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Database: UniProt
Entry: A0A1I8NDX3_MUSDO
LinkDB: A0A1I8NDX3_MUSDO
Original site: A0A1I8NDX3_MUSDO 
ID   A0A1I8NDX3_MUSDO        Unreviewed;       369 AA.
AC   A0A1I8NDX3;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   24-JAN-2024, entry version 38.
DE   RecName: Full=Glutamine synthetase {ECO:0000256|ARBA:ARBA00012937, ECO:0000256|RuleBase:RU004356};
DE            EC=6.3.1.2 {ECO:0000256|ARBA:ARBA00012937, ECO:0000256|RuleBase:RU004356};
GN   Name=101895666 {ECO:0000313|EnsemblMetazoa:MDOA014195-PA};
GN   Synonyms=LOC101895666 {ECO:0000313|RefSeq:XP_005184065.1};
OS   Musca domestica (House fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC   Muscidae; Musca.
OX   NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA014195-PA};
RN   [1] {ECO:0000313|EnsemblMetazoa:MDOA014195-PA}
RP   IDENTIFICATION.
RC   STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA014195-PA};
RG   EnsemblMetazoa;
RL   Submitted (JAN-2021) to UniProtKB.
RN   [2] {ECO:0000313|RefSeq:XP_005184065.1}
RP   IDENTIFICATION.
RC   STRAIN=Aabys {ECO:0000313|RefSeq:XP_005184065.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine +
CC         phosphate; Xref=Rhea:RHEA:16169, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:28938, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58359, ChEBI:CHEBI:456216; EC=6.3.1.2;
CC         Evidence={ECO:0000256|RuleBase:RU004356};
CC   -!- SIMILARITY: Belongs to the glutamine synthetase family.
CC       {ECO:0000256|ARBA:ARBA00009897, ECO:0000256|PROSITE-ProRule:PRU01330,
CC       ECO:0000256|RuleBase:RU000384}.
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DR   RefSeq; XP_005184065.1; XM_005184008.3.
DR   STRING; 7370.A0A1I8NDX3; -.
DR   EnsemblMetazoa; MDOA014195-RA; MDOA014195-PA; MDOA014195.
DR   GeneID; 101895666; -.
DR   KEGG; mde:101895666; -.
DR   VEuPathDB; VectorBase:MDOA014195; -.
DR   eggNOG; KOG0683; Eukaryota.
DR   OrthoDB; 1115057at2759; -.
DR   Proteomes; UP000095301; Unassembled WGS sequence.
DR   Proteomes; UP000694905; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004356; F:glutamine synthetase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006542; P:glutamine biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.10.20.70; Glutamine synthetase, N-terminal domain; 1.
DR   Gene3D; 3.30.590.10; Glutamine synthetase/guanido kinase, catalytic domain; 2.
DR   InterPro; IPR008147; Gln_synt_N.
DR   InterPro; IPR036651; Gln_synt_N_sf.
DR   InterPro; IPR014746; Gln_synth/guanido_kin_cat_dom.
DR   InterPro; IPR008146; Gln_synth_cat_dom.
DR   InterPro; IPR027303; Gln_synth_gly_rich_site.
DR   InterPro; IPR027302; Gln_synth_N_conserv_site.
DR   PANTHER; PTHR20852; GLUTAMINE SYNTHETASE; 1.
DR   PANTHER; PTHR20852:SF57; GLUTAMINE SYNTHETASE 2 CYTOPLASMIC; 1.
DR   Pfam; PF00120; Gln-synt_C; 1.
DR   SMART; SM01230; Gln-synt_C; 1.
DR   SUPFAM; SSF54368; Glutamine synthetase, N-terminal domain; 1.
DR   SUPFAM; SSF55931; Glutamine synthetase/guanido kinase; 1.
DR   PROSITE; PS00180; GLNA_1; 1.
DR   PROSITE; PS00181; GLNA_ATP; 1.
DR   PROSITE; PS51986; GS_BETA_GRASP; 1.
DR   PROSITE; PS51987; GS_CATALYTIC; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004356};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU004356};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU004356};
KW   Reference proteome {ECO:0000313|Proteomes:UP000694905}.
FT   DOMAIN          32..112
FT                   /note="GS beta-grasp"
FT                   /evidence="ECO:0000259|PROSITE:PS51986"
FT   DOMAIN          119..369
FT                   /note="GS catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS51987"
SQ   SEQUENCE   369 AA;  41372 MW;  B20353BEC7B320CB CRC64;
     MSNRILEDSP NAHINKTILD RYLSLPLKEN VVQATYVWID GTGEDLRCKD RTLDFIPSKP
     SDLPIWNYDG SSCYQALGSN SDTYLHPVAI YKDPFRRGNN ILVMCDTYKF DGTPTETNHR
     KTCLEVVNKC LDEEPWFGIE QEYTFLDFDG YPLGWPKNGF PGPQGPYYCG VGANKVYARD
     VVDAHYRACL YAGIKVSGTN AEVMPAQWEY QVGPCVGISI GDDLWMSRFL LHRIAEEFGI
     VATLDPKPMP GDWNGAGAHT NVSTKSMRED GGIKDIEQAV AKLSKHHDRH IRAYDPKQGQ
     DNARRLTGKH ETSSINDFSA GVANRGCSIR IPRGVNDEGK GYFEDRRPSS NCDPYSVVEA
     ILRTICLDE
//
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