ID   A0A1I8NEG1_MUSDO        Unreviewed;      1186 AA.
AC   A0A1I8NEG1;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   24-JAN-2024, entry version 37.
DE   RecName: Full=RhoGEF domain protein {ECO:0008006|Google:ProtNLM};
GN   Name=101895828 {ECO:0000313|EnsemblMetazoa:MDOA014349-PB};
OS   Musca domestica (House fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC   Muscidae; Musca.
OX   NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA014349-PB};
RN   [1] {ECO:0000313|EnsemblMetazoa:MDOA014349-PB}
RP   IDENTIFICATION.
RC   STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA014349-PB};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
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DR   AlphaFoldDB; A0A1I8NEG1; -.
DR   STRING; 7370.A0A1I8NEG1; -.
DR   EnsemblMetazoa; MDOA014349-RB; MDOA014349-PB; MDOA014349.
DR   VEuPathDB; VectorBase:MDOA014349; -.
DR   eggNOG; KOG3519; Eukaryota.
DR   Proteomes; UP000095301; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR   CDD; cd01224; PH_Collybistin_ASEF; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   CDD; cd00174; SH3; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR45834:SF3; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 3, ISOFORM L; 1.
DR   PANTHER; PTHR45834; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 9-RELATED; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF07653; SH3_2; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
SQ   SEQUENCE   1186 AA;  131172 MW;  A58042039066E0B5 CRC64;
     MLNRKGSYTL TCAKLSQTSS PAAAATMLST IESASCLSFI ATTNMEETSS PPPACSPSPS
     STLSSACQSP SPASTSPPSS LATSRRASSL AMTKKRTALL AKSASAASAM QRRQRFPRTA
     TTNDSVSVIG VRNGFLTNLS QQMRAVSSPS LTDMGDHCQR VPSSSSSYTN NATTQTASQE
     DCCRANTTNN VATSAPVVAT QNVGVLQKFK RTLTNFNKHQ HQQQQQQSSN QAATHGGTSA
     AASSSSSSQN PSGGDNNCCN TTTATMTTTT SASGTFLMPD TEMSTDVTDS TSNKYRFGPL
     VWRSSKERRK TKYNRRDKCN SGDSGIQIEL ENDEQFARAL AANGGSGGCL MMNGSLNTSN
     GVTLMSNGRK SEGLNSLRFR QVRRTNSAKV TSMTDQSVSE VLNKAKMLKR MDINGEREAP
     ESLPTRSLSQ PNGLESCGMT RNDLDDSDSD SVTSHEEAPS CYYPIYAEVL YNFTAAGPQE
     LGLEKGTLIE ILRKEIGPWW FGRIKKEDAS LVEEILDPEL GWFPKEFVRV IHSPETDAFF
     LRHLADEEQR HKDQHINHMQ INELSSSTIV QQTTTTTSSS VVPAVGVDNQ MLLNTSSSAP
     CTPVNTSSED NCNTTIIDKH NVTTIVIETS SPPSTALLLE QQSSERTMDQ DEQQQQQQRD
     ASSTTTTTLT ANGQTVLSTS QSLNVIMGST EILRRSAVKE LLDTEVNYVK LLQAICEGYL
     PAMSKRIDIF SPNSIRLIFS NITAIYKFQR RFLEALRKGI EQNQVGKIFL KMHKGFLCYS
     TYCNSYPRAL IELESYERVK DARTILDNCR ESENLAELPL SAHLLAPVQR ICRYPLHLAE
     IMKTSAKGSE PTPFSLQEFE QIDVSQLDIP DTTETIDMAL EAMKSITEAV NEGKRHSETI
     ARHQASFQNF KGPPLHLHST RFFVQIDATR QKQNLWNSSC TLFLFDNQLV YCKRDIIKRS
     NFIYKGRIFL DRCRVVNVRD GKMFGHTIKN SLRIYCESRG KWFDFSFRSA NRKHRFLNTL
     ALERQFSGKS LYISEMMNFD YAFEERDCSD DQSDYEGAEN EQQKLKEFLY EANLNNGNNT
     NTSGESSVPE SPAKSFKYSD TLPKKSSHRL ESTANNETQT GSLGRRRLGN WFRKPKSTAS
     TPNQSPTHKS HPPAAHSTGD LQLSGTSDIN ESYTVLEHAD NGGVSS
//