ID   A0A1I8NUJ8_STOCA        Unreviewed;       905 AA.
AC   A0A1I8NUJ8;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   08-NOV-2023, entry version 33.
DE   RecName: Full=Phorbol-ester/DAG-type domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   Name=106080706 {ECO:0000313|EnsemblMetazoa:SCAU002153-PJ};
OS   Stomoxys calcitrans (Stable fly) (Conops calcitrans).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC   Muscidae; Stomoxys.
OX   NCBI_TaxID=35570 {ECO:0000313|EnsemblMetazoa:SCAU002153-PJ, ECO:0000313|Proteomes:UP000095300};
RN   [1] {ECO:0000313|EnsemblMetazoa:SCAU002153-PJ}
RP   IDENTIFICATION.
RC   STRAIN=USDA {ECO:0000313|EnsemblMetazoa:SCAU002153-PJ};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
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DR   RefSeq; XP_013097647.1; XM_013242193.1.
DR   AlphaFoldDB; A0A1I8NUJ8; -.
DR   EnsemblMetazoa; SCAU002153-RJ; SCAU002153-PJ; SCAU002153.
DR   GeneID; 106080706; -.
DR   VEuPathDB; VectorBase:SCAU002153; -.
DR   OrthoDB; 2916730at2759; -.
DR   Proteomes; UP000095300; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd20831; C1_dGM13116p-like; 1.
DR   CDD; cd08678; C2_C21orf25-like; 1.
DR   Gene3D; 3.30.60.20; -; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   InterPro; IPR046349; C1-like_sf.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR039934; C2CD2/C2CD2L.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   PANTHER; PTHR21119:SF5; C2 DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR21119; UNCHARACTERIZED; 1.
DR   Pfam; PF00130; C1_1; 1.
DR   Pfam; PF00168; C2; 1.
DR   SMART; SM00109; C1; 1.
DR   SMART; SM00239; C2; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR   SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR   PROSITE; PS50004; C2; 1.
DR   PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   TRANSMEM        25..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          370..483
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          826..878
FT                   /note="Phorbol-ester/DAG-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50081"
FT   REGION          58..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          97..119
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          134..159
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          636..770
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        636..658
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        667..735
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        753..770
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   905 AA;  98573 MW;  816494574D5EC601 CRC64;
     MDLADQIDDY ICTFEGLGDI TMDSLAMFIF LWAVLALFLV WLCKFLYQKY MVKEKPVSAS
     NSRQSSVAPG GVAKTEKRLS EPRDILASKT EVKDLLSKPS AGGVGRGRTP GPAGFGGGAG
     GGGGIGIGGA GARRRVVRQS STGPENRKKR YVPPPSNVVG PETTSVTWTS QVFRWLYSDL
     VIVNELLMSW VIALNDTLRK TGDEQGVAVE IVRVLPDSPP PSLSNIFCNA DEANPADMLI
     TFDCDAMPVF QVKAFRQKSG KVEASHYKLT VSRFRARIAN AMNYNTLKGD LRVEGFPDIR
     ITMNSVGAIK PMDQEETQVQ AIISDMMTRA LRDTIYPVDF SIYTTCPRAE VEPLDLPVIY
     PMQYETVANN MDFGMGSHGA QSMVSGRRLL VKIVKGDGLK DAHDPYVVIE MDEPPQKNQT
     GARQGNQPYW DEHFLFDLSP QSAEILFEVY DRPADASGNP KFLGLGLVGI DELAVGPAST
     QVLALQPRPY ETQQVFGSIT VDFVFIEGAE IPAGPRPYKL KEALHISTPS INEHLRNGSN
     LADAAVRALQ EGALNTTNGQ PSKSTLIIHS VQRNSSNPNA FKVEINKDGQ IEVKESQDVL
     NAAVSKALDS TGELEANESL PLDSLENIEQ ITQDTSVTTD ITASPTDSYP QNECLNDKPS
     LDITAGNDSA LGDSTTEYGQ PNAASSPNGL NNYQLNGASS SMSGYSPANG QQSSYTNNGY
     NSNSLPRNGM MSQQPLASPA EDLDDRGRSR SGMSPTLDHS RRSSISESSA ISGFSSASTK
     TYVHEASTLV LETIENGIKR HFIVPLNIAQ RPRWRRKGTK LHIYNDHTFI AKHLSGGGLQ
     CSICMKSIPR RPGKQGYECR DCQLICHKQC HIRAPQACPN PTVLSMELAS FPVLTENDLH
     LVNIK
//