ID A0A1I8NY36_STOCA Unreviewed; 884 AA.
AC A0A1I8NY36;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=DNA replication licensing factor MCM2 {ECO:0000256|ARBA:ARBA00018925};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=106080416 {ECO:0000313|EnsemblMetazoa:SCAU003099-PA};
OS Stomoxys calcitrans (Stable fly) (Conops calcitrans).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Stomoxys.
OX NCBI_TaxID=35570 {ECO:0000313|EnsemblMetazoa:SCAU003099-PA, ECO:0000313|Proteomes:UP000095300};
RN [1] {ECO:0000313|EnsemblMetazoa:SCAU003099-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:SCAU003099-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_013097252.1; XM_013241798.1.
DR AlphaFoldDB; A0A1I8NY36; -.
DR STRING; 35570.A0A1I8NY36; -.
DR EnsemblMetazoa; SCAU003099-RA; SCAU003099-PA; SCAU003099.
DR GeneID; 106080416; -.
DR KEGG; scac:106080416; -.
DR VEuPathDB; VectorBase:SCAU003099; -.
DR OrthoDB; 5476523at2759; -.
DR Proteomes; UP000095300; Unassembled WGS sequence.
DR GO; GO:0042555; C:MCM complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR CDD; cd17753; MCM2; 1.
DR Gene3D; 2.20.28.10; -; 1.
DR Gene3D; 3.30.1640.10; mini-chromosome maintenance (MCM) complex, chain A, domain 1; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR008045; MCM2.
DR InterPro; IPR018525; MCM_CS.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR027925; MCM_N.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR PANTHER; PTHR11630:SF44; DNA REPLICATION LICENSING FACTOR MCM2; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF12619; MCM2_N; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF14551; MCM_N; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR PRINTS; PR01658; MCMPROTEIN2.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00847; MCM_1; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 458..664
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
FT REGION 1..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..61
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..78
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..148
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 884 AA; 99848 MW; 67D35A40BEF44830 CRC64;
MADLPSSPPP ATPSDAVDRR DLRAAMTSPV GDFEPFENED EILGDQTVRD EEEEDGEELF
GDNMENDYRP MPELDHYDPA MLDDEEDYSE MSQGERLSAE AEMRRRDRAK GIHRDDRDLG
FGQSDDEDDV GPRAKRRAGE KAAAGEMEDA EMVESIENLE DTKGHSTKEW VSMLGPRTEI
ANRFQSFLRT FVDDRGAYTY RDRIRRMCEQ NKSSFVVSYT DLANKEHVLA YFLPEAPFQM
LEIFDKVAKD MVLSIFPTYE RVTTEIHVRI SELPLIEELR TFRKLHLNQL VRTLGVVTAT
TGVLPQLSVI KYDCVKCGYV LGPFVQSQNS EVKPGSCPEC QSTGPFSINM EQTLYRNYQK
ITLQESPGRI PAGRIPRSKD VILLADLCDL CKPGDELEVT GIYTNNYDGS LNTDQGFPVF
ATVIIANHIV VKDCKQVVQS LTDEDIATIQ KLSKDPRIAD RIIASMAPSI YGHDYIKRAL
ALALFGGESK NPGDKHKIRG DINLLICGDP GTAKSQFLKY TEKIAPRAVF TTGQGASAVG
LTAYVRRNPV SKEWTLEAGA LVLADQGVCL IDEFDKMNDQ DRTSIHEAME QQSISISKAG
IVTSLQARCT VIAAANPIGG RYDPSMTFSE NVNLSEPILS RFDVLCVVKD EFDPMQDQHL
AKFVVNSHIK HHPSSDADIE DSQTNSVNEI PQELLRQYIV YSKENIRPKI ANIDEDKIAK
MYSQLRQESF ATGSLPITVR HIESVIRMAE AHARMHLRES VIEADVSMAI RMMLESFIEA
QKFSVMKKMR ATFQKYLAFQ KDHSELLFFI LRQLTLDQLA YIRCKDGPSA THVEIMERDL
IERAKQLDIF NLKPFYESEI FKQNGFAYDA KRRIILQIVQ EAAV
//
