ID A0A1I8NFP9_MUSDO Unreviewed; 951 AA.
AC A0A1I8NFP9;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Uncharacterized protein LOC101891514 isoform X13 {ECO:0000313|RefSeq:XP_005178572.1};
GN Name=101891514 {ECO:0000313|EnsemblMetazoa:MDOA014695-PG};
GN Synonyms=LOC101891514 {ECO:0000313|RefSeq:XP_005178572.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA014695-PG};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA014695-PG}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA014695-PG};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005178572.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_005178572.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_005178572.1; XM_005178515.2.
DR EnsemblMetazoa; MDOA014695-RG; MDOA014695-PG; MDOA014695.
DR VEuPathDB; VectorBase:MDOA014695; -.
DR OrthoDB; 3136699at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005254; F:chloride channel activity; IEA:UniProt.
DR GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR CDD; cd18987; LGIC_ECD_anion; 1.
DR CDD; cd19049; LGIC_TM_anion; 1.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR InterPro; IPR006028; GABAA/Glycine_rcpt.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR PANTHER; PTHR18945:SF819; PH-SENSITIVE CHLORIDE CHANNEL 1, ISOFORM N; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00253; GABAARECEPTR.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 741..764
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 805..824
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 926..947
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 548..731
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DOMAIN 748..853
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
FT REGION 53..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 337..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..354
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..379
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 951 AA; 107169 MW; 90F40579DD4BBD03 CRC64;
MGCSFETAIQ TSGINETFDT ACLATIVEPA FRTRNFYARE STTALVPGNN NCITHNNKNN
NNSSSYNTKN NSICNHYNPK QDKTNDDCQL QQKPAKAKKT TTTNNNITST ITTTATNVKD
TNSSSNNNSR DEFKGKTNFY SLEVKENINN NCRSRSPNFL PVQERETLPE SCPSCYPLAC
HNRICCRQQS LFVSEIATQP RYCFDYLSCN CCNNNVNNCN CKCPCPGLVS SFVCQKHKNT
FRNECHDKKY AYLDRTPDSM SQQLDSCNNS SSMEGKCWQN TVSHASVALT SNALDLKNSL
TEAIGNCAAM VETLMRTTDE QCRKHCAAFE QCSSMNSNHI NNNTNNNNKS EPYRGYCQRK
QGSQPEHIPY TSTNSSRSLH DAISSKYHPH HHHHHQQCTR QQQCGSSNNN NKVSIANICS
NASNSRSSCS NCHAASPASR ASTQTAAFNY IGHNYYHFLR NSINFYTAYT ASIILVLCYL
TTTTSAATPK SDATSLDKHP IFDESSSDKE ILDLLLEQKR YDKRLLPPVH DEDFCCGLSS
PDMATEQNSR RPHKRGTLNV NVTVLLLSLA SPDESSLKYE VEFLLNQFWV DPRLQYGNKS
HYDFLNALHH HDSIWTPDTY FSMHGDFKDP IIPMHFALRI FRNGTIMYSM RRHLILSCQG
SLHIFPFDDP KCTFSMESIS YEEPQIRYVW RNGEVTLLKS PSLTTLNAYL IKNQTTACDQ
HSWRGNYSCL QVDLTFTRDR AYYFTTVFIP GIILVTSSFI TFWLEWNAVP ARVMIGVTTM
LNFFTTSNGF RSTLPVVSNL TAMNVWDGVC MCFIYASLLE FVCVNYMGRK RPQHNVVYRP
GENPVTQRLP AVLSRIGVIL ASPLPGEKKR DTGGPNEIVA CTTCGGNSGT PCTHSANNGC
ATETCFVQVR KKEPPHPIRI AKTIDVIARI TFPTAYAIFL IFFFVHYKGF S
//
