ID A0A1I8NLX6_STOCA Unreviewed; 924 AA.
AC A0A1I8NLX6;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=106081787 {ECO:0000313|EnsemblMetazoa:SCAU000168-PB};
OS Stomoxys calcitrans (Stable fly) (Conops calcitrans).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Stomoxys.
OX NCBI_TaxID=35570 {ECO:0000313|EnsemblMetazoa:SCAU000168-PB, ECO:0000313|Proteomes:UP000095300};
RN [1] {ECO:0000313|EnsemblMetazoa:SCAU000168-PB}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:SCAU000168-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR RefSeq; XP_013099444.1; XM_013243990.1.
DR AlphaFoldDB; A0A1I8NLX6; -.
DR EnsemblMetazoa; SCAU000168-RB; SCAU000168-PB; SCAU000168.
DR VEuPathDB; VectorBase:SCAU000168; -.
DR OrthoDB; 460351at2759; -.
DR Proteomes; UP000095300; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd01093; CRIB_PAK_like; 1.
DR CDD; cd06647; STKc_PAK_I; 1.
DR Gene3D; 3.90.810.10; CRIB domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR000095; CRIB_dom.
DR InterPro; IPR036936; CRIB_dom_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR033923; PAK_BD.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR48015; SERINE/THREONINE-PROTEIN KINASE TAO; 1.
DR PANTHER; PTHR48015:SF35; SERINE_THREONINE-PROTEIN KINASE PAK; 1.
DR Pfam; PF00786; PBD; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00285; PBD; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50108; CRIB; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}.
FT DOMAIN 74..87
FT /note="CRIB"
FT /evidence="ECO:0000259|PROSITE:PS50108"
FT DOMAIN 650..901
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 150..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 195..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 604..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..55
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..215
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..251
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..299
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 604..622
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 679
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 924 AA; 98457 MW; 1327A0DDE0687753 CRC64;
MSSEEDKPPA PPVRLTSNRG GDRVGGPIAG SGDGPPVDMR PLPKEPDDPD RKKKTLKNKI
KGSKPSHQDS KPNISYPTNF EHTVHVGFDA VTGEFTGMPE AWARLLMNSN ISKQEQKKNP
QAVLDVLKWF DNTTKQRPSS KYMTNAITTH SGSSLSRVSS SSPSSTPTDS ELHGSNSGGN
LIGVNIGSLN IGGGGSGSNS SSAGGLNSSG GLVTSGGLVG NHHTPPHHHH HQQAQQQQQS
HHHHHHQQSP HAAALHHQSP QQQQQHQQHA TISQSHSYNF GGNTASSSSQ HSSANEDDIL
GTPQPPPPPI ASRPERTKSI YTRPIEDVVP QPAVTPIIPP PTAAPATTPT TPQHNNVAQP
QFKTPTHAVA ANSTLDKNKN NATPTTAAGY YEADLISTAL ETDPSTATTT TNLNLLTTTC
TTTTTTPTTT TAAAASAAVA TSLNATPSTS NQLQFIDCNA TTTTTNHDSS ASSFSSFPSY
HDDMTTLPPI YCPSSSSSYI DSVTMPTPPL PTPTATIHHQ STLGVDANDG AAPVACAVST
ITTITPATPD ATYHHGAVIA PSSTPTVTIT DLYANDANTN NLTAGSAAAV AAAVPTPIAT
AATVTPTTGT TTTTTTQQRS GAAKKKKMSD EEILEKLRTI VSVGDPNRKY TKMEKIGQGA
SGTVYTAIES STGMEVAIKQ MNLSQQPKKE LIINEILVMR ENKHPNVVNY LDSYLVSEEL
WVVMEYLPGG SLTDVVTETC MDEGQIAAVC REVLQALEFL HSNQVIHRDI KSDNILLGLD
GSVKLTDFGF CAQISPEQSK RTTMVGTPYW MAPEVVTRKQ YGPKVDLWSL GIMAIEMVEG
EPPYLNENPL KALYLIATNG KPEIKEKEKL STVFQDFLDQ CLEVEVDRRA SAMELLKHPF
LKLARPLASL TPLIMAAKEA TKGN
//
