ID   A0A1I8P2P3_STOCA        Unreviewed;       675 AA.
AC   A0A1I8P2P3;
DT   18-JAN-2017, integrated into UniProtKB/TrEMBL.
DT   18-JAN-2017, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=Peptidoglycan recognition protein family domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   Name=106088838 {ECO:0000313|EnsemblMetazoa:SCAU004266-PB};
OS   Stomoxys calcitrans (Stable fly) (Conops calcitrans).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC   Muscidae; Stomoxys.
OX   NCBI_TaxID=35570 {ECO:0000313|EnsemblMetazoa:SCAU004266-PB, ECO:0000313|Proteomes:UP000095300};
RN   [1] {ECO:0000313|EnsemblMetazoa:SCAU004266-PB}
RP   IDENTIFICATION.
RC   STRAIN=USDA {ECO:0000313|EnsemblMetazoa:SCAU004266-PB};
RG   EnsemblMetazoa;
RL   Submitted (MAY-2020) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
CC       {ECO:0000256|ARBA:ARBA00007553}.
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DR   RefSeq; XP_013109984.1; XM_013254530.1.
DR   AlphaFoldDB; A0A1I8P2P3; -.
DR   STRING; 35570.A0A1I8P2P3; -.
DR   EnsemblMetazoa; SCAU004266-RB; SCAU004266-PB; SCAU004266.
DR   GeneID; 106088838; -.
DR   KEGG; scac:106088838; -.
DR   VEuPathDB; VectorBase:SCAU004266; -.
DR   OrthoDB; 3561023at2759; -.
DR   Proteomes; UP000095300; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008745; F:N-acetylmuramoyl-L-alanine amidase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0009253; P:peptidoglycan catabolic process; IEA:InterPro.
DR   CDD; cd06583; PGRP; 1.
DR   Gene3D; 3.40.80.10; Peptidoglycan recognition protein-like; 1.
DR   InterPro; IPR036505; Amidase/PGRP_sf.
DR   InterPro; IPR002502; Amidase_domain.
DR   InterPro; IPR015510; PGRP.
DR   InterPro; IPR006619; PGRP_domain_met/bac.
DR   PANTHER; PTHR11022:SF66; N-ACETYLMURAMOYL-L-ALANINE AMIDASE; 1.
DR   PANTHER; PTHR11022; PEPTIDOGLYCAN RECOGNITION PROTEIN; 1.
DR   Pfam; PF01510; Amidase_2; 1.
DR   SMART; SM00644; Ami_2; 1.
DR   SMART; SM00701; PGRP; 1.
DR   SUPFAM; SSF55846; N-acetylmuramoyl-L-alanine amidase-like; 1.
PE   3: Inferred from homology;
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        437..457
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          507..650
FT                   /note="Peptidoglycan recognition protein family"
FT                   /evidence="ECO:0000259|SMART:SM00701"
FT   DOMAIN          521..656
FT                   /note="N-acetylmuramoyl-L-alanine amidase"
FT                   /evidence="ECO:0000259|SMART:SM00644"
FT   REGION          1..106
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          120..195
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          215..257
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..86
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        127..144
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        145..181
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        225..257
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   675 AA;  73881 MW;  817A102347056711 CRC64;
     MEKMHLNVHH IQQLQEQTQQ SQQRDSQYDF IQTDDKTSSL SSDESNTEIT ATSHKSDIDN
     FAGSEASCTS STDSGVHGSD NENPATTAPP SPLPRPQPKN ISHSSTKVTV NPLWQHQLHL
     KTKGKPSVSG DNKSKNNNKP KAWSNSDANE REHTGRSCNR PFDNKFAKIE KHLKSGRGDE
     NNSRTPHTSN RNAIEIENVI ANGCAEMMEE QKSALGPRFN DPSRAPSPAP SSIISSSSAD
     TLPNKHPPSH HHCNQSPAMS IRSIDSSIID SDSELDENGE AEGVHKNYVI KKLGTQVSYP
     PKHPDIPVIN RGLTVLNQKI TPNVIGPPPP APLAVLTNLG DSLGLAHSLS QVPIVRPQVA
     ISSSSDVTIG DKHFYEGPVT IQQFLIDNRN KSNEGGGKDN VVFVDDDGVT RTNAKDINST
     PAASDATNVN FLRRKKLIIA GSCAVIALVV VAIIAGIEAS TDNKRKIASG NSEESRKNIP
     INSTIDLISG DVIDDTFEDE VCVKGKLCLI ERDIWRGRPQ GGKMDRQELP LHRVVIAHTA
     SNTCDSLDIC SDRVREIQNY HMDSYKWYDV GYNFLIGGDG RVYVGRGWDD VGAVVRGYNY
     DSVGIAFIGN FDSDKATEAQ LTACLQLLEE GVRLEKLVSN YIVNGALQLS ATRSPGKFLY
     NAIRKWDHWT LETVI
//