ID A0A1I8NW97_STOCA Unreviewed; 2569 AA.
AC A0A1I8NW97;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Tight junction protein ZO-1 {ECO:0008006|Google:ProtNLM};
GN Name=106086373 {ECO:0000313|EnsemblMetazoa:SCAU002562-PA};
OS Stomoxys calcitrans (Stable fly) (Conops calcitrans).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Stomoxys.
OX NCBI_TaxID=35570 {ECO:0000313|EnsemblMetazoa:SCAU002562-PA, ECO:0000313|Proteomes:UP000095300};
RN [1] {ECO:0000313|EnsemblMetazoa:SCAU002562-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:SCAU002562-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004413}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR RefSeq; XP_013106478.1; XM_013251024.1.
DR EnsemblMetazoa; SCAU002562-RA; SCAU002562-PA; SCAU002562.
DR GeneID; 106086373; -.
DR VEuPathDB; VectorBase:SCAU002562; -.
DR OrthoDB; 2904077at2759; -.
DR Proteomes; UP000095300; Unassembled WGS sequence.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 3.
DR CDD; cd11859; SH3_ZO; 1.
DR Gene3D; 2.30.42.10; -; 3.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR13865:SF28; POLYCHAETOID, ISOFORM O; 1.
DR PANTHER; PTHR13865; TIGHT JUNCTION PROTEIN; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00595; PDZ; 2.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF00791; ZU5; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 3.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 3.
DR PROSITE; PS51145; ZU5; 1.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 446..533
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 607..689
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 849..922
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1110..1211
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT DOMAIN 2436..2569
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 88..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 722..821
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1227..1318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1415..1706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1743..1822
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2012..2037
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2099..2155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2176..2247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2358..2398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 722..764
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 785..799
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1227..1273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1292..1317
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1513..1527
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1560..1574
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1577..1598
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1614..1665
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1674..1694
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1792..1812
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2183..2219
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2377..2398
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2569 AA; 282865 MW; 31CE2A09F1079768 CRC64;
MSDTPSNTTA AMSREEEEEE VRTLLERHQE RIRLDLGNTD LLAVLVKNSV LTQSEEDLLL
KPYNAAGQNS APSSVGVTKR KLSAVISNAS SGTTGSTGGS STASTTGAPA NSGGQLSRSA
SINEDHPPSV SGGGDNRSIT PSVVNLNPNS DSISDQYSTK EELSAADSYN DAELLRLQCS
TLIEIISKNG FEKFKQFCYA IENECPQLIE DLINDRLKSD GTFDEEKINE DKLQKEIDTI
EYIDKDKENE RNRRAVSYGG ITNSSSVTTL PRAAPRRMNL MKEPPPPPPP KPILLQQASV
QSTSTTTTTS TLSIPSKYPQ SEYNLIQKID STSTLTAPSQ YQPQNFYANT ASIATNGSGH
GGGGGSISNY SSLLCHSSST TSPLAVRKRE KLLHRFSDAA TLGRKLKKKK NNNRTCRSMT
EAIEMLADPV IEDEFFGDRT TWEYHTVSVT RVPGYGFGIA VSGGRDNPHF ANGDPSIAVS
DVLKGGPAED RLQVNDRIIS VNGVSLENVE YATAVQVLRD SGNTVTLVVK RRVPLNTVVT
NPQQQQQQQQ MHQHSHSMSN AGLNSMPPTN GINSMVVPPN SAAMSQPNSL NSSLVQGNGP
SMSQPIKVTL TKNSKKEDYG IVLGCRLFIK EISSKARDQL AANGYSLQEG DIITRIHNTN
CADTMSLKEA KKIIDGCKER LNLVALRDIT NQPAITVVNQ LNNSNAQGNI YAQHQPQLSN
CSNNLDDPYL NGGATYSSQN LYVQPPTRTS NNGPVNGLND EKSNLTPRGR SRGPIMEGVS
LQQLDRPVTP PNASSSRSRL DEPPRPPPPR GAASNGGEDF YSSRRQLYED ESLTRSRQSS
EPRFISFQKE GSVGIRLTGG NEAGIFVTAV QPGSPASLQG LTPGDKILKV NDMDMLGVTR
EEAVLFLLSL QDRIDLIVQY CKEEYDEVVN NQRGDSFHIK THFHCDNPSK GEMAFKAGDV
FRVIDTLHNG VVGSWQVLKI GRGHQEMQRG VIPNKSRAEE LATAQFNATK KEMNASESRG
NFFRRRRSTH RRSKSLSREN WDDVVFSDSI SKFPAYERVV LRHPGFVRPV VIFGPISDLA
REKLAKDYPD KFSTPLQDDD KTNNSKCRIV RLSNIRDVMD RGKHALLDIT PNAVDRLNYA
QFYPIVIFQK TDSKHVIKQL RQGMPKSAHK SSKKLLEQCQ KLERVWSHIF STHIVLNDEE
SWYRKLRDAI DLQQSGAVWM SETKIPFDHT TTTQPPPNRR QTMDTSKYGG YPSNSNLLNS
DPSTPSTRPQ SLYGINAPDL PPRIDRQSKP GPNDIVSPST TTNTPSRSNS SGGTLGRSAQ
ERLFGKAIVS DDVQAEYISR NAVNPNGVGA GDTMERHHAS LERQARLNAA QSKIPGTNAT
AAAIATPQQN GSSYDSVSSY DSYNASQLTM QNLGRLGPNA PDDLKSVPNA NAGRPLPPVG
MGSQPADYAR TTHDHRPYGG ANDLNRQSSP GRPPYHDMNA ARNIDPRNGT PQRPSNLGLE
GSPRKVETKT DYGKYSRNNS ASQADYNKIP KNPGMPHMVV PPPNVNGNMN GSAGPNGASG
PFKPVPPPKP KNYRPPLQNA GNGNGPNQWE NQEPGSPRSP NGFYYPPAPQ HHHYGQQTPG
SPHTNAANMQ PTYGSNNNYG PPNASSYPAA NGYNGNATSH HYNGGSGTGP YIAPHRGMPP
PIGNLPPPPH TPERPGLDLA GSREQRGSAF ELYRKPQIGT AGHHHNMSEL ESYDQQQIYE
DYYAMPPPQN PPPRSRSVPR YPHERPPHVQ DPNYYSYGGG QLPPPLPPSH PHHQHQHQQQ
QQHPQQQYYN ENDMPPPLPH KIKKKSVLKS PLTALKNAFM KSTRPLRRIN SLVDPDRKPS
KSALKRQNSM LERGMQRPYY PDEYPTYPAG FDDRYYGGRG RSVPASAMRG GGGGAGREQQ
YYDQLPPNAY GYPSPDVMNS TYQNLGEEDI YGHMGTVPGR EQRLAREHPP YDPYGFSDQD
DIYANRACID LERRQMEAAQ NRNGKRIVRR HSTTTADRAH GRRPHAAMAA SPQTNSYEQD
DIYQSKQGAY MLDNQRRAPN SEVMARRRFY PGAANEQAEI HEPVYQSRRE MQREMQRNHL
YQTKKEMQDR ISQGKREMER EFSPQSGSQS EKDDKSEKEP IYQSRRDMVK ESALKTRAQL
RDQIYQTRRE ALDSMAEPSY ISKRDMGRPE PIYETKEESI LQSRENETDE KKEGKTEINT
QAEINHVGGA AGSDRLSPSD LQKSSDTVIE MSAAEKSAPL AQNDEDDLEM GGVSKDFDRT
DMHTIIENKH NQGMLEQTDM EANETNDTQD ISDDVFEIPQ AVSSPLVVEG PPIEPLEPPK
PTLPLTPRSS RAPFHISNIL KRTGPPPLKK LSDSRTSIET HYTSQASLPV GPPNATSTPY
TSNMSLPIAG PVPTSAPAAA SLPGKGSFPT VPREPSTCRG IFDSNGGTLA DNVWNVSLHI
PPGAIAPGVR QEIYFTVSDP RMGQAVGGPP LDMENGETML SPLVMCGPQG LEFLTPVTLN
IPHCAGKTTS LGLALKATDS EKNIHTEWDN IDLPSNAAAH TVSVKVDHF
//
