ID A0A1I8NZ81_STOCA Unreviewed; 1666 AA.
AC A0A1I8NZ81;
DT 18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT 18-JAN-2017, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS50026};
GN Name=106092799 {ECO:0000313|EnsemblMetazoa:SCAU003403-PB};
OS Stomoxys calcitrans (Stable fly) (Conops calcitrans).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Stomoxys.
OX NCBI_TaxID=35570 {ECO:0000313|EnsemblMetazoa:SCAU003403-PB, ECO:0000313|Proteomes:UP000095300};
RN [1] {ECO:0000313|EnsemblMetazoa:SCAU003403-PB}
RP IDENTIFICATION.
RC STRAIN=USDA {ECO:0000313|EnsemblMetazoa:SCAU003403-PB};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_013115179.1; XM_013259725.1.
DR STRING; 35570.A0A1I8NZ81; -.
DR EnsemblMetazoa; SCAU003403-RB; SCAU003403-PB; SCAU003403.
DR KEGG; scac:106092799; -.
DR VEuPathDB; VectorBase:SCAU003403; -.
DR OrthoDB; 2877710at2759; -.
DR Proteomes; UP000095300; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 8.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 9.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 3.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR PANTHER; PTHR22722:SF14; MEGALIN, ISOFORM A; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF00057; Ldl_recept_a; 7.
DR Pfam; PF00058; Ldl_recept_b; 3.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00179; EGF_CA; 4.
DR SMART; SM00192; LDLa; 9.
DR SMART; SM00135; LY; 10.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR SUPFAM; SSF57424; LDL receptor-like module; 8.
DR SUPFAM; SSF63825; YWTD domain; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS01209; LDLRA_1; 4.
DR PROSITE; PS50068; LDLRA_2; 8.
DR PROSITE; PS51120; LDLRB; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1515..1538
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 71..111
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 155..199
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 243..286
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 287..329
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DISULFID 742..760
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 754..769
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 801..816
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 825..837
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 832..850
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 844..859
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 874..886
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 881..899
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 922..940
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 934..949
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 985..1000
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1024..1039
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1059..1071
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1066..1084
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 1666 AA; 186374 MW; 60513E2A206B13C1 CRC64;
MTCLPLEKAC DGNVDCPDRS DESFRCNQTA NSCKTKTCPP AAMCKMMAQT GAECICPKGF
KHSKRDDLCV DIDECVEQYG VCSQMCVNTP GRYRCLCDEG YRLREDNHTC EAVGEEALLL
YTTQVTVMGV HLRSRRVYTV AKNLTKVIGV AYNGEHIYWT NIQNEAESIV RANPDGSQQE
ILLTSGLDAP EDLAVDWLTG NIYFSDNVMH HIAVCSNDGH YCTVLVTEDV HQPRGVALWP
QRAQIFWSDW GVTPMIARAS MDGTNSKRLV TDKIHWPNGV ALDVHSERIY WVDAKLATIE
SVRSDGTDRR TVLEDILKHP YGLAIFEDKL FWSDWGTKSV HSCNKFTGKD HKIITKDRTI
YALHIYHSAK QPKIPHACER ARCSHLCLLA ENNSYSCACP DGMQLGPNRM RCMRTQKKQR
LFLGVRSNLV QMEHTTFGRH TISSTNALDV FVHELAFNSI NNTVFIADNY QHVIAEFEVK
GEKLTKLVRG NLGNVTALAF DHLAYNLYWS DSERHVIEVF SLQTKQRAIV CFFSGLEAPI
SLAVMPEDGM MFIALKSRRH VHIDQRSLNG QGDHVHVFED ELGDDDIEFA VDYETNTLYW
ADSDLGRISF TDYRNLHAYT FRGRLKRPYS IAIVDEDLFW TELKSNTIHW THKSNMGPLK
RFDLIVNREL YSAVSLPTKI PLLASSPPNV VDHPCQHWNG GCSHICVTLG KFASSCLCPA
GLVFKDASNR TCIEALDCEF RCNTGECLTL SRKCNGRPDC PDASDEANCD PAKGKKPQVI
CAVGEFRCRN GEQCIEGDKR CDGKGQCKDR SDEDHCQNFD KSKFCHRHQH VCDNGNCVDF
SVMCDGTNDC GDNSDEKDCK TIRGKEASTE KMACDKDMFQ CNTGTCLAKS WECDGKIDCI
DGSDEHDKCG IKECPPKTMH KCLLGQCIDR SLVCDGNNDC GDTSDEQNCD MTYGMKRKMT
CGSEKFPMFQ CSSDPNVCLE MSAKCNGSAE CPRGDDEAEC GHICSIYEFQ CKTSKECVRN
EFRCDHEKDC TDGSDEDHCE HHRAWNGTTG TQPSNEKACD PKMFDCGNGR CVDESRVCNG
FEDCENGADE GPLCKTACDP KSGQRMCQNK CRATPSGAVC SCFNGYKLDS DRRTCLDVNE
CEELDPCAQV CENNLGSYRC SCYPEFMMRP DKTSCKSIES EKSLLFSTYD EVRSMTEQPI
MLKVAWKAND SKINGFDVNI RTRKGYFTTD MENILYMVDV DTGIVMAALQ VEMPGKVAVD
WITGNVYVIS RSSQYRIEVC SFTAKMCGAL VKMQPHETLK TLAVDAYNRK LFFVIMEAHA
FGSHKSRIAS TSLDGGGKRE TLLYKDMTYI TTLACDPYKK VLYYTESISK TLQSISYRNG
AERTPTTLIH KGNVVMHPSG LTWYENQVFI VNLGAKEAVH CYLYGSKTCK AFNLNILNAE
DIMVDGISRQ PMNRNPCVMA RCRGMCVLTE FSYECMCGDF IVSESKVCDS TNAISSSVLL
KQQSSDGHEG ATSHVGVFVT LMLLLTAFAI CGLGYFYYRR KGQGRDFIRN LQFQNPLSSI
LPHSRASKTA TMDSGLISSA TGSSTGTTTA SFDVDHDKMY FGSKIQNFLS RTTSNNNTEI
HLETSKPRSV VSEGPSDALL PNILVEDTYD DITQPDDMVG GTRLVP
//
