ID A0A1I8NDX4_MUSDO Unreviewed; 337 AA.
AC A0A1I8NDX4;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=glutaminyl-peptide cyclotransferase {ECO:0000256|ARBA:ARBA00012012};
DE EC=2.3.2.5 {ECO:0000256|ARBA:ARBA00012012};
GN Name=101893544 {ECO:0000313|EnsemblMetazoa:MDOA014199-PA};
GN Synonyms=LOC101893544 {ECO:0000313|RefSeq:XP_005188431.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA014199-PA};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA014199-PA}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA014199-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005188431.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_005188431.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=N-terminal L-glutaminyl-[peptide] = N-terminal 5-oxo-L-prolyl-
CC [peptide] + NH4(+); Xref=Rhea:RHEA:23652, Rhea:RHEA-COMP:11736,
CC Rhea:RHEA-COMP:11846, ChEBI:CHEBI:28938, ChEBI:CHEBI:64722,
CC ChEBI:CHEBI:87215; EC=2.3.2.5;
CC Evidence={ECO:0000256|ARBA:ARBA00000001};
CC -!- SIMILARITY: Belongs to the glutaminyl-peptide cyclotransferase family.
CC {ECO:0000256|ARBA:ARBA00006014}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_005188431.1; XM_005188374.3.
DR EnsemblMetazoa; MDOA014199-RA; MDOA014199-PA; MDOA014199.
DR GeneID; 101893544; -.
DR KEGG; mde:101893544; -.
DR VEuPathDB; VectorBase:MDOA014199; -.
DR eggNOG; KOG3946; Eukaryota.
DR OrthoDB; 3091175at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0016603; F:glutaminyl-peptide cyclotransferase activity; IEA:UniProtKB-EC.
DR CDD; cd03880; M28_QC_like; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR037457; M28_QC.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR040234; QC/QCL.
DR PANTHER; PTHR12283; GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE; 1.
DR PANTHER; PTHR12283:SF7; GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..337
FT /note="glutaminyl-peptide cyclotransferase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041052598"
FT DOMAIN 99..320
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
SQ SEQUENCE 337 AA; 38867 MW; 7A8FF706844F1F6A CRC64;
MKVFTHFTHP RLLLLLVLGC CFQLHANGQL QSQQLVFPDD NAHFNKTLAN ILQPRVVGSI
GHTNVRNFIV SELNALGFTT EIDSFSQKVP IFGNVTFSNI VGVINPNAND FLALSCHYDS
KYFPKDPNFV GATDSAVPCA IMLNTAKTLQ PYLEQSFKNR QDLGLMLIFF DGEEAFREWS
NDDSVYGSRH LAKKYSNTKL KGNIRHIDRI EVLVLLDLLG APNPKFYSFY DNTDGLHKSI
HDIERQLAKQ KKLEGNNLMF MNRPAQGFVD DDHRPFLQEN VPILHIIPTP FPIVWHTPND
DATNLHWPTI RNFNKIFRTF VYEYLQRHME RINLRYF
//
