
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 991..1040
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1060..1125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1139..1196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1216..1235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1760..1784
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1830..1930
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1946..2011
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2042..2064
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2080..2139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2155..2186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2345..2399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 186..215
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1605..1663
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1715..1753
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 58..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 304..327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..354
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..397
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 532..595
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 627..669
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 991..1025
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1060..1083
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1096..1113
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1762..1784
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1830..1899
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1900..1921
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1976..1990
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1991..2011
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2042..2063
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2351..2389
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2399 AA; 264531 MW; 9624C2CE1C5CB088 CRC64;
MFGCIYQLWD WLEAPPLFSA ATMDAKKLQQ LQQSQNVQKK IPLAYQTNIA DYRTATHSPV
FQQQQQQHHH QQQHGNYHMS SAHMNSGSAG HYQQSPTTTS SSGGGPLSPI DIQPQASKLL
LKHQLQNSGS GGSSIQSSPY HQASISSGYP TSSGGGTDQL YQSPPERTYM QAAGRLGSSN
ATSMALQQQY QQMQQAKLQA QIASQNEAIQ QQQQRNFAMR QAMNSAVPQG HYHMSQQQQQ
QQQQSTASQQ QHRAPPSSLN LTNQFQPASG PLKVNQQNSQ KSSQQYQQQQ QQQQQQQQQQ
QQQQQQQEQI YGHHQHSQHS AQPVFQQMHH HALQHRSKSD LQTPGSNDQS PIYIQQNHPG
HVVNQAVQTQ ISTVAKATTI TKTPSSEDSS SASAKSPTHA PLDRKKSAGS SNSQAQALKS
PITKRPPNSP VTISGWLYKQ GSDGLKVWRK RWFVLAEYCL YYYKSPDEEK VLGSILLPSY
KVSACLPEDK IYRKFAFKCE HQNMRTYWLA AENAESMVQW VRALSAATMM QAHGSAGDSS
EHPSGSSSVN HSGENSDSGI NTLQSKMSGQ GQVTPASDNG GGVTASSSNS GGGAQPLYAN
APPKPRRITD GGYSSPSPEH SVDNERTRSS QPQTTSRRSG IMSPTLQQMQ QHQYQQQQQQ
QQQQRSQHHA IYDTRTGNVS SAIRIPQGQA NYNLDNLESQ YQQQLTLSPE EYPSSPLGSP
SQYMDAQMEQ QIMQLQQQRM AVDDIYGERE LYMQRLIQQR YPPNMAGYGA AERRTPDAYG
RSKNRLFSDY EDIYNLTAAE TAAQAALLQE AASYRRPLSP PSYEDNKYLP TVPSRYTPNH
LELSAVGSNL NLRSRPTAGL VRPHSADFLE YEARAEAASD AAAVAAATAM IKPDPVRAPR
PKSSLDINRT PDSFYYSEEN YAEKMRKSAL YLQNPQAQPQ PAAGSYRMAT GSTDFLSPVA
SGMNTIAYEN PYERIYKRNE LLQDALGNQA GHTSIPRMSR SQTMGNGAQI RSSSTHPHHP
LSPTGTTYPQ QPPPLHTPLL SSGLTTQEII QQNEQFLRSA SARLPKRSST FDDEPLSTTT
TTTTPTSPPP PSTGTTAATT PTANGSNSAA ATSAHLEGER KREESMKRLL EWKQRMLQSP
LTRKSAQHVS NSASAATLVG QKTNGSSATS SAATKLGSNN DGNGKPSSSS NLTAMSKLGS
NPNILLTSTT VASGIHLGGG GPKGSTSMAG GSTAGIIQRR RSESQAISGT TATAAGYNSY
SSDDEASISV RNVKNLPIGN LTVKPDPSDT LLHRQMDLYD YEQMQQLENS YYGTSQDMKY
AKTTMLNDRS LGGLGGTLSG SSYGIGGGGG GVGGGYLTST PLHASNSNIG LGLDYLGNLD
TTAGHNIYDM HNQYQQQLHR MYQQQQLQQQ MASAAYPMRR YGSRAEIDIL ERETSSQIRN
LDVSAGDLLS RTHEELVLLL IQLRRQNSNT ARAIEQCCSD IHDVQNRLLT AEGLTRAESI
QRLDYLKQHL LDLERQYEKS KPLVNLVDNM VKLGSLYRND ALGRTTTTAI TPRTDPVSLE
RLEFNQRIQE KRLLQEEQQQ WDRLEPDNNE LQSKVAQLYH LDQLLQEESG TLQSLQRDKE
DLERALGGIK ARIQDTRETP MALEAAKKQQ HLLERELSRV HQLLAENSKV AEKLEMTVAG
NTRLEQELLI LRQKLTRGSQ VKISDTYASN TTAMLESELK RVQNLVGDMQ RQRQELSQAV
KQLTENSTKL YQEIGNKDYL RNAEPNSGSS SSGGNGSSSG GGSIKKRTNS GCWFETDLDS
MTSVNRGLSD SSMNLSTPLF VDTNNTSGHL LNSSSTSSKL SDYNTGDSMQ NESHRRGGSS
AASYRYNDSS DNLETSGVDS DGFLESNPFA NLSQQEKQEI KTVRIVKRES ERRHRDRSER
SGLSNSTQNL DQVMEEEQYG LMNGSLAAAG GNYHSEEYKP NERSKSLPRT YSEPPKSSRH
HHRHKHGSTN SHHNTASSSS SSANNASSSS SAAYHSTYKN DYYGGHNGHA AAAVSVSNGY
DKNSNYSHQN HAAASNNGHG SASAREHLNP LANAYFAKQM QQGGHSTTTT TIATSSSSSS
SNHHYSTTST SSHSRHSSQS ALRQKTDSQQ SLNKSLSDLT PSFQSEVARQ IMNEMSAGSA
SEDTEKIVEK VPSQHKHRRA VPKEKRRHYT APNNVVNVKS AENGHSENDM NKNNTNWRAR
DDLDMEVALR PRINAPDVVR SALRHGEKIS ENTIDNLLLA PNKIVIPERY IPETTPELSP
EEKKRRQEKV ESIKKMLSEA PIAANDTAAS LPPSKINEEK KQREHLLQMN QILAQQVMQM
SKIVAEKAMS KNGNGEKDDE GNSQDTMSQR GNSDDDDGRK SESPSEPLPI HQKRDNFYS
//
