ID A0A1I8NMK6_STOCA Unreviewed; 845 AA.
AC A0A1I8NMK6;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Ecdysone receptor {ECO:0000256|ARBA:ARBA00022052};
DE AltName: Full=20-hydroxy-ecdysone receptor {ECO:0000256|ARBA:ARBA00029963};
DE AltName: Full=EcRH {ECO:0000256|ARBA:ARBA00030794};
DE AltName: Full=Ecdysteroid receptor {ECO:0000256|ARBA:ARBA00033003};
DE AltName: Full=Nuclear receptor subfamily 1 group H member 1 {ECO:0000256|ARBA:ARBA00033286};
GN Name=106096274 {ECO:0000313|EnsemblMetazoa:SCAU000354-PA};
OS Stomoxys calcitrans (Stable fly) (Conops calcitrans).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Stomoxys.
OX NCBI_TaxID=35570 {ECO:0000313|EnsemblMetazoa:SCAU000354-PA, ECO:0000313|Proteomes:UP000095300};
RN [1] {ECO:0000313|EnsemblMetazoa:SCAU000354-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:SCAU000354-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC subfamily. {ECO:0000256|ARBA:ARBA00008092}.
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DR RefSeq; XP_013119381.1; XM_013263927.1.
DR AlphaFoldDB; A0A1I8NMK6; -.
DR SMR; A0A1I8NMK6; -.
DR STRING; 35570.A0A1I8NMK6; -.
DR EnsemblMetazoa; SCAU000354-RA; SCAU000354-PA; SCAU000354.
DR GeneID; 106096274; -.
DR KEGG; scac:106096274; -.
DR VEuPathDB; VectorBase:SCAU000354; -.
DR OrthoDB; 5390715at2759; -.
DR Proteomes; UP000095300; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0035100; F:ecdysone binding; IEA:InterPro.
DR GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0035076; P:ecdysone receptor-mediated signaling pathway; IEA:InterPro.
DR CDD; cd07161; NR_DBD_EcR; 1.
DR CDD; cd06938; NR_LBD_EcR; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR003069; Ecdystd_rcpt.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR041889; NR_LBD_EcR.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR24082; NUCLEAR HORMONE RECEPTOR; 1.
DR PANTHER; PTHR24082:SF331; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP H, MEMBER 4-RELATED; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR01283; ECDYSTEROIDR.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 380..455
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 526..761
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT REGION 14..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 294..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 334..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 804..845
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..321
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 845 AA; 91195 MW; FE8FA928DCC8C3DF CRC64;
MNLSSMMYRL NHAQGQKLSL PSEQQQQQQQ QQPTSHPHQQ QAHQQQAIPS HILLQQQLDA
AATSAAVAAN STAGDNNVFL ANFAGNSSAE TDNASSSNSS NVVHSTPARN LIHLQPQQQQ
HVGARQLNNN LSNIVISSVD SLASASVEEK LKLLKTAIKS EPVHDISSQG SNLSSVAVLN
NHCKEELISL AACSALANIA PVASATSSSA SASSLTSAIK GNSLALKTPA GIVANAISNP
TATSQVTITA ASGSSGSSSG NGNTSVVDAA AANGSMASFV PSKRARLELR EEWISTPSPG
SVPSTAPLSP SSASQNHMYG ANLSNGYSSP MSAGSYDPFS PNGKQGRDDL SPSSSLNGFS
TSDASDVKKI KKGPAPRLQE ELCLVCGDRA SGYHYNALTC EGCKGFFRRS VTKNAVYCCK
FGHACEMDMY MRRKCQECRL KKCLAVGMRP ECVVPENQCA MKRLEKKAQK QKDKLQTNVC
ATDGVKKEIL LDLMSCEPPT HPTCPLLPED ILTKCQARNI PPLTYNQLAV IYKLIWYQDG
YEQPSEEDLK RIMSSPDENE SQTDVSFRHI TEITILTVQL IVEFAKGLPA FTKIPQEDQI
TLLKACSSEV MMLRMARRYD HNTDSIFFAN NRSYTRDSYK MAGMADNIED LLHFCRQMYS
MKVDNVEYAL LTAIVIFSDR PGLEEAELVE AIQSYYIDTL RIYILNRHCG DPMSLVFFAK
LLSILTELRT LGNQNAEMCF SLKLKNRKLP KFLEEIWDVH AIPPSVQSHI QATQAEKAAQ
EVLASTSGIA TAIQQVAATS SSSINTSLAT SSTSPTTAAS STPNGGGDFG TDMSLTLTGQ
TDSSA
//
