ID A0A1I8NG81_MUSDO Unreviewed; 1058 AA.
AC A0A1I8NG81;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA014809-PB};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA014809-PB}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA014809-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR AlphaFoldDB; A0A1I8NG81; -.
DR SMR; A0A1I8NG81; -.
DR STRING; 7370.A0A1I8NG81; -.
DR EnsemblMetazoa; MDOA014809-RB; MDOA014809-PB; MDOA014809.
DR VEuPathDB; VectorBase:MDOA014809; -.
DR eggNOG; KOG2301; Eukaryota.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 2.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 2.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF288; SODIUM CHANNEL PROTEIN; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR PRINTS; PR00170; NACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU361132};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 12..29
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 49..72
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 321..340
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 347..370
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 474..500
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 561..578
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 624..643
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 687..711
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 772..796
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
SQ SEQUENCE 1058 AA; 119404 MW; 03D0A38D1853F371 CRC64;
HKDRFKDHEL PRWNFTDFMH SFMIVFRVLC GEWIESMWDC MYVGDVSCIP FFLATVVIGN
LVVLNLFLAL LLSNFGSSSL SAPTADNDTN KIAEAFNRIA RFKNWVKRNI ADCFKLIRNK
LTNQISDQPS INKKRKKMIG NSINHQDNRL EHELNHRGLS IQDDDTASIN SYGSHKNRPF
KDESHKGSAE TIEGEEKRDV SKEDLGLDEE LDEEAEGDEG QLDGDIIIHA QNDDEIIDDY
PADCFPDSYY KKFPILAGDE DSPFWQGWGN LRLKTFQLIE NKYFETAVIT MILMSSLALA
LEDVHLPDRP VMQDILYYMD RIFTVIFFLE MLIKWLALGF KVYFTNAWCW LDFVIVMLSL
INLVAVWSGL NDIAVFRSMR TLRALRPLRA VSRWEGMKCK DGNDTVLSHE IIPNRNACKS
ENYTWENSAM NFDHVGNAYL CLFQVATFKG WIQIMNDAID SREVDKQPIR ETNIYMYLYF
VFFIIFGSFF TLNLFIGVII DNFNEQKKKA GGSLEMFMTE DQKKYYNAMK KMGSKKPLKA
IPRPRWRPQA IVFEIVTDKK FDIIIMLFIG LNMFTMTLDR YDASEAYNNV LDKLNGIFVV
IFSGECLLKI FALRYHYFKE PWNLFDVVVV ILSILGLVLS DIIEKYFVSP TLLRVVRVAK
VGRVLRLVKG AKGIRTLLFA LAMSLPALFN ICLLLFLVMF IFAIFGMSFF MHVKEKSGIN
AVYNFKTFGQ SMILLFQMST SAGWDGVLDA IINEEDCDPP DNDKGYPGNC GSATVGITFL
LSYLVISFLI VINMYIAVIL ENYSQATEDV QEGLTDDDYD MYYEIWQQFD PEGTQYIRYD
QLSEFLDVLE PPLQIHKPNK YKIISMDMPI CRGDMMYCVD ILDALTKDFF ARKGNPIEET
GEIGEIAARP DTEGYDPVSS TLWRQREEYC AKLIQNAWRR YKNGPPQEGD EGEAAGGEDG
AEGGEGEGGS GGGGGDDGGS ATGATAAAAG ATSPSDPDAG EADGASVGGP LSPGCVSGGS
NGRQTAVLVE SDGFVTKNGH KVVIHSRSPS ITSRTADV
//
