ID A0A1I8NW50_STOCA Unreviewed; 2161 AA.
AC A0A1I8NW50;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=AF4/FMR2 family member lilli {ECO:0000256|ARBA:ARBA00021888};
DE AltName: Full=Protein lilliputian {ECO:0000256|ARBA:ARBA00032149};
GN Name=106084721 {ECO:0000313|EnsemblMetazoa:SCAU002544-PE};
OS Stomoxys calcitrans (Stable fly) (Conops calcitrans).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Stomoxys.
OX NCBI_TaxID=35570 {ECO:0000313|EnsemblMetazoa:SCAU002544-PE, ECO:0000313|Proteomes:UP000095300};
RN [1] {ECO:0000313|EnsemblMetazoa:SCAU002544-PE}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:SCAU002544-PE};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- FUNCTION: Has a role in transcriptional regulation. Acts in parallel
CC with the Ras/MAPK and the PI3K/PKB pathways in the control of cell
CC identity and cellular growth. Essential for regulation of the
CC cytoskeleton and cell growth but not for cell proliferation or growth
CC rate. Required specifically for the microtubule-based basal transport
CC of lipid droplets. Plays a partially redundant function downstream of
CC Raf in cell fate specification in the developing eye. Pair-rule protein
CC that regulates embryonic cellularization, gastrulation and
CC segmentation. {ECO:0000256|ARBA:ARBA00024653}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the AF4 family. {ECO:0000256|ARBA:ARBA00007354}.
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DR RefSeq; XP_013104063.1; XM_013248609.1.
DR RefSeq; XP_013104065.1; XM_013248611.1.
DR RefSeq; XP_013104066.1; XM_013248612.1.
DR EnsemblMetazoa; SCAU002544-RA; SCAU002544-PA; SCAU002544.
DR EnsemblMetazoa; SCAU002544-RD; SCAU002544-PD; SCAU002544.
DR EnsemblMetazoa; SCAU002544-RE; SCAU002544-PE; SCAU002544.
DR VEuPathDB; VectorBase:SCAU002544; -.
DR OrthoDB; 4254515at2759; -.
DR Proteomes; UP000095300; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0007366; P:periodic partitioning by pair rule gene; IEA:UniProtKB-KW.
DR GO; GO:0010468; P:regulation of gene expression; IEA:InterPro.
DR Gene3D; 6.10.250.2670; -; 1.
DR InterPro; IPR007797; AF4/FMR2.
DR InterPro; IPR043640; AF4/FMR2_CHD.
DR PANTHER; PTHR10528; AF4/FMR2 FAMILY MEMBER; 1.
DR PANTHER; PTHR10528:SF17; AF4_FMR2 FAMILY MEMBER LILLI; 1.
DR Pfam; PF18876; AFF4_CHD; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Pair-rule protein {ECO:0000256|ARBA:ARBA00022788};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 1923..2157
FT /note="AF4/FMR2 C-terminal homology"
FT /evidence="ECO:0000259|Pfam:PF18876"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 104..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 304..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 399..552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 617..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 744..764
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 802..1055
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1068..1211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1240..1273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1293..1338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1441..1536
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1627..1718
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1753..1823
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2056..2084
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..143
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..231
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..356
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 515..552
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..650
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 880..903
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 911..948
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 966..1049
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1068..1165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1169..1193
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1194..1208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1240..1261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1296..1316
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1441..1479
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1480..1494
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1499..1513
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1632..1712
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1756..1823
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2161 AA; 231273 MW; E1CCD9C933746E0D CRC64;
MDDYEYERRQ RREREKSERQ QVQTSSSSNR EVALFPEPRR VNPSEDDDDI AAKLGDYSKV
KEYINLYTVG FNSAHRHMPA NAVLPGIVPT SPASSAVGAT SSSMAPITAS SSSRLLPPPL
SSQSQQPPHH YQQHQQQLRQ APYVKQADNK PPYNGRGGYP GQPVNRSSSG MAPPKGPPGS
SSSLLPPATT HMPNGRQTSS SSSSANEKSY LGPPAATTHN GRFSQPSVPK QRQKPAFPHE
ENDIKEIINH VTNKFRPPTM LTGIDATPHN TLMENYNLNE PNKHKYSFDI SAKGNMIEPL
LDSPPHIEMP APRRVPPLLS AAPSATQMPS TQSASSNSNS SSSASSCSSM SMPTSSSTYI
APLPPANASA LVSTNSNAIS TSSSSGQSSM LLSSMNNSAI TSSPTVPLSP LLGRPKDTGF
LKPFKSEKPT PPPLERQNNT VANDLELSES DDDRVKQNRS AVNSSDSSPS DSSESGSESS
KSENNQPVPQ TAQHHLQQQQ MTSALGPKKK IGGPGSATGS SSSSGLGSSA PPSGGSSSSS
SNKTPSPSNT TKWQLSTYFN KAPLHQTPTQ DVVSPSTTSV VNSVNSMNVA NINMPITLRG
GAQIIPEPPQ QLTNIKNESM LDENEEDVDD VESRSFRRSR STKKDAGKNE SFPHPGLAAT
TAAFPTRKTP ASLSVTPLSP MLTDIKKEAS TPHPSLVMGS NQQQMNDYLA MSSNQIKHET
MVIAGGHTTV TSYGVERFSN LSSDSNISDE GTRERLPVRG PGGTLQISGV PATITALPRS
PPIVQKAPIP NTVTMIPIGP LPSSPPSVVG GRSLGSAQPT PTRAKKPRKK PKQTQRTIMA
PDTSDEEQED MGKQRLASPT VAKTMTTPGG TKKGRGRPRK TPNQSGNLSS ASSASTSAKG
PTLTAKKDIN KKPSPASTTT PSKETSATAR RRMSRLSSTV QDTPTPITTT PVKPIPIVAA
AKIVPPTHIT SQSNETMLNT SDDSSSSSDS SSYSNSKSSS SSSDSEAEGT KNNATLGPIA
SSSSDDNDEM IGSKSAAAAQ NQKQSDPKTT IVAPKRIVKI FKSSLEDLST ASSTKANNIC
LSSSSSSESS ADDFRTTSSF NNNNQQVVSV TSTVAAAGNT GGGGSSSQRS VNQQSPYKVS
STLSSRSRKH TPCSSAFSSE SSGEDNSDSD LGEANKETNL KRDKPKSDKN KISTLTRIFK
TSNEGGAKKQ GQVVIVDQSE EQQQQQQQKH ISPALRSSQE NLASAHTPLQ STSTSHSPRL
TPGGHLRSPR SLPMQPLANQ VLTAGCMMAA ASHRTPDRAP FDRVTTSAER KLQQRIKTPT
RTPTRTPPTT RTPTPTPSAA VAAAAANSTA SSVANPPSVS PVAATAAATA LPARLPSSLI
CKIDLSRLLP IPVEWHANTY RLYGGQGQCG QQLTPASAGR TPIYDHETIL NADLQSCNSQ
MRLKSSAGGG CTGSGGSGNA TPKSTGNRTP LQTISNASER ELSHSRESLH EISKDIVNPG
RLSSRSTDGS IGGGGSTPKD LSAHLPPPGP PNGYSSAAAM ARGYASPSAL MSGKLGLSGV
KHEQIIKHEP DAPEYNTANC NETKFKTDAT STDPSLIKQE LLILKQDFKP SDLMNITDKA
TALCSPKDQM QLVDAKPRRK RSSSSSSSPY KEKKRKREKE RDKDKDRDKD KDRDREKDKE
REKEKEREKD KEMLVLDKDK AMVTDSFKPA KDSLDTEMIN ANGQTQKEDI HMMNQQFPPT
NHERLLPEKP MLQPQEQHEK SNSNNNNNIC SNNNNNSTNS TCNVSNTASP AHLQSSNTLT
TTTTTTTAVL PSPSSQPTTI MPPPSNVGLI SAITTPAPPT LITAASVAPQ AAAMPLAPPI
NTTSNASSSI YPPTSFAPAA ITSGGATAGT CNVAVPPTPQ VVYRYRSYFE RDDDAISDEF
SKDKDNNKFL QEAIQRKHAA DREQNTFNQV ALYLEAVVYF LLTGAAMEQH GRFEDPAWTI
YKDTLSLIKF ISSKFRHLQM SSASQHETHN KVAILSLRCQ SLISLKLYKL KRGFCRQVNN
VCTEFFKSGK GDIINGNTPS SISPSNSVGS QGSGSNTPPG KIVPQDIHSA LHQQNQFFNY
LASSHELWDQ ADRLVRQGNH TDFFIALDHE NGPLTLHSNV YEVFRYVQAG LKKLKDEMLI
Q
//