ID A0A1I8NF62_MUSDO Unreviewed; 2194 AA.
AC A0A1I8NF62;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Protein sickie isoform X1 {ECO:0000313|RefSeq:XP_005179430.1};
GN Name=101887273 {ECO:0000313|EnsemblMetazoa:MDOA014547-PB};
GN Synonyms=LOC101887273 {ECO:0000313|RefSeq:XP_005179430.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA014547-PB};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA014547-PB}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA014547-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005179430.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_005179430.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the Nav/unc-53 family.
CC {ECO:0000256|ARBA:ARBA00006255}.
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DR RefSeq; XP_005179430.1; XM_005179373.3.
DR EnsemblMetazoa; MDOA014547-RB; MDOA014547-PB; MDOA014547.
DR GeneID; 101887273; -.
DR KEGG; mde:101887273; -.
DR VEuPathDB; VectorBase:MDOA014547; -.
DR eggNOG; ENOG502QPT3; Eukaryota.
DR OrthoDB; 4233432at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0022008; P:neurogenesis; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR CDD; cd21212; CH_NAV2-like; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR039041; Nav/unc-53.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12784:SF28; PROTEIN SICKIE; 1.
DR PANTHER; PTHR12784; STEERIN; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF00307; CH; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00033; CH; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50021; CH; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905}.
FT DOMAIN 35..143
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 146..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 227..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 336..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 384..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 499..554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 581..616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 629..673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 810..934
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1360..1418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1601..1701
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2169..2194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1269..1296
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1574..1601
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 250..285
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..409
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..432
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 433..487
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 504..525
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 533..554
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 581..600
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 629..671
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 810..881
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 897..918
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1360..1376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1385..1418
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1601..1626
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1657..1688
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2194 AA; 238998 MW; 30F3F135B973B284 CRC64;
MNETDYQISP LQFIDRTDKM PNLHFVDYNR KYSAQETIQI YTDWANYYLE RAKSKKKVTD
LSADCRDGLL LAEVIEAVTS FKVPDLHKKP KNQQQMYDNV NSCLNVLRSQ TVSGLDNITT
SDICCGRLKA VLALFFALSR FKQQSKQGKP NTTSGLSIKA DIHQQPNTTT TTQCAEKTTS
SANSTSTIQN IQNGNDSMVN RQIPQAYTKA NGTAIPLPAT VMVQRRCPPD KVRPLPPTPN
HAPSIPGLGK SGSEFNNSRP NSPPSSNHTI QNLKSGNNNG LRQPSIKSGI PAPGSALPTV
TGQQKHSMLD KLKIFNKDKQ PLLQQQQGQQ QTTLINANKN QVQSKRTSSS SGFSSARSER
SDSSLSLNDS HISQIKPPAI AVAATNKARE TKASAKQSKL LQAQTKKEQV KNASKTEKKE
KSPARSLNRE DINVDSKTST LSRNKNSLPR GKDSSLKPNT KSNLTSKSES KTSLIIPPSK
SLNSSNCIGG LPKPIAAIKG TSKLPHSPLQ NDNKGRLSSP NSAQEMIKRE KSDISSTSNI
SQQQTPSNHS TQLPTHIVKP VPMAEVHQNQ QRSPYYANAQ HIQQQQTLIQ PQQPPCSIQE
PTYNRLPPPK PSAIGTPTAL RKLEYNSGPS VLQPQQHSPL RSLTPAATHS QPVTPTSQQS
PLTNEGTPNK YHTIPSKIVG TIYEEDKPVS VLPMRPLLRG YNSHVTLPTR GARGTHNFIS
EYCENDINQG YCSDGDSLRF SNSRLGHSSS LQGSPRFHDI DNGYLSEGSS GIGCSQNGHH
IPHGKHFLSM MRARSQLPTT IEERIRNSRG SLDSLGTGAP SSSASQASSS VGSNNKMDIT
NGLNSSASNS ANNSPQHHNS GSPSHRSSPR NGNNWSKMPE ALNGQKSEHK EKSSPSRRNV
GSSSSKQSPS SSSRTKGVPP SFGYVKRSNG TATSTAEQQN IVMMMNTMSG CSPQNGRNTA
HVSAVPRTGA PGGRKMSGGA QTLPHDVSKM PPTTQHRSYS LTGPGATQLS QCIRERLAGS
HSLPKPGSDM HMFQHRLSNR SAKMLDGSLS DTQTYAEVKP EYGSYAMWLK HSNTAGSRLS
DGDSLENMHI NSPSMSRHNQ KLMQQRAVAA GNANCNTGAM AGTESPYVQS PRLNRSNSIR
STKSEQMYPP MMSRGSEVEI EPYYCLPVGT THNGVISAQM AAAAANAQSS TASGNTVAWS
QPTSPTPINR GFAGPMSPTH CNAAGMTNMS GTSSQSTSHR LTYPKKNDEV HGSAASLLSG
GSSLYGTSEE RQAHEIRRLK RELMEAREQV LSLSSQLSTN AHVVNAFEQS LSNMTSRLQH
LTATAERKDG ELTDMRQTIE LLRKQSIQAG LTTAHMQSMG VQTQSQTQND LLSQKPPPLP
TSIPGQHISR ATQHNLQQQS SSYGQTGAIQ RHHSSDSMCS VNSIGSSCST QDKKQKKKGW
LRSSFTKAFS RNAKISKTSR HGINIHGQQN TSHTNSNDNS IAAITGLNKT NGHMQADTQG
LSALATQQSP PLPTSPTNAC PTKTVTLIDN AKPIDAIEHE DTTHVVEDLK KQLREKDLVL
TDIRLEALSS ASQLEILKET VNKMRAEMMS LKQNNERLQK MVTSRSLAGS EASLGNAVSP
NGSIGESRRY SLADGNTRPP MELPKRLEEE AEEDNTPPAP APEPPPPPLS PTTHIDLTPP
PPALDTIPSP AHVPTTAEEM PDINDGKKIA IACYLGQPES FAKYCEEMLE VDDFYANTSM
IGSNLAESGE RKSFPITTPN EFVIAYTYIS GKTSWQNLDY IVRKTFKDYV SRVDPGTNLG
LNTDSITSYH LGEAKRGPEM GFPELLPCGY IVGNVRTLYI CLQGVGSLAF DSLIPRSIVH
RYISLLTEHR RLILCGPSGT GKSYLARRLA EFLVARSGKG NPSEAIATFN VDHKSSKELR
QYLGHVAEQA AIANRASELP SVIILDNLHH ASALGDVFSC LLSAGPAAKL PCIIGTMSQA
TCNTTNLQLH HNFRWVLTAN HMEPVKGFLG RFLRRRLFQL ELQTQHPQPE LAAVLAWLPT
VWQHINRFLE AHSSSDVTIG PRLFLGCPLD LKESQVWFTD IWNYHLSPYL IEAVREGVQL
YGRRGGAWND PSAFIRNSYP WPYGPDSVPP LRQINAEDVG LEGVAANSCD NQDPLLNMLM
RLQEAANYSE NQDQESDCAS LDSNITPDSS AGAE
//
