ID A0A1I8NIJ7_MUSDO Unreviewed; 637 AA.
AC A0A1I8NIJ7;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Nuclear protein localization protein 4 homolog isoform X2 {ECO:0000313|RefSeq:XP_005180042.1};
GN Name=101887729 {ECO:0000313|EnsemblMetazoa:MDOA015524-PA};
GN Synonyms=LOC101887729 {ECO:0000313|RefSeq:XP_005180042.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EnsemblMetazoa:MDOA015524-PA};
RN [1] {ECO:0000313|EnsemblMetazoa:MDOA015524-PA}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|EnsemblMetazoa:MDOA015524-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_005180042.1}
RP IDENTIFICATION.
RC STRAIN=Aabys {ECO:0000313|RefSeq:XP_005180042.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NPL4 family.
CC {ECO:0000256|ARBA:ARBA00011025}.
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DR RefSeq; XP_005180042.1; XM_005179985.3.
DR EnsemblMetazoa; MDOA015524-RA; MDOA015524-PA; MDOA015524.
DR GeneID; 101887729; -.
DR VEuPathDB; VectorBase:MDOA015524; -.
DR OrthoDB; 5400828at2759; -.
DR Proteomes; UP000095301; Unassembled WGS sequence.
DR Proteomes; UP000694905; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR CDD; cd08061; MPN_NPL4; 1.
DR Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR InterPro; IPR037518; MPN.
DR InterPro; IPR016563; Npl4.
DR InterPro; IPR007717; NPL4_C.
DR InterPro; IPR024682; Npl4_Ub-like_dom.
DR InterPro; IPR007716; NPL4_Zn-bd_put.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR001876; Znf_RanBP2.
DR InterPro; IPR036443; Znf_RanBP2_sf.
DR PANTHER; PTHR12710; NUCLEAR PROTEIN LOCALIZATION 4; 1.
DR PANTHER; PTHR12710:SF0; NUCLEAR PROTEIN LOCALIZATION PROTEIN 4 HOMOLOG; 1.
DR Pfam; PF05021; NPL4; 1.
DR Pfam; PF11543; UN_NPL4; 1.
DR Pfam; PF05020; zf-NPL4; 1.
DR PIRSF; PIRSF010052; Polyub_prc_Npl4; 1.
DR SMART; SM00547; ZnF_RBZ; 1.
DR SUPFAM; SSF90209; Ran binding protein zinc finger-like; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50249; MPN; 1.
DR PROSITE; PS01358; ZF_RANBP2_1; 1.
DR PROSITE; PS50199; ZF_RANBP2_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000694905};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00322};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00322}.
FT DOMAIN 239..376
FT /note="MPN"
FT /evidence="ECO:0000259|PROSITE:PS50249"
FT DOMAIN 609..637
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT REGION 574..606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 637 AA; 71667 MW; 225B2C4A77B34D12 CRC64;
MSKPGQNILV RVQSPEGIKR IEISPKANLK DLFESVQKAL KVDGFGLFKE RNLTKEIYSH
TSQEVGSVLK HGDMIYLKQM AGTSSRRTST TAIDNFTSAK AITNSATTTN SSDFKPSAAV
KEDEVDILLA KEDGLIKRER DSKLCRHAAN GCCVHCSPLE PYNENYLKEQ KIKHLSFNSY
IRKQTSGIDR GKYMVFEDIN CRIKPGCREH PPWPRGICSK CQPSAITLNR QIYRHVDNVM
FENTTIVERF LNYWRTTGHQ RMGFLYGTYE VNTDVPLGIR AKVAAIYEPP QESSRDSIRL
LNDENAEDVE EVAKALGLKK VGWIFTDLIT DDPAAGTVKH IRGIETHFLT AQECIMAGEL
QNRHPNPCKY ASNGVFGSKF VTVCVTGDNT KQVHMEGYAV SAQCMALVRD NCLLPTKDAP
ELGYVRESTD KQYVPDVYYK EKDQYGNEVQ RLARPLPVEY LLVDVPASTP LQPQFTFSKY
DKRQPFPVEN RYLDGHLQDF NALSAYLSQW DDEDFLEAIS DFHLLVYLYK MDMLPMRQHM
MPLLEAVRNK NPNMAYAFKK EEVWKLLESL IQASSSGSGG TTSYPSASST NRTGAGGGSS
SNAMESSGID GNTWTCNHCT FINRSELSSC EICSLPR
//
