ID A0A1I8NNV9_STOCA Unreviewed; 1400 AA.
AC A0A1I8NNV9;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=Active breakpoint cluster region-related protein {ECO:0008006|Google:ProtNLM};
GN Name=106083002 {ECO:0000313|EnsemblMetazoa:SCAU000728-PC};
OS Stomoxys calcitrans (Stable fly) (Conops calcitrans).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Stomoxys.
OX NCBI_TaxID=35570 {ECO:0000313|EnsemblMetazoa:SCAU000728-PC, ECO:0000313|Proteomes:UP000095300};
RN [1] {ECO:0000313|EnsemblMetazoa:SCAU000728-PC}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:SCAU000728-PC};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}. Cell projection, dendritic spine
CC {ECO:0000256|ARBA:ARBA00004552}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
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DR RefSeq; XP_013101249.1; XM_013245795.1.
DR EnsemblMetazoa; SCAU000728-RC; SCAU000728-PC; SCAU000728.
DR GeneID; 106083002; -.
DR VEuPathDB; VectorBase:SCAU000728; -.
DR OrthoDB; 2916231at2759; -.
DR Proteomes; UP000095300; Unassembled WGS sequence.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13368; PH_BCR_arthropod; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 4.10.280.30; Bcr-Abl oncoprotein oligomerisation domain; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR037769; Abr/Bcr.
DR InterPro; IPR036481; Bcr-Abl_oncoprot_oligo_sf.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23182; BREAKPOINT CLUSTER REGION PROTEIN BCR; 1.
DR PANTHER; PTHR23182:SF1; RHO GTPASE ACTIVATING PROTEIN AT 1A, ISOFORM E; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF19057; PH_19; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658}.
FT DOMAIN 655..843
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 857..1018
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1047..1164
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1195..1394
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 67..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 226..376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 393..502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 25..52
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 75..93
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..160
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..183
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..276
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..345
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 393..407
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..482
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1400 AA; 155559 MW; 1458EB822DE5F044 CRC64;
MSVFNDFQRL WMERFPQSSL SDAWEQDVRA SLERHKSKIN ELTKELEQET MYVEYLERLL
SDVEKYRESG GDPTSLFEAA TNVDNSAGDS KSASDDLETG GDDFAADRSS KSSLNLRESK
NGTKEQNNRL SLNTDNKYTG TSGSSGKNGK NNLPPSSTSS EERTSEKEDK DVGTEKGKRN
NDENGALHQC ISELAASIAS NEDSTAAEKP SKSTSHFVTV IEVKESKINM DQNNPSLSMD
QGSDVGADHI PSTFSSFERK PSAPPLSPSM SSSAHAAALL EANKKKMPPR PPPKNIRRVE
PPTIPGTLLS SSPKRDSAFA GSSIPLPSSS GSLSSSDSPA NSLERNVKPS DILRQKSSES
MEGKTFSQNR KTTPDMNKFM NTTELLEELG QKISKTESLE KTKRPELSYS HSPTGSLGRT
GPNVQSVPGV NRSTQGRPGG HPLTGSSPTS SMNKNAKLTT ADNSSTGSLD KKSRTSLQPG
DADASIGQGR NVGSKESLSS QGISEIIKSY ESVSSLSSES VRANQMTESE QEHLYDTVPL
DNGDDEYVYI KPDRAGSFSS RDDLSTPGSV IPMSSNIHLS SQASFTDPES PGRSANYVNF
GCFTQENNET RSSSMDSDGE YENGMPIMRT ISHEEHNTPA PGALRKVSGN QRGNKIRTIL
NSIIQSETIY VACLNTMIQY KKAIHATLAT SQPVIKEEEE NTIFFMIEKL YESHSLFLSD
LKTLVAHEGG DVLIGETFKR LSEMVDLYSA FLHNYNQAID TVKKCSANNP QFKKIVATIV
LNLQTEQSLT LEDLLHKPVA RVQINALVFN DLLECTPPNH PDHHPLRHAH DTIHKFLKQF
NVVNQKLPTE SNKNLRRMVK NSFIVELVDG HRKLRHLFLF NDVIACAKYK ASGRDRIDYE
LKWFIALKDV AVFEETDGAA DLKESSPPNI LQLKTQACTV RDQLLMEEKD DKSRKANGLR
YGDKYRRKLA DLESQLVLAS PNLVFRIGNK ATNKSVTFFL SSDFERTQWI ESILSLQQTC
NIPGASSINA LEVHAFIVAM QKSMKTEMGS YLMRNTNDES LLVGDLHMTV QSLTGLENPA
DLYIIIEVDS YGHYFRKAGT KMICRTINPV WNESFVVELE GSQNVRILLY ALQERPILKS
KHVLKLSRSW LKETPQSRVV KLGDNLILNT ILHFVPGEVT LRRVPTSKPG ALFGAKMQQV
LKREKRDIPF IISACIREVE KRGMSEVGIY RVSGSASDLA KLKKSFETNP YEAEQLLKDV
DIHSVTGILK SYLRELPEAL FPDVLYPKFF ETFSRFTNNN EAERISVLLV VFEELPPANK
ASINHILDHL IRVHNREADN KMSLHNLAMV FGPTLLRPGA TQTKQKDLLA SSTVDVMAQA
GILYCFLQAR MQYERDSTNP
//
