ID A0A1I8NSM4_STOCA Unreviewed; 785 AA.
AC A0A1I8NSM4;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=carnitine O-palmitoyltransferase {ECO:0000256|ARBA:ARBA00013243};
DE EC=2.3.1.21 {ECO:0000256|ARBA:ARBA00013243};
GN Name=106096031 {ECO:0000313|EnsemblMetazoa:SCAU001666-PB};
OS Stomoxys calcitrans (Stable fly) (Conops calcitrans).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Stomoxys.
OX NCBI_TaxID=35570 {ECO:0000313|EnsemblMetazoa:SCAU001666-PB, ECO:0000313|Proteomes:UP000095300};
RN [1] {ECO:0000313|EnsemblMetazoa:SCAU001666-PB}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:SCAU001666-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC outer membrane {ECO:0000256|ARBA:ARBA00004374}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004374}.
CC -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005232}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_013119002.1; XM_013263548.1.
DR AlphaFoldDB; A0A1I8NSM4; -.
DR EnsemblMetazoa; SCAU001666-RB; SCAU001666-PB; SCAU001666.
DR GeneID; 106096031; -.
DR VEuPathDB; VectorBase:SCAU001666; -.
DR OrthoDB; 1429709at2759; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000095300; Unassembled WGS sequence.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004095; F:carnitine O-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR Gene3D; 6.10.250.1760; -; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR InterPro; IPR000542; Carn_acyl_trans.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR039551; Cho/carn_acyl_trans.
DR InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR InterPro; IPR032476; CPT_N.
DR PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR22589:SF31; CARNITINE O-PALMITOYLTRANSFERASE; 1.
DR Pfam; PF00755; Carn_acyltransf; 1.
DR Pfam; PF16484; CPT_N; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00022787};
KW Transferase {ECO:0000256|ARBA:ARBA00023315};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 55..76
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 96..122
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..45
FT /note="Carnitine O-palmitoyltransferase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16484"
FT DOMAIN 175..750
FT /note="Choline/carnitine acyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00755"
FT REGION 764..785
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 770..785
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 471
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ SEQUENCE 785 AA; 89749 MW; CEB92A04DB8445A0 CRC64;
MAEAHQAVAF SFAITHEGFD INYDQEVLNL VWNSGFRSWK KRVARARNGV RNGVYPAHIQ
SLWLITAIAL GLHFAGLRTP FNIVNRILVN LPANTINWQV TACFLASLVI WLSICFTMRY
TLKLLLMYKG WMYESRAPGS KTSLRTKLWA GAVKVFSSWN KPGLYSFQGS LPRLTLPSVT
ATTQRYLRSV RPLLDDEKYK RMEGLAHEFE TTIGKKLQWY LILKSWWSTN YVSDWWEEYV
YLRGRSPLMI NSNFYGTDAI FMDLSHNQAA RAANVVYLLL GFRRLIERQE LQPIMVQGIV
PLCSWQYERT FNTVRVPGME TDRIVHYRDS NHIVVLHKGC YYKVLIYYKG RQLRPCEIQV
QMEEILNSKA TPLPGEEHLA ALTAWNRSKW AEVRNTYFTR GVNRVSLHTV ESAAFVVSLD
DIPFEFDLNR PELLDNFGKT LLHGNGYNRW FDKSFTVCVG TNGRVGFNAE HTWADAPVMG
HTWEYIFGDE IDGYDENGNT RGTPEFQPPS PTRLSWKLEP CLTQIEEATL DANKLINDID
LRILVHNQYG KGFMKKCRLS PDAFIQMALQ LAYYRDAGRF SLTYEASMTR LFREGRTETV
RPCTIESAAW VKAMEDKTKT NDERVALIKA ACDRHQLGYQ DAMCGHGIDR HLFCLYVVSK
YLEVDSPFLN EVLSEPWRLS TSQTPHGQTP KMDLKKHPQC ISSGGGFGPV ADDGYGVSYI
IAGEDLIFFH ISAKNSCDTT NVHRFADNIC KALADIRSMF EEHMKKNPPK SKAVSSNGNQ
ASASK
//