ID A0A1I8NYW6_STOCA Unreviewed; 2038 AA.
AC A0A1I8NYW6;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Dedicator of cytokinesis protein 3 {ECO:0008006|Google:ProtNLM};
GN Name=106088729 {ECO:0000313|EnsemblMetazoa:SCAU003314-PA};
OS Stomoxys calcitrans (Stable fly) (Conops calcitrans).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Stomoxys.
OX NCBI_TaxID=35570 {ECO:0000313|EnsemblMetazoa:SCAU003314-PA, ECO:0000313|Proteomes:UP000095300};
RN [1] {ECO:0000313|EnsemblMetazoa:SCAU003314-PA}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:SCAU003314-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR RefSeq; XP_013109839.1; XM_013254385.1.
DR RefSeq; XP_013109840.1; XM_013254386.1.
DR STRING; 35570.A0A1I8NYW6; -.
DR EnsemblMetazoa; SCAU003314-RA; SCAU003314-PA; SCAU003314.
DR EnsemblMetazoa; SCAU003314-RB; SCAU003314-PB; SCAU003314.
DR GeneID; 106088729; -.
DR KEGG; scac:106088729; -.
DR VEuPathDB; VectorBase:SCAU003314; -.
DR OrthoDB; 8258at2759; -.
DR Proteomes; UP000095300; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd11872; SH3_DOCK_AB; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.1270.350; Dedicator of cytokinesis N-terminal subdomain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR032376; DOCK_N.
DR InterPro; IPR042455; DOCK_N_sub1.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR PANTHER; PTHR45653:SF12; SPONGE, ISOFORM E; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF16172; DOCK_N; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 5..66
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 415..590
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1214..1625
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1707..1796
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1864..2038
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1746..1760
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1770..1796
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1885..1914
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1936..1966
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1967..1992
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1995..2038
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2038 AA; 230862 MW; BE4DF561B4F659DF CRC64;
MWKSSNNKYG VAIHNWNGEV RCGLALDVGD FVEIMEECPK WFRGTCPRKS RAVGIFPKTY
IHIKDLSKID PVVAECTQVL REWSEIWKRL YVKNETYKFT TIGKQMLSIL DNRKELLGAT
LTQDQTLELQ MTVVSKIDWG NRKLGLDLVP RIGPLAVDPH NIGIVGLHNV HVTSAENAKA
SSSRGTLRRK THPNPKILTH HLYFCMREFG YRIGGGDDAE VYFYLYDAIS MKAVSERFVV
KMCKDGFANF YEKVNSNCTV FTDLGAADLN DALYLVAVVM RVGKILPSEK SSSNSCCTGV
SAYRRPFGIG VLSLADIDRY DTTIESEERE YNIKLVYHND EKDFHQLPEL IIKKSSSKFQ
PISTINQSSQ GIVVSLKLLH GGLGQARQEQ PLLFQGSTIT RKMGFPDVIM PGDVRNDMFI
TLEKGEFERG GKNTAKNILV TVVVLDVAGN VLTECLWGAS GMDTQNCYKS MILYHQNAPC
WNEMLRLSVP IDKFSTAHVR FEFRHCSTRE KSEPKLFGFS FARLMDPSGA TLADGHHELY
VYKCEDAGKL MTANYLILPC KPKDPHAKVE CSSIFHRSSK EVFVMRSLLC STKLTQNADL
LSLLQWRAHP EKIQDSLTGV LRLNDEELVK FLQDVLDALF AMFSNEEGNS TQHSGLVFHV
LVSIFSLLQS NKFQHFRPVM NEYIENHFAA ALVYKGLITS VEHMAVFLTK AEHPDPFQKC
FGSLEYIFKL LIQSRKLFAR ATGGQYEDSF RRDLHSLFTA LNGMLAVPSY DVIIPTQEAL
LSSTGVVLEQ LKDTLPAPEL GMLARNMLDA IPRDAPERLV QAKLKAVKDL VSGELFHEDD
SRTVILSVAC KHLRMHLSRR DELRLCAEIL SEILTHLYDL QREQREKVTN TLQHDLDSLC
KNILSILIKT IIIIIEGSNP VLPQLVACLL GLLQLLDETH YKRYWDELSP NKDPRDLKEF
LAKSLLVFEE LVSQDWLVFP PDWLIMKLAC NDVLRCSLEE FAKPLVYRFL GSKSFDSQLW
WSYFSLAVTF LTQPSLQLEK YREPKRRKIL HSHKDMRVLM GFQILSMWSQ LGEQKLHFIP
SMVGPFLEVT LVPEPSLRKA TLTVFYDMMQ CEQAARGSFR LVESELIDKL DLLISENKGD
DEYRELFSTM EHLSLVLLEK VHDENPSWKD AGTAFIASVT RLLERLLDYR SVMQGEENRD
KRMSCTVNLL NFYKNEINRK EMYLRYIYKL HDLHLQAENY TEAGFTLKLY ADMLSWDRES
TSLSPNGNDG QPEWQRKERL YHEILKYFDK GKCWEKGIPL CKELALLYET KRFDYNKLSD
ILIQEAKFFQ NILTQLRPEP EYFRVGFYGL GFPLFVRNKQ FVYRGLEYER ISAFTQRLQT
EFPAAQTLNT NSPPDNSILG ASEQYIQISN VRPVADAQAL KTAMVTVPEK IARFYEVNDV
SRFISDRPIH KGTVDKENEF KSLWIERTTL DIACPLPGIL RWFEVKHKSV QELTPVEFAC
ETMHNVGKDI WDLIQQYRQD PKRNINPFSM RLQGVIDANV MGGISKYQEA FFTEQFLKSP
HGQGQQANVQ RLKALILEKI QILDQALELH GQLAPPGVQP LHKRLLERFS QLKQSLSGLG
RLKRQASESI VNTPLPPLPT EKRSISLGIH NSGANSLMTA NANYYEHDEI YTRPGETLRP
VEAANRFANN SYQTLSKENL SLSSVGGAGD ADLCPPPIPN RPRSQNFGNS ISLDGPEVPP
KRNQTLPSSP GAPPLPPRGI TPDKRASNPM IFNDFSNESS VSSMPRRPHS TSHQHNPKYV
VDISFDDPEA DQQQGPPSLT HSLNCHASVV DSHHLSLAYA PNDFRDSGIS TASAHELNHL
NNLSEESSTN SMSTVHHRDH CRLSSSGSMD NGQFMSASAS NGMSASQREN SASSFDVEDL
PMPAPPIPPK SLNILGSATM HESSSSTSVE GPSSQSLNNT LNHSSSLSHH HHYHTTTPHI
QQQQHHHHHH STQNGHNNDG YVSPKTSTTT NNTTTANTPP VTNKNAIDES HPEVGNTF
//
