ID A0A1I8NHG6_MUSDO Unreviewed; 193 AA.
AC A0A1I8NHG6;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Peptidoglycan-recognition protein {ECO:0000256|PIRNR:PIRNR037945};
GN Name=101895074 {ECO:0000313|EnsemblMetazoa:MDOA015190-PA};
GN Synonyms=LOC101895074 {ECO:0000313|RefSeq:XP_005180889.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA015190-PA};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA015190-PA}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA015190-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005180889.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_005180889.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
CC {ECO:0000256|ARBA:ARBA00007553, ECO:0000256|PIRNR:PIRNR037945}.
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DR RefSeq; XP_005180889.1; XM_005180832.3.
DR STRING; 7370.A0A1I8NHG6; -.
DR EnsemblMetazoa; MDOA015190-RA; MDOA015190-PA; MDOA015190.
DR VEuPathDB; VectorBase:MDOA015190; -.
DR eggNOG; ENOG502QR3D; Eukaryota.
DR OrthoDB; 2282228at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0008745; F:N-acetylmuramoyl-L-alanine amidase activity; IEA:InterPro.
DR GO; GO:0042834; F:peptidoglycan binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0009253; P:peptidoglycan catabolic process; IEA:InterPro.
DR CDD; cd06583; PGRP; 1.
DR Gene3D; 3.40.80.10; Peptidoglycan recognition protein-like; 1.
DR InterPro; IPR036505; Amidase/PGRP_sf.
DR InterPro; IPR002502; Amidase_domain.
DR InterPro; IPR017331; Peptidoglycan_recognition.
DR InterPro; IPR015510; PGRP.
DR InterPro; IPR006619; PGRP_domain_met/bac.
DR PANTHER; PTHR11022; PEPTIDOGLYCAN RECOGNITION PROTEIN; 1.
DR PANTHER; PTHR11022:SF75; PEPTIDOGLYCAN-RECOGNITION PROTEIN LB-RELATED; 1.
DR Pfam; PF01510; Amidase_2; 1.
DR PIRSF; PIRSF037945; PGRPs; 1.
DR SMART; SM00644; Ami_2; 1.
DR SMART; SM00701; PGRP; 1.
DR SUPFAM; SSF55846; N-acetylmuramoyl-L-alanine amidase-like; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859, ECO:0000256|PIRNR:PIRNR037945};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588,
KW ECO:0000256|PIRNR:PIRNR037945};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..193
FT /note="Peptidoglycan-recognition protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041120722"
FT DOMAIN 20..163
FT /note="Peptidoglycan recognition protein family"
FT /evidence="ECO:0000259|SMART:SM00701"
FT DOMAIN 31..169
FT /note="N-acetylmuramoyl-L-alanine amidase"
FT /evidence="ECO:0000259|SMART:SM00644"
FT DISULFID 57..63
FT /evidence="ECO:0000256|PIRSR:PIRSR037945-1"
SQ SEQUENCE 193 AA; 21604 MW; A89D2D22B5E89DA9 CRC64;
MTALGLVLLS MMGFSQQMKS GMVTRDEWGA RSPTMIETFQ GPAPFVIIHH SYQPEACFTN
KDCRKAMRVM QDYHQLTHGW NDIGYSFAVG GDGMIYMGRG FNVVGAHAPK YNDKSVGICL
IGDWRTELPP PQMLKAAKDL IAFGVAKGYI HPDFKLMGHR QVRDTECPGG RLFNEISTWD
HFSPGNTTEN EIK
//
