ID A0A1I8NWK2_STOCA Unreviewed; 1134 AA.
AC A0A1I8NWK2;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=MHD domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=106087837 {ECO:0000313|EnsemblMetazoa:SCAU002645-PB};
OS Stomoxys calcitrans (Stable fly) (Conops calcitrans).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Stomoxys.
OX NCBI_TaxID=35570 {ECO:0000313|EnsemblMetazoa:SCAU002645-PB, ECO:0000313|Proteomes:UP000095300};
RN [1] {ECO:0000313|EnsemblMetazoa:SCAU002645-PB}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:SCAU002645-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane, clathrin-coated pit
CC {ECO:0000256|ARBA:ARBA00004283}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004283}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004283}.
CC -!- SIMILARITY: Belongs to the FCHO family.
CC {ECO:0000256|ARBA:ARBA00011064}.
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DR RefSeq; XP_013108491.1; XM_013253037.1.
DR AlphaFoldDB; A0A1I8NWK2; -.
DR EnsemblMetazoa; SCAU002645-RB; SCAU002645-PB; SCAU002645.
DR VEuPathDB; VectorBase:SCAU002645; -.
DR OrthoDB; 2996449at2759; -.
DR Proteomes; UP000095300; Unassembled WGS sequence.
DR GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
DR CDD; cd09265; AP_Syp1_like_MHD; 1.
DR CDD; cd07648; F-BAR_FCHO; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR028565; MHD.
DR InterPro; IPR018808; Muniscin_C.
DR PANTHER; PTHR23065:SF15; AT02057P; 1.
DR PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF10291; muHD; 1.
DR SMART; SM00055; FCH; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS51072; MHD; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077, ECO:0000256|SAM:Coils}.
FT DOMAIN 3..249
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 840..1108
FT /note="MHD"
FT /evidence="ECO:0000259|PROSITE:PS51072"
FT REGION 313..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 489..547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 582..614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 686..720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 754..794
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1111..1134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 100..182
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 313..401
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 411..426
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 442..470
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..538
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 582..609
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 686..715
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 754..781
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1118..1134
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1134 AA; 123545 MW; 045C90C57202AE6D CRC64;
MTVDFNDYFW GEKNNGFDVL YHNMKFGLQA SKELSDFFRE KSNIEEQNSK LMSKLAHKAS
TGTLNSTFAP IWTILRTSAE KLSTLHMQMV QKLSELVKDV AKYADELHKK QKAVKEDEAQ
TLECVKAIQT STSEVQKAKD LYSGKVQELE KLRKDNASQK DIEKLETKLR KLQEEYKLLL
DKHNPIKNEF ERRMTQTCKR FQEIEEVHLR QMKEFLSTYL ELLQNNHDMV GQVHSDFKRQ
FLDMTVDKLL EQFVLNKYTG LEKPEMPELE FIPLSINQQM LATSNVRLNQ PSITSNSNSV
TSINRGTSAY TTEQRAAEGM STGSLTSGSG GFANAEESTS EAKNTKPLSR PTSPECTSAN
PVATGVKSNF RNWFSSNSAS KPQQQSAGMP ASVTSGSGNF VERDTLMVDP AGDSTPTSSN
SRESKVRANA DGPLTAIKHH QCSPPQPITK SKNSTTTNIT PPSSSVLVTN QRRTTSLLNI
FTSNSQVSGI LRSRRDKAKT KKSKKKKDGE MADNIQEERT HSVDKGSNCG EYEENKLKTH
NSSGSSAGAL AISSNSGGGS VDSAGASAAA STSIIAGISN SAEVDLSRTK NSTSLSPAVG
QTSEGNEVDE DGYSIQPPKE VAWEENNENA GFYSDSDSDS DNDRPEKRIH VKIKPLNNGQ
APMSASVDEL RATVENISLS PTGIFTQHSQ QLQQQSRLPS RQQSPEISNA STPTAAVHPY
APLQSPTLSM THNSRYADLG DIFSELGEVS SSAPASANFG KSHGRQIPTP TSVTGSSIAI
PRPPSRRSEM VVGSRGRISP APINVMNRAD SIGSLEFRTA IGGIGSSRGP SPLTIGISDT
VPLAVAFHEI IHAYFRGSDE SRCQVKISGD MMLSFPAGIA GLLANNPNPA KLGFRIKNVH
NLENFIPNSK LVQVDKNQSS SFSTMLEFNM SALTALLRRQ AEHNPTASYF NVDILKYQVR
TKPGASSCPF QLVTYWKCEP TFTALKVDYK YNNHAMVAAC PLLNVTLSVP VNGAVRNVQS
KPHSAWLGES NRLVWNFTDI SQNSQDGGVG TLRARLELGD GPSTPTLLST QFNCEGTTLS
GIEFELQGAG YRVSLVKKRF VSGKYVCEGD GIRSAATPTP PSVGSSSPFS AKSN
//
